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70 Cards in this Set
- Front
- Back
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Hot T-Bone stEAk
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IL-1 (hot)
IL-2 (+T-cell) IL-3 (+Bone marrow) IL4 (+IgE IL-5 (+IgA production) |
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IL secreated by macrophages
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IL 1
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MOst potent Pyrogens
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IL-1 and TNF alpha
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IL secreted By Th cells
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IL 2
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IL-1 causes (4)
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Inflammation
Chemokine for leukocytes Pyrogen Activates Endothelium to express adhesion molecules |
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IL-2 fxn
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+ growth of Th and Tc
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IL 6 fxn
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Stimulates acute-phase reactants and Igs
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Major Chemotactic for neutrophils
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IL-8
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IL that inhibits actions of activated T cells
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IL-10 activates Th2 and inhibits Th1
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Th1 or Th2 non allergic?
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Th1 are the good ones Th2 leaves you Atopic
-Dirty kid is a good lifestile to switch from 2 to 1 * |
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TNF secreted by
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Macrophages
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Macropohages Secrete
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TNF
IL-1 IL-8 |
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Th Cells secrete which interleukins?
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IL-2, 4, 5,
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Mature B cell surface pro
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CD 19, 20, 21(receptor for EBV)
CD40 IgM and IgD MHCII B7 |
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NK cell surface pro
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Recptors for MHC I
CD 16 (binds Fc of IgG) CD 56 |
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All Cells except___ have MHC I
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mature RBC
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Tc surface proteins
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CD3, CD4
TCR CD28 CD40L |
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Th cell Surface pro
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CD4, CD3
TCR |
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Think there is a Tcell problem order what tes?
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CD3 before you get specific
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Compliment paths converge at
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C3
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MAC defficency often leads to what infections
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Nisserial
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Class Pathway activated by
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Antigen antibody complex
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Lectin pathway activated by
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Mannose on microbes
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DAF deficiency leadst to?
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Compliment mediated RBC lysis
Paroxysmal Nocternal Hemoglobinuria |
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DAF and C1 inhibitor fxns
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Keep compliment from activating on self cells
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Lymph node secondary follicles have
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Germinal center
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Lymphnode paracortex houses
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T cells
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Right lymphatic duct drains
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upper right extremity and head
THe thoracic duct drains everthing else |
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Sigmoid colon lymph drains to
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Colic -> Inferior Mesenteric
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Stomach lymph drains to
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Celiac nodes
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Dueodenum/ Jejunum drains to ?
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Superior mesenteric nodes
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Rectum/Anal canal above pectineal line?
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Internal illiac nodes
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Rectom below pectineal line drains to?
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Superficial inguinal nodes
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Testes drains lymph to?
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Super and Deep plexuses --> Para-aortic
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Scrotum Drains lymph to?
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Superficial inguinal nodes
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Splenic Dysfunction leads to susceptibility to?
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Encapsulated organisms
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Common Encapsulated organisms?
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Strep pneumo,
H. influenzae Salmonella N. Meningitidis |
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Postsplenectomy What do you see in Blood?
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-Howell-Jolly bodies
-Target cells -Thrombocytosis |
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Th to Th2
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IL-4
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Th to Th1
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IL-12
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Thymus positive selection occours in what specifc area
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cortex
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Where does negative selectdion in the thymus occur?
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Medulla
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MHC II genes associated with?
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HLA
-DP -DQ -DR |
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MHC I genes associated
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HLA- A, B, C
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How are the Major histocompatability complex genes inherited?
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en-Block
(50% from one parent) |
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HLA- A3 Disease assoc
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Hemochromatosis
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HLA-B27 Disseases assoc.
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PAIR
-Psoriasis -Ankkylosis Spondylosis -IBS -Reiters SYndrome |
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HLA-B8 disease associated
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Graves
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HLA-DR2 disease associated
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-MS
-Hay fever -SLE -Goodpastures |
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HLA-DR3 disease associated
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DM type I
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HLA-DR4 disease associated
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RA
DM type I |
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HLA-DR5 disease associated
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Pernicous Anemia--> B12 deficiency
Hashimotos |
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HLA-DR7 disease associated
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Steroid Responsive Nephrotic Syndrome
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CD4 cells stimulte CD8 via what cytokines?
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IL-2
IFN- gamma |
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CD4 cells activate B-cell via what cytokines?
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IL-4
IL-5 |
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Ig that crosses the placenta
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IgG
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Ig that is huge? (thats what she said)
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M is a huge pentamer
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J-chain associated Ig
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IgA
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Ig mucosal related
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IgA
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Igs on Mature B cell before class switch?
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IgM
IgD |
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Ig Isytypes
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Basically Ig types
IgM, E, A, D, G |
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Ig Idiotype
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Ig epitope determined by specitic antigen binding sites
(VERY SPECIFIC) |
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N terminus is where on Ig
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on the light chain Fb fragment (end of the fork tine)
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C terminal is where?
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at base of the Fc fragment heavy chain
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Granulomatous Diseases
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-TB
-Fungal (histoplasmosis eg.) -Syphillis -Leprosy -Cat scratch -Sarcoid -Crohns -Berylliosis |
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Antibody pumping factories
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Plasma cells (note clock faced nuclei)
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Antinuclear antiboides disease assoc.
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SLE
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Anti-dsDNA, anti SMith
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specific for SLE
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Antihistone
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Drug induced lupus
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Anti-IgG
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RA
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