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6 Cards in this Set
- Front
- Back
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Which cell type mediates transplantation rejection?
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T cells
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What is an alloantigen?
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Self antigen that is different in different individuals
ex: MHC molecules |
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What is an alloreaction?
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An immune response (reaction) to an alloantigen (MHC molecule)
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What are the two different ways that alloantigens can be recognized by the immune system?
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1. Directly - Host T cell recognizes unprocessed allogenic MHC molecules on graft APC
2. Indirectly - Host T cell recognizes processed peptide of allogenic MHC molecule bound to self MHC molecule on HOST APC |
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What are the main antigens that induce acute rejection?
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Major and Minor Histocompatability Complexes
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What are the 3 types of graft rejection?
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1. Hyperactute - preformed antibodies react with vascular endothelium of graft. Activate complement, trigger rapid necrosis
-Ex: Blood Typing mismatch 2. Acute Rejection - CD8+ CTL's react with alloantigens on graft endothelial cells. Results in "endotheliatis" 3. Chronic Rejection - T cells produce cytokines that induce proliferation of endothelial cells/smooth muscles. Causes graft arteriosclerosis. |
