Immunology

Front 1

What HLA subtype is associated with hereditary hemochromatosis?

Back 1

HLA-A3

Front 2

What HLA subtype is associated with the seronegative spondylopathies (i.e. Psoriasis, Ankylosing spondylitis, Inflammatory bowel disease, and Reiter's syndrome = PAIR)?

Back 2

HLA-B27

Front 3

What HLA subtype is associated with Grave's Disease (Autoimmune Primary Hyperthyroidism)?

Back 3

HLA-B8

Front 4

What HLA subtype is associated with Multiple sclerosis, hay fever, SLE, and Goodpasture's syndrome?

Back 4

HLA-DR2

Front 5

What HLA subtype is associated with Diabetes mellitus type I?

Back 5

HLA-DR3

Front 6

What HLA subtype is associated with Rheumatoid arthritis and Diabetes mellitus type I?

Back 6

HLA-DR4

Front 7

What HLA subtype is associated with Pernicious anemia and Hashimoto's Thyroiditis (autoimmune destruction of the thyroid)?

Back 7

HLA-DR5

Front 8

What HLA subtype is associated with steroid-responsive nephrotic syndrome?

Back 8

HLA-DR7

Front 9

Where does positive selection of T-cell receptors occur?

Back 9

Cortex of the Thymus

Front 10

Where does negative selection of T-cell receptors occur?

Back 10

Medulla of the Thymus

Front 11

What receptor of the surface of macrophages is associated with direct stimulation via endotoxin/lipopolysaccharide?

Back 11

CD14

Front 12

Which portion of the antibody is referred to as the antigen-binding fragment?

Back 12

Fab frament (Composed of VL:CL and VH:CH1)

Front 13

What term refers to the process by which an antibody promotes phagocytosis?

Back 13

Opsonization

Front 14

What term refers to the process by which antibody binding prevents bacterial adherence?

Back 14

Neutralization

Front 15

What term refers to the process by which antibody activates complement enhancing opsonization and lysis?

Back 15

Complement activation

Front 16

What type of cell is characterized by CD4, CD3, CD28, and CD40L cell surface markers?

Back 16

Helper T-cell (CD4 positive)

Front 17

What type of cell is characterized by CD8 and CD3 cell surface markers?

Back 17

Cytotoxic T-cell (CD8 positive)

Front 18

What type of cell is characterized by IgM, CD19, CD20, CD21 (receptor for EBV), CD40, MHC II, and B7?

Back 18

B cells

Front 19

What type of cells is characterized by MHC II, B7, CD40, CD14, and receptors for Fc and C3b?

Back 19

Macrophages

Front 20

What type of cell is characterized by receptors for MHC I, CD16 (binds Fc and IgG), and CD56 cell surface markers?

Back 20

Natural Killer Cells (NK cells)

Front 21

What types of cells express MHC I HLA molecules?

Back 21

All nucleated cells (i.e. mature erythrocytes are enucleated and therefore do not possess MHC I molecules)

Front 22

What complement protein is responsible for neutrophil chemotaxis?

Back 22

C5a

Front 23

What complement proteins are considered to be anaphylatoxins?

Back 23

C3a and C5a

Front 24

What complement protein is considered to be one of the primary opsonins?

Back 24

C3b (C3b Binds Bacteria)

Front 25

What complement proteins form the membrane attack complex?

Back 25

C5b-C9

Front 26

Deficiency of what enzyme inhibitor results in hereditary angioedema?

Back 26

C1 esterase deficiency

Front 27

What type of infections is a person who is deficient in C5-C8 at increased risk of developing?

Back 27

Neisseria bacteremia and Neisseria meningiococcemia

Front 28

Deficiency in which GPI-anchored enzyme results in paroxysmal nocturnal hemoglobinuria?

Back 28

Decay-accelerating factor (DAF)

Front 29

What antibodies are specific for SLE?

Back 29

Anti-dsDNA, anti-Smith antibodies

Front 30

What antibody is associated with Drug-induce lupus?

Back 30

Anti-histone antibodies

Front 31

What antibody is associated with Scleroderma (CREST)?

Back 31

Anti-centromere antibody

Front 32

What antibody is associated with Progressive Systemic Sclerosis (Scleroderma)?

Back 32

Anti-Scl-70 (anti-DNA topoisomerase)

Front 33

What antibody is associated primary biliary cirrhosis?

Back 33

Anti-mitochondrial antibody

Front 34

What antibodies are associated with Celiac's disease?

Back 34

Anti-gliadin and anti-endomysial antibodies

Front 35

What antibody is associated with Goodpasture's syndrome?

Back 35

Anti-basement membrane antibody

Front 36

What antibody is associated with Pemphigus vulgaris?

Back 36

Anti-desmoglein

Front 37

What antibody is associated with Hashimoto's thyroiditis?

Back 37

Anti-microsomal and anti-thyroglobulin antibodies

Front 38

What antibody is associated with polymyositis and dermatomyositis?

Back 38

Ant-Jo-1 antibodies

Front 39

What antibodies are associated with Sjogren's syndrome?

Back 39

Anti-SS-A (anti-Ro) and Anti-SS-B (anti-La)

Front 40

What antibody is associated with mixed connective tissue disease?

Back 40

Anti-U1 RNP (ribonucleoprotein)

Front 41

What antibody is associated with autoimmune hepatitis?

Back 41

Anti-smooth muscle antibody

Front 42

What antibody is associated with Type 1 diabetes mellitus?

Back 42

Anti-glutamate decarboxylase antibody

Front 43

What antibody is associated with Wegener's granulomatosis?

Back 43

c-ANCA

Front 44

What antibody is associated with polyarteritis nodosa?

Back 44

p-ANCA

Front 45

What immunodeficiency is characterized by a defect in BTK (a tyrosine kinase gene) that results in inhibition of B-cell maturation?

Back 45

Bruton's agammaglobulinemia (decreased immunoglobulins of all classes)

Front 46

What immunodeficiency is characterized by a defective CD40L on helper T-cells resulting in the inability to class switch?

Back 46

Hyper-IgM syndrome (increased levels of IgM, with decreased levels of IgA, IgG, and IgE)

Front 47

What immunodeficiency results from a defect in B-cell maturation with normal numbers of B-cells and decreased number of plasma cells?

Back 47

Common variable immunodeficiency (CVID)