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9 Cards in this Set
- Front
- Back
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What cell type does tumor immunity primarily rely on?
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T Cells
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What type of T cells do tumors often upregulate to aid in the tumor's survival?
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Treg cells
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What are the 4 types of tumor antigen?
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1. Mutated self protein
2. Product of oncogene or mutated tumor suppressor gene 3. Overexpression or aberrantly expressed self protein 4. Oncogenic virus |
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What are 6 reasons that immune responses to tumors are not always effective?
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1. Tumor may be located in immune priveleged site (ie CNS)
2. Tumors are highly antigenically variable 3. Immune suppression by tumor cell products (fasL, IL-10, TGFbeta) 4. Excessive tumor mass 5. Increased Treg cells (FOXP3 expression) 6. FOX3- can limit Her2/neu oncogene expression |
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What cytokine do Treg cells produce that downregulate CD8+ CTLs?
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TGFbeta
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What are the two categories of immune therapies?
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1. Passive immunotherapy: uses the products of immune cells, or ex-vivo engineered immune cells to treat disease
- ex: monoclonal antibody therapy 2. Active Immunotherapy: stimulates patients own immune system to respond to disease |
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What are the 3 types of passive immunotherapy?
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1. Monoclonal antibody therapy - using engineered antibodies
2. Interleukins - IL-2, interferons, IL-12. Activate entire immune system 3. Cell Transfer - Autologous T cells which have been expanded in vitro and modified by molecular engineering |
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What is the main type of active immunotherapy?
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Vaccines
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What are 2 proteins that have been target in breast cancer using monoclonal antibody therapy?
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Her2/neu proteins - disrupts cell signaling
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