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31 Cards in this Set
- Front
- Back
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p(perfect HLA match) for 2 unrelated people
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10^-5
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p(perfect HLA match) for 2 people from same ethnic group
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1/30000
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animal->human transplant is called
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xenogeneic
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human->unrelated human transplant is called
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allogeneic
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human->identical twin transplant is called
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syngeneic
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human->self transplant is called
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autochthonous
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___ (3) are weakly immunogenic and don't require HLA match
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liver
cornea bone |
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___ (2) are highly immunogenic
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bone marrow
skin |
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immunogenicity is determined by ___.
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level of MHC II expression
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a single MHC II mismatch with perfect MHC I match is worse than perfect MHC II match with ___ MHC I mismatches
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4
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allogeneic MHC causes immune reaction by ___ (2)
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mimicking presence of foreign Ag on its own
mimicking presence of foreign Ag together with self Ag |
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mismatch in MHC I alone causes proliferation of
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CD8 cells
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mismatch in MHC II alone causes proliferation of
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CD4 cells
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mismatch in both MHC I and II causes proliferation of
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CD4
CD8 B cells |
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B cell activation in graft rejection causes ___ with release of ___
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total activation of complement
inflammatory mediators |
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2 parts of rejection response
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inflammation
thrombosis |
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DCs have lower ___ than macrophage, but higher ___. therefore it's very important to ___ them during transplant.
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phagocytic capacity
MHC expression wash them out |
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direct alloantigen presentation is ___. indirect alloantigen presentation is ___.
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where T cell binds foreign MHC when it's on its donor APC
where T cell binds degraded piece of foreign MHC after donor APC has been eaten by native APC |
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T/F: direct alloantigen presentation is more effective than indirect in stimulating T cell proliferation
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false: indirect is more effective
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hyperacute reaction occurs in ___ (time) and is caused by ___
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minutes/hours
pre-existing Abs/complement |
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accelerated reaction occurs in ___ (time) and is caused by ___
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days
reactivation of memory T cells |
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acute response occurs in ___ (time) and is caused by ___
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days/weeks
primary activation of T cells |
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chronic rejection is characterized by
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intimal thickening
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mycophenolate mofetil action
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inhibition of lymphocyte guanine nucleotide synthesis
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steroid has both ___ and ___ effects
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antiinflammatory
immunosuppressive |
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steroids inhibit T cell signalling by (2)
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upregulating IkB
binding p65 |
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methotrexate action
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folate antagonist->inhibits nucleotide synthesis
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azathioprine inhibits ___, especially in ___, by ___ing
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cell division
CD8 cells causing synthesis of non-physiological nucleotides |
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rapamycin action
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blocks IL-2 signalling by binding TOR, downstream of IL2-R
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2 mAbs used as immunosuppressants
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anti CD3
anti CD25 |
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steroid side effects (8)
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salt retention
hypertension DM peptic ulcer bone changes catabolic state dyslipidemia cataracts |
