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16 Cards in this Set
- Front
- Back
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What is the function of the innate immune system?
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The innate immune system prepares the adaptive system to respond. Innate immunity provides first line of defense.
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What are the cell types seen in innate immunity?
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Dendritic Cells, Macrophages (Monocytes), NK Cells, Complement, Neutrophils, Eosinophils, etc
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When stimulated, what molecule do dendritic cells and macrophages express that stimulate T Cells
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B7
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What is a major cell type that traffic to the sites of wounds?
What are they attracted by, what do they do? |
- Neutrophils
- Provide RAPID response - attracted by complement C5a - Phagocytose foreign cells, toxins, and viruses |
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What type of molecule do macrophages and NK cells produce that stimulate the immune response?
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Cytokines
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Besides, neutrophils, what other type of (more specialized) cell type migrates to a wound?
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- Monocytes which give rise to tissue macrophages
- While neutrophils provide rapid response, macrophages persist and provide PERSISTENT RESPONSE |
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What cell type captures antigen in the periphery and transports it to the lymphnodes?
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Dendritic Cells
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What are 4 examples of receptors that phagocytes have which allow them to ingest pathogens?
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1. Mannose Receptor
2. Mac-1 intergrin (allows binding of microbes opsonized w/ complement) 3. Scavenger Receptor 4. Toll like receptor |
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Once phagocytosed, how are microbes destroyed inside a phagocyte?
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By joining vacuole with microbe in it to a lysosome with ROS (reactive oxygen species)
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What molecule do NK cells produce that stimulate macrophages?
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IFN-Gamma
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How do NK cells destroy a microbe?
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- Binds microbes opsonized with IgG (to NK FcGamma receptor)
- releases perforin to kill |
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What molecule do macrohpages release that stimulates NK Cells?
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IL-12
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Why do NK cells not kill self cells?
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Because binding of normal MCH-I molecule on self cells INHIBITS the activity of NK Cells
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Can innate immune cells change their receptors to better see pathogens?
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No, they contain static/pre-determined receptors that encode for stereotypical pathogen antigens
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What do Toll-like Receptors (TLRs) bind to?
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Pathogen-Associated Molecular Patterns (PAMPs)
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What is the receptor on a T-Cell which binds to the B7 produced by dendritic cells and macrophages?
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CD28
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