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16 Cards in this Set
- Front
- Back
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What does a primary response lead to |
Alteration in subsequent responses |
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Innate cells VS b/t cells responses |
Innate Immediate response No recall response
B/t cells Slow initial Recall response - much faster following re challenge |
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Repeated exposure to antigen changes B cell memory response by |
Increasing in Ab levels and affinity |
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Explain the development of memory B cells |
B cells precursor rearranges it’s immunoglobulin genes
Immature B cell bound to self cell surface antigen is removed from the repertoire
Mature B cell bound to foreign is activated
Activated B cells give rise to plasma cells and memory cells |
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Development of memory B cells #2 |
Generation of B cell receptors in the bone marrow
Negative selection in the bone marrow
Migration of B cells to peripheral lymphoid organs and activation
Antibody secretion and memory cells in bone marrow and lymphoid tissue |
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Activated B cells give rise to what cells |
Plasma cells and memory cells |
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How to identify cell populations |
Microscopy - can be specific and non quantitative
Flow cytometry - specific and quantitative |
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Name the markers of memory B cells |
CD19+ and CD27+ |
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Cd19 and cd27 IgD- does what |
Switched memory cells (igG secreting) |
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Cd19 cd27 igD does what |
UNswitched memory cells (IgM secreting) |
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Cd27 is required for what |
Activation info plasma cellls - ab secretion and is also part of the TBF receptor family - ligand = CD70 |
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Name the development of memory T cells |
Back (Definition) |
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B and T cells memory responses |
B cells - Each activation increases affinity and continue to mutate V regions
T cells - affinity of original Ag activation does not alter And v regions are not further changed in memory cells |
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Memory cells prevent what |
Activation of naive B or T cells to the antigen which originally resulted in the development of memory cells |
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Name detrimental actions from B cells |
Chronic diseases due to LTM
Loss of cells in the SLE
Ie allergy, multiple sclerosis |
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Name types of vaccinations use for clinical induction of memory |
Small pox with cow extract (T cell vaccine) Helps B cells - Ab production
TB (T cell vaccine) helps for Macrophages (IFN gamma production)
Various viruses including flu etc neutralising Abs + CD8 + killing of infected cells |
