Immunohematology: Chapter Twenty Two

Front 1

Relationship testing refers to the testing of ____________________ that are inherited to determine the presence or absence of a biological relationship

Back 1

genetic markers

Front 2

The _________ complex represents the most polymorphic genetic system in the human genome

Back 2

HLA

Front 3

Only antigens expressed by the ___ or ____ loci are considered for relationship testing with non-DNA based typing

Back 3

A or B

Front 4

_________ refers to polymorphisms of the DNA that can be detected by restriction enzymes; relate to the presence of ________.

Back 4

RFLP; VNTR

Front 5

STRs have repeats that are _________ bp long

Back 5

4-5

Front 6

STR present on the ____ chromosome can verify only male lineage

Back 6

Y

Front 7

______________ can only verify maternal lineage

Back 7

mitochondrial DNA

Front 8

The term ________ is used when the bands between the child and the AF do not match

Back 8

mismatch

Front 9

a minumum of ____ mismatches is required before an opinion of nonpaternity is rendered

Back 9

2

Front 10

A _____________________ occurs when a marker is detected in the child and is absent in the mother and the AF or when the AF's phenotype demonstrates two markers and the child has neither of them

Back 10

direct exclusion

Front 11

An ___________________ occurs when a single marker is detected in the child and a different single marker is detected in the alleged father

Back 11

indirect exclusion

Front 12

False indirect exclusions occur secondary to the presence of ________ alleles

Back 12

silent

Front 13

In which genetic system is the allele frequency distribution continuous?

Back 13

DNA polymorphisms by RFLP

Front 14

A false direct exclusion in RBC antigen genetic systems can be caused by

Back 14

a lack of precursor substance

Front 15

Which organization offers an accreditation program for parentage testing labs?

Back 15

AABB

Front 16

A newborn is typed as Group O. her mother is Group A. Determine the maximum number of theoretical blood types that the father could be to produce a child of this ABO type.

Back 16

A, B, O

Front 17

Which offspring scenerio could NOT be the result the marriage shown:

Father: MM/Mother: NN—Child: MN

Father: MN/Mother: NN—Child: NN

Father: MN/Mother: MM—Child: NN

Father: NN/Mother: NN—Child: NN

Back 17

Father: MN/Mother: MM—Child: NN

Front 18

Which of the following is astructure located within the cell nucleus that carries genes in a linear orderas a part of the DNA molecule?

Back 18

chromosome

Front 19

The inclusionarycalculations are deemed invalid if which of the following possible subjects isto be ruled out as the alleged father of the child?

Back 19

Father

Front 20

Apparent oppositehomozygosity is also known as

Back 20

direct exclusion.

Front 21

CODIS stands for

Back 21

Combined Offender DNA IndexSystem

Front 22

What test systems are usedin the ascertainment of paternity

Back 22

RBC, HLA, enzymes, serumproteins

Front 23

How is DNA testingadvantageous to paternity cases

Back 23

It provides visual insight into genetically inherited differences among individuals.

Front 24

What technology is used todemonstrate the presence of allelic variants of red blood cell enzymes andserum proteins

Back 24

Electrophoresis

Front 25

Which of the following AABBstandards must be met in paternity testing

Back 25

DNA testing usingdouble-locus probes

Front 26

Given the gene frequenciesof MS and NS, what is the genotype frequency (MS/NS), assuming the genotypecould occur in two different ways: MS: 0.2578 or NS: 0.0628

Back 26

0.0324

Front 27

What component of theHardy-Weinberg equation (p2 + 2pq + q2) signifiesheterozygotes

Back 27

2pq

Front 28

A child was found toexpress the M+N+ phenotype. The mother's phenotype was M+N-, as was thefather's. What type of exclusion is evident in this case?

Back 28

Direct

Front 29

How is HLA serologictesting performedwas

Back 29

B lymphocytes are harvestedand introduced to a panel of test sera specific for antigens of the HLA system.

Front 30

In paternity testing, whichof the following systems is the first to be tested against samples drawn fromthe mother, alleged father, and child?

Back 30

ABO

Front 31

How many chromosomes doesthe developing child normally carry

Back 31

46

Front 32

Samples for paternitytesting have arrived at Forensic Laboratories, Inc. What documentation shouldthe shipping container contain?

Back 32

Department code

Front 33

In HLA serologic testing, howare cytotoxic effects of antigen-antibody interactions detected?

Back 33

The cells remain clear.

Front 34

What is the statisticalbasis of the Hardy-Weinberg principle?

Back 34

Selection of mates is independentof blood types and therefore is random.

Front 35

What is the basic unit ofinheritance that determines the production or nonproduction of specific markers

Back 35

gene

Front 36

What is the majorconstituent of chromosomes

Back 36

DNA

Front 37

Calculate the relativegenotype frequency of MS/Ns, given that the genotype frequencies of MS/Ns andMS/Nu are 0.1999 and 0.0002, respectively. Gene frequency: MS, 0.2578; Ns,0.3877; Nu, 0.0004.

Back 37

0.999