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10 Cards in this Set

  • Front
  • Back
Root causes of Transfusion Fatalities
-Failure to follow SOPS
-Preprinted sample labels
-pt. w/ similar or identical names
-Sequential patient identifiers
-Verbal and stat orders
Rh Blood Group System
Currently
5 common antigens
(53 overall)
Antigens all proteins
Many nomenclatures
Fisher-Race: DCE Terminology
Presents the easiest way to to communicate the research and serologic findings
5 major antigens
D (RH+)
C/c
E/e
Genes of CcEe loci act as antithetical pairs
Rh genes are co-dominant
No little d (amorph)
Weiner
Uses different names for 5 basic antigens
Antigens are
Rho= D
rh’ = C
rh’’ = E
hr’ = c
hr’’ = e
Abs can recognize single or multiple factors
Example: R’ gene produces antigens that react with antibodies rh’, Rho, and hr’’
Fisher-Race and Weiner Nomenclature
R r
R r
R r
R r
The Big Four
The Big Four
Only four are common enough to memorize (97% are R1, R2, R0 or r)
R0 is most common in blacks, least common in whites
r is always second in frequency
R1 always comes before R2
Rh Blood Group System
Polypeptide antigens embedded in RBC membrane
Not expressed on other tissues
ABO antigens ubiquitous
Well developed at birth
Good immunogens
ESP “D”
Inheritance
RH complex on chromosome 1 codes for:
RHD
Codes for D protein
RHCE
Codes for C, c, E, e
RHAG gene on Chromosome 6
Necessary for expression of RH antigens
Important for ammonium transport
Each Parent contributes one set of genes
Inheritance
C= serine @ position 103
C = proline @ position 103
E= proline @ position 226
e= alanine @ position 226
Rho (D) antigen
A very potent antigen (80% may form antibody with exposure)
Only antigen where we give antigen-matched blood without a corresponding AB
85% positive - Rh positive
15% negative - Rh negative

Comment: Rh- blood makes up ~1/3 of our blood inventory because ARC preferentially recruits Rh- donors
A very potent antigen (80% may form antibody with exposure)
Only antigen where we give antigen-matched blood without a corresponding AB
85% positive - Rh positive
15% negative - Rh negative