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41 Cards in this Set
- Front
- Back
adhesion molecules
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surface molecules that bind counter molecules on other cells, causing close contact btn cells
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afferent lymphatics
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lymphatic vessels that enter the lymph node
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α-β TCR
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refers to the T cell antigen heterodimer receptor on more than 90% of T cells
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alternative splicing
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process by which mRNA is spliced to create either a mu or delta heavy chain constant region
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anergy
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process by which a stimulus causes cells to become non-responsive
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apoptosis
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self-induced cell suicide
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autoreactive
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refers t immunological responses against self antigens
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BCR
mIg |
antigen-specific receptor on B cells tightly associated with CD79a/b
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CD19
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molecule present on all B cells (panmarker)
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CD3
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molecule present on all T cells (panmarker)
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CD79a/b
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complex expressed on cell surface with BCR
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combinatorial diversity
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refers to the multitude of gene segments that comprise variable regions of BCR and TCR
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death by neglect
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phenomenon by which developing thymocytes die because they do not receive proper signals
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D
diversity |
gene segment that encodes part of the Ig heavy chain or TCR β chain
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down regulation
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process by which expression of cell surface molecules are decreased
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efferent lymphatics
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lymphatic vessels that leave tissues
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γ-δ TCR
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T cell antigen heterodimeric receptor on about 10% of T cells
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germline DNA
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genomic DNA that has not been altered by recombination events
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glycocalyx
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filamentous layer on the surface of specialized endothelial cells
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HEV
high endothelial venules |
specialized post-capillary venules that serve as sites for lymphocytes to exit blood and enter lymph node parenchyma
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integrin
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adhesion molecules that induce firm contact btn cells that have appropriate counter molecules
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J
joining |
DNA segment that encodes for a segment of light and heavy chain variable regions, as well as α-β TCR
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junctional diversity
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heterogeneity that results from either removal or addition of bases at the junction of DNA segments V, D, J
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kappa
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one of two light chain constant regions
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L selectin
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molecule whose interxn with counter molecules causes lymphocytes to roll on the endothelium
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lambda
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one of two light chain constant regions
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lineage commitment
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process by which double positive thymocytes become CD8+ or CD4+ exclusive
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matrix metalloproteinases
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enzymes that cause the degradation of endothelial cell wall to allow cells to pass from blood vessels to tissues
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negative selection
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destruction of developing thymocytes as a result of strong signals when they interact with thymic epithelium
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panmarker
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refers to a cell surface molecule present on a particular cell type and not present on other cells
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positive selection
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proliferation of developing thymocytes when they receive appropriate signals
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preBCR
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precursor complex expressed on developing B cells prior to expression of the BCR complex
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pre-Tα
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chain that associates with β TCR to form precursor complex on developing T cells in the thymus
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psuedo-light chain
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chain that associates with the heavy chain to form a precursor complex on developing B cells
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RAG-1, RAG-2
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recombination activating genes encode proteins required for somatic recombination of variable region of B or T cell antigen receptors
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somatic recombination
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process by which DNA segments are rearranged to form a variable region for either the B or T cell receptor
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TCR
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T cell receptor that recognizes antigen-MHC complexes
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tdt
terminal deoxynucleoidyl transferase |
enzyme that catalyzes the template-independent insertion of nucleotides btn variable region segments
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tolerance induction
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process by which the immune system remains non-responsive to self antigens
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triggering threshold
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level of signal intensity beyond which cells are destroyed via negative selection
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V
variable |
region present in each chain of B and T cell antigen recognizing receptors
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