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32 Cards in this Set
- Front
- Back
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1. Know the machinery of the immune system: Tissues, cells and blood proteins (e.g., complement) of the Immune System (IS) -know who are phagogcytes, APCs, killer cells (both CD8 and NK cells), helper cells (Th1 and Th2)
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2. How do we classify the immune system? Innate and Adaptive Immunity a. -know cells and characteristics of each (e.g. processes involving T or B cells or antibodies or cytokines secreted by T or B cells are part of the adaptive IS)
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3. Know receptors for antigen (BCRs and TCRs) a. -identical on a single cell, different on different cells b. -know the structure of the antigen bound by the TCR and bound by the BCR
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4. How does inflammation occur? What are the processes that occur during and at the end of inflammation. Why is inflammation good but sometimes can be bad?
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5. Understand the concept of clonal amplification
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6. Know the hematopoietic system – how we can stimulate it in some cases such as neulasta
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7. Know the basic anatomy of secondary lymphoid tissue (e.g. lymph node – Tcell area, follicle, germinal center, lymphatic vessels etc)
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8. How do antibodies function?
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9. What are the basic principles of adaptive immunity – Diversity, specificity, memory and self-tolerance. How are these achieved?
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10. Basis of vaccination: understand why a secondary response (memory response) is faster and specific to one antigen
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11. What happens when the immune system is malfunctioning? For example, understand the difference between autoimmune disease and immunodeficient disease. Know examples of malfunctioning immune system (IDDM, allergies, SCID, organ rejections, GHD)
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12. Basis of vaccination: understand why a secondary response (memory response) is faster and specific to one antigen
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13. What is the hygiene hypothesis?
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1. Structure of Igs (Abs), V and C regions, complementarity determining regions (CDRs), isotypes, immunoglobulin domain
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2. How do antibodies recognize antigens? How can antibody-antigen binding be problematic?
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3. What is the difference between Polyclonal vs Monoclonal antibodies
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4. How are antibodies used in diagnostic tests? How is the principle of passive immunity used in commercial applications?
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5. Generation of diversity in the immune system(when, who, where and how) - you need to know the function of all proteins/complexes mentioned in the slides
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6. Ig gene rearrangement – Somatic Recombination mechanism
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7. Understand the principle of single antigen specificity
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8. Ig diversity BEFORE antigen encounter: 1) random combination of V and J (light chain) and V, D, J (heavy chain) gene segments; 2) junctional diversity; 3) combinatorial association of heavy and light chains
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9. Ig diversity AFTER antigen encounter: somatic hypermutation followed by affinity maturation
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10. Isotype switching and function of individual Ig (Ab) isotypes
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11. Figure 2-29 you need to know the main functions of antibodies i.e. where you see ++ or +++
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1. TCR: structure - What are the components that make up a TCR and TCR complex
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2. TCR: How is diversity generated?
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3. What are the differences between B and T cells in development and in making their respective receptors?
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4. What is SCID? What are the consequences of genetic defects in specific parts of the immune system?
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5. How do T cells recognize antigens?
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6. What are the roles of different T cell types?
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7. What is antigen presentation? What cell types can present antigens and what structures are involved in antigen presentation?
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8. What are the differences between MHC I and MHC II? How do they relate to intracellular versus extracellular pathogens?
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