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28 Cards in this Set
- Front
- Back
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Histamine
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Vasoactive factor
Source= Mast cells, basophils, platelets Dilates microvasculature |
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Serotonin
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Vasoactive factor
Source= Mast cells, platelets Vasoconstriciton and increases blood pressure |
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Kinins
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Vasoactive factor
Source= Serum kinninogens Vasodilation, increase permeability |
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Leukotrienes
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LTB4, C4, D4, E4
Vasoactive factors Source = arachadonic acid Increase permeability |
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Prostaglandins
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Thromboxane, PGF2, Prostacyclin, PGE2
Vasoactive factor Source= Arachadonic acid Vasoconstriction, vasodilation |
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Vasoactive factors
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Histamine, serotonin, kinins, leukotrienes, prostaglandins
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RANTES
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CC Chemokine
Chemotactic factor Signals monocyte migration Source = many cells |
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MCP-1
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CC Chemokine
Chemotactic factor Signals monocyte migration Source = many cells |
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IL8
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CXC Chemokine (chemotactic factor)
Signals neutrophil migration and activation Source = many cells |
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C5a and C567
what, source, responding cell |
Chemotactic factors
Source = complement Cell response = neutrophils, monocytes |
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Kallikrein
what, source, responding cell |
Chemotactic factor
Source = serum and tissue Cell response = neutrophils |
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LTB4
what, source, responding cell |
Chemotactic factor
Arachidonic acid Cell response = neutrophils |
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Chemotactic factors
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Chemokines, C5a, C567, Kallikrein, LTB4
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Adhesion molecules
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Selectins, integrins, Ig superfamily, vascular adressins
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Selectins
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Adhesion molecule
On epithelial cells Binds glycoprotein on LEUKOCYTES Mediates MARGINATION P selectin E selectin |
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P selectin
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Adhesion molecule
On epithelial cell Induced by histamine, LTB4, C5a expressed within minutes |
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E selectin
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Adhesion molecule
On epithelial cell Induced by TNF and LPS Expressed 4 to 12 hrs after exposure |
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Integrins
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Heterodimers,
Expresses constituively on leukocytes Binding weak until activated by cytokines, chemokins Mediates pavementing and emigration LFA-1 MAC-1 VLA4 |
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LFA-1
(CD11a/CD18) |
Integrin adhesion molecule
expressed on PMNs, MPs, leukocytes |
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Mac-1
(CD11b/CD18) |
Integrin adhesion molecule
= CR3 expressed on PMNs, MPs |
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VLA4
(CD49a/CD29) |
Integrin adhesion factor
Expressed on MPs, lymphocytes |
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Ig Superfamily
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Adhesion molecules
ICAM-1 = CD54 VCAM = CD 106 |
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ICAM-1
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Ig superfamily adhesion factor
expressed on epithelial cells only during inflammation Induced by TNFa, IL1, IL6 Appears 4 hours after stimulation, peaks at 24 hours Binds CD11a/CD18 and CD11b/CD18 Required for PMN emigration |
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VCAM
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Ig superfamily adhesion factor
= CD106 Mediates MP and lymph adhesion and emigration |
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Inflammatory Cytokines
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TNF a, IL-1, IL-6
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TNFa
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Inflammatory cytokine
Produced by MPs and T cells early in development Induces IL1 and IL6 production Increases adhesion molecule expression Weak pyrogen Strong cahectin Induces acute phase proteins High levels are toxic |
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IL-1
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Inflammatory cytokine
Produced by various, especially MPs when killing Induces production of IL6, IL 8, TNFa Increases adhesion molecule expression Strong pyrogen Weak cachectin Tissue repair= stimulates collagenase production, fibroblast proliferation Induces acute phase proteins |
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IL-6
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Inflammatory cytokine
Produced by MP, endothelial cells, fibroblasts Produced in response to IL1 and TNFa Induces acute phase proteins |
