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37 Cards in this Set

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adhesion molecules
molecules whose interactions wtih counter molecules results in close cell-cell contact
anaphylatoxins
C3a, C4a, C5a bind to cognate receptors on mast cells and basopils
bradykinin
peptide released from kininogen, causing increase in vascular permeability
C5a
anaphylaxin
CD18
β2 integrin chain
chemokines
molecules that attract cells with the appropriate receptors
cytokines
molecules that are secreted by leukocytes, some cause stimulation others inhibition
diapedesis
the movement or passage of blood cells, esp WBCs, through intact capillary walla into surrounding body tissue
edema
an excessive accumulation of fluid in tissue spaces
E-selectin
adhesive molecule expressed on the endothelium in response to IL-1 and TNF
extravasation
the movement of cells from a vessel into surrounding tissues
FcεR
receptor for the Fc portion of IgE
histamine
molecule released from mast cells and basophile, increases vascular permeability
ICAM-1 and ICAM-2
counter molecules for the adhesive molecule LFA-1
integrins
molecules that induce firm cell-cell adhesion when they bind counter molecules
interferon gamma (IFN-γ)
type 1 cytokine secreted primarily by CD4+ Th cells, some secreted by IL-12 activated NK cells
interleukin-1 (IL-1)
cytokine secreted by activated macrophages
interleukin-10 (IL-10)
type 2 cytokine, secreted by CD4+ Th2 cells, inhibits IL-12 secretion by dendritic cells and macrophages
interleukin-4 (IL-4)
type 2 cytokine, secreted by mast cells and CD4+ Th cells, required for Th0 to Th2 and for isotype switch to IgE
interleukin-6 (IL-6)
inflammatory cytokine secreted by activated macrophages, triggers CRP secretion by hepatocytes
interleukin-8 (IL-8)
chemokine secreted by activated endothelial cells, attracts neutrophils to site
kallikrein
source- intrinsic coagulation pathway - link to complement, bradykinin release and neutrophil activation
leukocyte adhesion deficiency (LAD)
genetic disorder- caused by deficiency of CD18 which is the common chain for LFA-1 and Mac-1
leukocytes
white colorless cells in th blood (neutrophils, monocytes etc)
LFA-1
adhesion molecule-heterodimer-one chain is CD18 which is the β2 integrin chain
L-selectin
adhesive molecule on the naive lymphocytes that induces rolling on the HEV (not on memory cells)
Mac-1
integrin-heterodimer-one chain is CD18-the β2 integrin chain, on monocytes and macrophages
matrix metalloproteinases
enzymes that degrade basement membrane (localized region) allow cells to leave the blood and enter tissues
monocyte chemotactic protein (MCP-1)
chemokine that atracts primarily monocytes, but also attracts lymphocytes
P-selectin
adhesive molecule, present in endothelial cell cytosol, histamine induces translocation to the cell surface
Rantes (Skip)
chemokine, attracts primarily memory T cells to the site, but also attracts monocytes
selectins
adhesive molecules(L-selectin on naive lympocytes, P-selectin and E-selectin on endothelial cells)
stable conjugate
refers to cell-cell interaction
systemic inflammatory response syndrome (SIRS)
an inflammatory condition arising because neutrophils do not undergo apoptosis after infection is resolved
transforming growth factor beta (TGF-β)
inhibitory cytokine, inhibits proliferation of T cells and B cells, produced predominantly by Th2 cells
tumor necrosis factor (TNF)
cytokine produced by activated macrophages and CD4+ Th1 cells (pg122 text)
β2 integrin
CD18, one chian of the heterodimeric molecules LFA-1 and Mac-1