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44 Cards in this Set
- Front
- Back
anergic
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non responsiveness
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apoptosis
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cell suicide
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B7
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counter molecule for CD28 (and CTLA-4)
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caspase (skip)
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protease (originally refered to as ICE protease and ICE like protease) cleave following aspartate residue
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CD2
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panmarker on T cells (also present on NK cells)
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CD28
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costimulatory molecule for T cell activation (ligand is B7)
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CD3
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proteins expresed as a complex with the T cell receptor
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CD4
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lineage defining molecule (T helper cells)
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CD4+ T cells
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T cells whose function is to secrete cytokine
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CD40L
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ligand for CD40 required for B cell (CD40-CD40L) isotype switching and memory cell formation
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CD45
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tyrosine phosphatase
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CD8
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lineage defining molecule (cytotoxic T cells)
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CD95-CD95 ligand
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proteins whose interaction leads to apoptosis
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class I MHC
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molecules that display peptides - complexes recognized by CD8+ T cells
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class I MHC restriction
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refers to the fact that CD8+ T cells only recognise antigenic peptides displayed in the groove of class I MHC proteins
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class II MHC
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molecules that display peptides, complex is recognized by CD4+ T cells
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class II MHC restriction
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refers to the fact that CD4+ T cells only recognize antigenic peptides displayed in the groove of class II MHC proteins
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conjugate formation
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interaction of two cells
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costimulatory molecules
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proteins whose interactions with counter molecules is either required for, or enhances cell activation
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dendritic cell
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a professional APC in the skin
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FADD (Skip)
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Fas associated death domain
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Fas (skip)
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a protein (CD95) that binds to the fas receptor (CD95L) induces apoptosis of the cell
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ICE-like protease (skip)
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interleukin-1 beta converting enzyme (now referred to as caspases)
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interferon-gamma
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cytokine, type 1, crucial for optimal cytotoxic function of macrophages
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interleukin-10
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type 2 cytokine, down regulates dendritic cell or macrophage secretion of IL-12
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interleukin-12
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cytokine released by APC
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interleukin-13 (skip)
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type 2 cytokine
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interleukin-2
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type 1 cytokine and growth factor for T cells
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interleukin-4
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type 2 cytokine, may also be secreted by mast cells, role in isotype switching to IgE
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memory T cell
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T cells that play a role in immunosurveillance (these cells have been previously activated)
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Fas receptor (skip)
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CD95 ligand (CD95-CD95L interaction leads to apoptosis)
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NK cells
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innate immune cytotoxic cell, primary role destruction of virally infected cells
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osmotic lysis
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altered ion flux leads ultimately to net flux of water in the cell and then cell rupture
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perforin
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a protein present in granules of NK cells and CD8+ cytotoxic cells (cause cell lysis)
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raf kinase
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initial kinase in a kinase cascade following activation of ras
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Th0 cells
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intermediate cell in the activation of Thp to either a Th1 or a Th2 cell
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Th1 cells
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CD4+ T cells that secrete Type 1 cytokines
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Th2 cells
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CD4+ T cells that secrete Type 2 cytokines
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Thp cells
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naive cells that have not yet been activated (T helper precursor)
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TRADD (skip)
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tumor necrosis factor receptor associated death domain
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transforming growth factor beta
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inhibitory cytokine
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Type 1 cytokines
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primarily required for cellular immunity
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Type 2 cytokines
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primarily required for humoral immunity
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Zap 70 kinase
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tyrpsine kinase that is activated when T cells are activated
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