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44 Cards in this Set

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  • Back
anergic
non responsiveness
apoptosis
cell suicide
B7
counter molecule for CD28 (and CTLA-4)
caspase (skip)
protease (originally refered to as ICE protease and ICE like protease) cleave following aspartate residue
CD2
panmarker on T cells (also present on NK cells)
CD28
costimulatory molecule for T cell activation (ligand is B7)
CD3
proteins expresed as a complex with the T cell receptor
CD4
lineage defining molecule (T helper cells)
CD4+ T cells
T cells whose function is to secrete cytokine
CD40L
ligand for CD40 required for B cell (CD40-CD40L) isotype switching and memory cell formation
CD45
tyrosine phosphatase
CD8
lineage defining molecule (cytotoxic T cells)
CD95-CD95 ligand
proteins whose interaction leads to apoptosis
class I MHC
molecules that display peptides - complexes recognized by CD8+ T cells
class I MHC restriction
refers to the fact that CD8+ T cells only recognise antigenic peptides displayed in the groove of class I MHC proteins
class II MHC
molecules that display peptides, complex is recognized by CD4+ T cells
class II MHC restriction
refers to the fact that CD4+ T cells only recognize antigenic peptides displayed in the groove of class II MHC proteins
conjugate formation
interaction of two cells
costimulatory molecules
proteins whose interactions with counter molecules is either required for, or enhances cell activation
dendritic cell
a professional APC in the skin
FADD (Skip)
Fas associated death domain
Fas (skip)
a protein (CD95) that binds to the fas receptor (CD95L) induces apoptosis of the cell
ICE-like protease (skip)
interleukin-1 beta converting enzyme (now referred to as caspases)
interferon-gamma
cytokine, type 1, crucial for optimal cytotoxic function of macrophages
interleukin-10
type 2 cytokine, down regulates dendritic cell or macrophage secretion of IL-12
interleukin-12
cytokine released by APC
interleukin-13 (skip)
type 2 cytokine
interleukin-2
type 1 cytokine and growth factor for T cells
interleukin-4
type 2 cytokine, may also be secreted by mast cells, role in isotype switching to IgE
memory T cell
T cells that play a role in immunosurveillance (these cells have been previously activated)
Fas receptor (skip)
CD95 ligand (CD95-CD95L interaction leads to apoptosis)
NK cells
innate immune cytotoxic cell, primary role destruction of virally infected cells
osmotic lysis
altered ion flux leads ultimately to net flux of water in the cell and then cell rupture
perforin
a protein present in granules of NK cells and CD8+ cytotoxic cells (cause cell lysis)
raf kinase
initial kinase in a kinase cascade following activation of ras
Th0 cells
intermediate cell in the activation of Thp to either a Th1 or a Th2 cell
Th1 cells
CD4+ T cells that secrete Type 1 cytokines
Th2 cells
CD4+ T cells that secrete Type 2 cytokines
Thp cells
naive cells that have not yet been activated (T helper precursor)
TRADD (skip)
tumor necrosis factor receptor associated death domain
transforming growth factor beta
inhibitory cytokine
Type 1 cytokines
primarily required for cellular immunity
Type 2 cytokines
primarily required for humoral immunity
Zap 70 kinase
tyrpsine kinase that is activated when T cells are activated