Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
Polyenes
|
ergosterol synth.
broad fungiCIDAL form channels in membrane |
|
|
Azoles
|
ergosterol synth
broad fungistatic block synth. & weaken membrane |
|
|
Allylamines and thiocarbamates
|
effect ergosterol
broad fungistatic inhibit early ergosterol stop poorly absorbed topical |
|
|
Morpholines
|
effect ergosterol
broad fungistatic inhibit late ergosterol step topical nail infections |
|
|
flucytosine
5-fluorocytosine |
inhibit nuke acid synth
broad metabolite incorporated into RNA used in combo w/ polyenes (ampho B) |
|
|
Griseofulvin
|
inhibit nuke acid synth
broad bind microtubules; block mitosis deposit in keratinized tissue slow acting; 6 month treatment |
|
|
Echinocandin B
|
alpha-glucan blocker
inhibit cell wall biosynth effective against candida NARROW |
|
|
NARROW Spectrum againt P. Jirovecki
|
sulfonamides & trimethoprim-folate inhibitors
pentamidine-pneumocystic inhibitor blocks common comorbidity of AIDS |
|
|
Tetracycline
|
Antiprotozoals
inhibit protein synthesis |
|
|
Emetine
|
Antiprotozoals
inhibit protein synthesis |
|
|
Pyrimethamine-sulfadoxine
|
Antiprotozoals
inhibit folic acid synthesis |
|
|
Suramine
|
Antiprotozoals
interferes with trypanosomal glycolysis (glycosomes) |
|
|
Primaquine
|
Antiprotozoals
inhibits mitochondrial respiration |
|
|
Norfloxacin
|
Antiprotozoals
inhibits DNA gyrase |
|
|
Metronidazole
|
Antiprotozoals
must be activated causes DNA damage |
|
|
Chloroquine, quinacrine
|
Antiprotozoals
intercalates into DNA |
|
|
pentamidine
|
Antiprotozoals
Interacts with DNA of trypanosomal kinetoplast |
|
|
Praziquantel
|
antimetazoal
disrupts protective covering increases efficiency of eosinophils |
|
|
Pyrantel Pamoate
|
antimetazoal
depolarizes myoneural junction of roundworms |
|
|
Niclosamide
|
antimetazoal
inhibits oxidative phosphorylation in mitochondria |
|
|
Nebendazole; thiabendazole
|
antimetazoal
inhibit DNA synthesis |
