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30 Cards in this Set

  • Front
  • Back
B cell generate this segment as they mature
Antibody gene segment
One VDJ for heavy
One VJ for light
Transcription of antibody gene segments allows formation of :
antibody molecules with a single combining site specificity
"display" the antibody combining site a mature cell can make (allowing them to function in Ab responses)
B Cell Receptors
Two components of BCRs
membrane Ig (mIg) comprised of IgD and IgM monomers
and
Ig-alpha/Ig-beta heterodimers
Ig-alpha/Ig-beta heterodimers
disulfide-linked polypeptides containing cytoplasmic domains with ITAMs
ITAMs
Immunoreceptor Tyrosine-based Activation Motifs
change conformation due to mIg cross-linking
heterodimers
coexpressed on the surface of naive (virgin) mature B cells
IgD and IgM monomers
comprise the N-terminal domains of both heavy and light chains of BCRs
Variable domains containing three hypervariable (CD) regions
CDRs in variable domains of surface IgD and IgM bind
antigenic determinants of native antigen (which initiates capping)
capping
cross-linking of BCRs
comprise the membrane-proximal domains of heavy chains (BCRs)
constant domains
transmembrane regions (BCRs)
stretches of ~20 hydrophobic amino acids) near the C-terminal end of the heavy chains & anchor them (B cell cytoplasmic membranes)
nearly nonexistent at the C-terminal end of these heavy chains (BCR: IgM/IgG
cytoplasmic tails
Generates a signal that is transmitted to the B cell nucleus via an intracellular signal transduction pathway
ITAM phosphorylation
# of ITAMS in Igalpha and Igbeta
alpha: 2
beta: 1
based upon the recruitment of individual B cells, via their ability to specifically interact with an antigenic determinant, into a proliferating population of cells that eventually differentiates
clonal selection of B cells
T cells rearrange these segments:
Surface Receptor Segments
One VJ for alpha
One VdJ generated for beta
NOT secreted by T cells
TCRs
result from their specific interaction with antigen fragments via their TCRs
T cell proliferation, differentiation and cytokine production
two components of TCRs
TCR-alpha/TCR-beta heterodimers
and
CD3
comprise the membrane-proximal domains of TCR-alpha and TCR-beta
constant domain (transmembrane segments and cytoplasmic tails)
must be coexpressed with the alpha/beta heterodimers (TCRs)
CD3
polypeptides comprising CD3
gamma
delta
epsilon (in pairs)
zeta (disulfide-linked dimers)
link CD3 with the constant regions of alpha/beta herterodimers
charge-based (electrostatic) interactions
Zeta and epsilon both have cytoplasmic domains with:
ITAMS
zeta: 3
episilon: 1
TCR interaction with antigen fragments bound to MHC molecules on APCs initiates
ITAM phosphorylation by cytoplasmic protein kinases in T cells
generates a molecular "signal" that is transmitted to the T cell nucleus via an intracellular signal transduction pathway
(TCR)
ITAM phosphorylation
based on recruitment of individual T cells, via their ability to specifically interact with an antigenic fragment, into proliferating populations of T cells that eventually differentiates
clonal selection of t cells
ACRs used by APCs for presentation of antigen fragments to T cells
MHCs