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21 Cards in this Set
- Front
- Back
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Non-Hodgkins lymphoma
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Lymphocyte cancer
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Acute lymphoblastic leukemia (ALL)
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Children
(lymphoid) Bone marrow and blood Rapid increase immature lymphocytes |
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Pre-B cell leukemia
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(pre-B) Bone marrow and blood,
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Chronic lymphocytic leukemia (CLL)
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(activated/ memory B cell, adults)
(B1 postnatal, CD5 = self-renewal from cytokine IL-10) B1: diverse V repertoire, rearranged immunoglob N nucleotides |
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Follicular cell lymphoma
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(mature, memory B)
Mature B cells tumors grow in follicle of lymph nodes |
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Non-Hodgkins lymphoma
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Rituximab: monoclonal antibody treatment: anti-CD20 antigen
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Reed-Sternberg cells
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No antigen receptor b/c somatic mutation
Strange dendritic morphology |
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Multiple myeloma
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Plasma cell tumor in bone marrow
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Multiple myeloma
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Secrete monoclonal antibody (IgA/IgG)
Synth more light chain than heavy |
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Multiple myeloma
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Migrate and erode calcification, anemia/ neutropenia
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Hodgkin’s lymphoma
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(germinal center) peripheral circulation = mutated immunoglob.
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Hodgkin’s lymphoma
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Spleen/ lymph node/ bone marrow/ organs, 1st radiotherapy success
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Hodgkin’s lymphoma
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Cancer involved with Reed-Sternberg cells
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Epstein-Barr virus
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Chronic infected B cells divide repeatedly
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Epstein-Barr virus
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Mutate to Burkitt’s
(MYC gene regulates cell cycle but mutated Ig gene transformation and translocation) |
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Burkitt’s lymphoma
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(like germinal center B cell)
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Burkitt’s lymphoma
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latent infection, dsDNA Herpes
infected as adolescent= mononucleosis |
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Burkitt’s lymphoma
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EBNA-1 escapes effective proteosome processing (do not bind MHC I)
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Burkitt’s lymphoma
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MYC proto-oncogene on chromo 8 (regulates cell cycle) joined by translocation to immunoglob heavy chromo 14 or light chromo 22
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Acute lymphoblastic leukemia (ALL)
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Prevent production of other hematopoietic cells
No functional Ig |
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Chronic Lymphocytic Leukemia (CLL)
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slow mutation Ig depend on time of mutagenesis
Possible Association with Herbicides in Vietnam |
