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64 Cards in this Set
- Front
- Back
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macrophages secrete
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IL-1, IL-6, IL-8, IL-12, TNF
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macrophages have
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MHC II, B7, CD40, CD14
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Th secretes
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IL-2 through 6, IFN-g
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Th have
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CD3, CD4, CD28, CD40L
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B cells secrete
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IL-12
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B cells have
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B7, CD19 through 21, CD40, MHC II
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inhibits activated T cells
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IL-10, TGF-b
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neutrophil chemotaxis
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IL-8, C5a, LTB4, 5-HETE
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Th autocrine
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IL-2
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activates B cells
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IL-4, IL-5
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stem cell differentiation
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IL-3
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C: neutralizes virus
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C-1 through 4
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C: opsonization of bacteria
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C3b
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C: anaphylaxis
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C3a, C5a
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C: MAC
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C5b through 9
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activates Nk cells
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IL-12, IFN
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ANA
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SLE
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Anti-dsDNA, anti-Sm
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SLE
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Antihistone
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drug-induced lupus
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anti-IgG
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RA
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Anticentromere
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scleroderma/crest
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anti-Scl70
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scleroderma
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antimitochondrial
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PBC
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anti-BM
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goodpastures
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antimicrosomal
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hashimotos
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anti-Jo1
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myositis
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Anti-Ro, Anti-La
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sjogrens
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anti-smooth muscle
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AI hepatitis
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c-ANCA
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wegeners
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p-ANCA
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microscopic polyangitis
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tx: MS
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IFN-b
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tx: chronic granulomatous dz
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IFN-g
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cyclosporine
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blocks calcineurin, IL-2
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tox: cyclosporine
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nephro
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tacrolimus
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IL-2
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azathioprine
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purine synth inhibitor
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tox: azathioprine
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BM suppression
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muromonab
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prevents T cell activation
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sirolimus
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binds mTOR and T cell reponse to IL-2
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MMF
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blocks guanine synth
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daclizumab
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anti-IL-2 Ab
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infliximab
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anti-TNF
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LTC4, D4, E4
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bronchoconstriction, vasoconstriction, contraction of smooth muscle, ^ vascular permeability
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drug lupus pharmacokinetics
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N-acetylation
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Type 1 HS Ig?
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IgE
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Th secretes these at B cells to activate them
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IL4, 5
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Costimulatory signal involves these two proteins
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B7, CD28
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class switching CD
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CD40
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hereditary angioedema: mutation in
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C1 esterase inhibitor
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which cells are seen in hypersensitivity myocarditis?
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eosinophils
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which cells are seen in acute (1-4wk) rejection?
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T cells
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which cytokine is responsible for septic shock?
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TNFa
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CD14
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macrophage
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CD20
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B cells
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tolerance, negative selection mediated by __ cells, occurs in __ organ
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fetal T cells, thymus
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ADCC
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macrophages, NK, eosinophils
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this cytokine stimulates macrophages
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IFN-g
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MAC deficiency results in repeated infections of
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neisseria
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dendritic cell found in skin and mucous membrane is called
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langerhans
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cytochrome c in cytosol leads to
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apoptosis
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insulin resistance cytokine
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TNFa
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which cytokine activates eosinophils?
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IL-5 (the "anti parasite" IL)
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TNFa is induced by this transcription factor
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NF-kB
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