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15 Cards in this Set

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Muromonab-CD3:

Acute organ transplant rejection.
Contraindications:
- uncompensated CHF/volume overload risk of pulmonary edema.
Baxiliximab (SIMULECT)
CHIMERIC (mouse/human)
- Binds to the IL-2 receptor alpha chain CD25 on activated lymphocytes.
Daclizumab (ZENAPAX)
Humanizd monoclonal IgG that specifically binds to the alpha subunit, CD25 of the human IL-2 receptor.
Anti-thymocyte globulin, equine (ALTGAM)
Anti-thymocyte globulin, rabbit (THYMOGLOBULIN)
POLYCLONAL
- directed against cell surface markers
- antibodies block lymphocyte function by binding to cell surface molecules involved in the regulation of cell function.
Immunomodulators Agenst
Levamisole (ERGAMISOL)
Thalidomide (THALMID)
BCG (Bacillus Calmette-Guerin)
Aldesleukin (Proleukin)
Interleukin 11/Oprelvekin (Neumega)
Levamisole (ERGAMISOL)
- ADJUVANT TX w/ fluorouracil after surgical resection in pts w/ Dukes Stage C Colon Cancer.
Major A.E. of LEVAMISOLE
- Fatal agranulocytosis
- Taste and smell alteration.
Thalidomide (THALOMID)
ERYTHEMA NODOSUM LEPROSUM
BCG (Bacillus Calmette-Guerin)
M Bovis
Nonspecific immunostimulant or adjuvant
Aldesleukin (PROLEUKIN)
- Human recombinant IL-2
- TOXICITY: Capillary leak syndrome.
Interferons A.E.:
FLU-LIKE SYNDROME
Granulocyte colony-stimulating factor (G-CSF)

STIMULATES NEUTROPHIL PROD.
Filgrastim (NEUOPEGEN)
Pegfilgrastrim (Neulasta)
- LONGER HALF LIFE
Granulocyte macrophage colony-stimulating factor (GM-CSF)
Sargramostim (LEUKINE)
INDICATION FOR G-CSF AND GM-CSF:
1. Neutropenia following cytotoxic chemotherapy.
2. Bone marrow tranplantation
Palvizumab (SYNAGIS)
Approved for prevention of RESPIRATORY SYNCYTIAL VIRUS

S/E: Elevation of serum aminotransferase levels.