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5 Cards in this Set

  • Front
  • Back

Surface markers of t lymphocytes

CD 3(TCR)


Also CD 2,CD 4,CD 8,CD 11a,CD 40

Surface markers of b lymphocytes

Complement receptor


Fc receptor (APC)


EBV receptor CD21


CD40

Null cell /large granular lymphocyte surface markers

Fc receptor of igG CD16


NCAM1 receptor CD56


Some t lineage markers CD8,CD2


In NK/T cells CD3



Receptors


Killer cell inhibitory receptors KIRS + MHC 1


CD 94 NKG2 receptor + MHC 1b/ HLA E


Complement /alexine system(serum proteins- heat labile)

Activators


Classical pathway: M>G3>G1>G3


Alternate pathway:A1>A2>D>G4


C 3b3bi_ opsonin phagocytosis


C3a+C5a_ anaphylatoxin


C5a_+ lipo oxygenase pathway


Chemotaxis


Activation and adherence


C5b- 9_membrane attack complex cell lysis.


Origin:



Intestinal epitheliumMacrophagesSpleenLiver


Macrophages


Spleen


Liver


Major histocompatibility / transplantation compatibility

Chromosome 6 small arm


MHC complex molecules


1-on nucleated cells and platelets


2-on APC


3-complements C2C4(CL),properdin factor b(AL),heat shock protein,TNF a and b


Antigenic binding site


1- by a1 and A2


2-by a1and b1