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21 Cards in this Set
- Front
- Back
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A successfull immune response requires recognition of ________by _______ or receptors on B and T cells.
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antigen
Antibody |
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What are the 3 APCs?
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B Cells
Macrophage Dendritic cells |
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What kind of Th present to each one (mature? naive?)
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B cells present to mature Th.
Macrophages present to mature Th Detritic cells present to naive Th. |
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CD4+ T cells become...
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Th or Treg
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CD8+ TC become...
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Tc cells.
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CD4+ Th1 help development of what kind of cells?
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Tc
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CD4+ Th2 cells help the develop,ent of what kind of cells?
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B-cells
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Based on the last 2 questions, __ help in cell-mediated immunity and ___ help in humoral immunity.
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Th1, Th2
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5-7 days into a primary immune response, what Ig shows up first?
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IgM
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With a secondary response, what differs?
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Faster because memory cells are already differentiated, more amts of antibody made, IgM same amt but more IgG
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Type I hypsersensitivity involves ____, is directed against ____ and involves _______ release from mast cells.
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IgE
Allergens (envtal antigens) Histamie release |
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Type I: Antigen presents to _____ cell which processes it and shows it to the ___ which secretes Il4 and Il5 which causes a class switch of the ____ and ___ secretion.
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dedritic cell
Th2 BC, IgE secretion |
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The IgE coats the surface of the ______ cell at the ___ receptor.
The mast cell then ______ releasing _____ into the area. |
Mast cell at FC receptor.
Degranulates, releasing hystamine and eosinophil Chemotact factor. |
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Type 2 hypersinsitivity reactions are ______ specific.
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Tissue
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Cells can be destroyed by 5 mechanisms with type 2 reactions, what are they?
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Cell destruction by antibodies and complement
Cell desruction via phagocytosis SOluble antigen enters circulation and deposits in tissues Antibody dependedn cell mediated cytotox. Target cell malfunction. |
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ABO incompatiblity is an example of what type of rxn?
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Type 2
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Type 3 hypersensitivity rxns are called ...because....
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Immunie complex mediated because antigen-antibody complexes are formed in ciruclation and later deposited in vessel walls or extravascular tissues
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Serum sickness and arthus reactions are examples of what kind of reaction?
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Type 3
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Type 4 reactions do not involve _______.
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ANtibody.
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What immune cells are involved iwth type 4reactions?
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Tc or lymphokine secreting Th1 cells (to recruit pahgocytes).
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What are some examples of type 4 delayed hypersensitivity reactions?
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Poison ivy, acute graft rejection, PPD, contact alllergies
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