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27 Cards in this Set
- Front
- Back
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serology
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study of reactions b/w antibodies and antigens
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antiserum
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generic term for serum b/c it contains Ab
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globulins
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serum proteins
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immunoglobulins
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antibodies
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gamma globulin
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serum fraction containing Ab
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naturally acquired active immunity
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result from infection
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naturally acquired passive immunity
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transplacental or via colostrum
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artificual acquired active immunity
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injection of Ag (vaccination)
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artificially acquired passive immunity
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Injection of Ab
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NK cell
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leukocytes destroy cells that don't express MHC 1
kill virus infected and tumor cells attack parasites |
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Treg
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T regularotry cells
CD4 and CD25 on surface suppress T cells against self |
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T lymphocytes
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prod in red bone marrow
mature in thymus circulate in lymph and blood migrate to lymph nodes, spleen, peyers patch part of cell-mediated immune response act directly against various Ag |
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Classes of T cells
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Helper T
Cytotoxic T |
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helper T
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CD4
MHC 2 recognize Ag on surface of macrophage and activate macrophage dendritic cells activate CD4 Tcells Th1 produces IFN gamma Th2 activate eosinophils and B cells to produce IgE |
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Cytotoxic T
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CD8
MCH 1 precursor to CTLs activated by cytokines fr helper T cell |
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TCR
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recognition of antigens by T cell requires process by antigen presenting cells
dendritic cells macrophages |
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dendritic cells
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long extensions of the membrane are dendrites
in lymph nodes, spleen, skin poorly phagocytic - good for APC |
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macrophages
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found in resting state
initiated by ingestion of antigenic material or cytokines appearance different - ruffled look after activation - migrate to lymph nodes and mucosa presen antigen to T cells there |
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M cells
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in microvilli on epithelial cell
allow transfer to lymphocytes and Ag presenting cells of immune sys thru GI IgA formed and migrate to mucosal lining facilitate contact b/w Ag and immune |
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MHC
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Ag presentation
Ag detected by Tcell |
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MHC 2
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stimulate T helper and cytotoxic
dendritic cells, B cells + macrophages are APC's that present to Tc & Th for engulfed microbe |
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MHC 1
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all cells have
shows if contaminated or not Display Ag to Tc |
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Cytokines
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chemical messengers
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IL1
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stimulate T helper w/ Ag
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IL2
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proliferation of CD4 T helper; B cells; activate CD8 T cells & NK cells
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TNF alpha
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promotes inflammation
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IFN beta
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stimulate macrophage activity
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