Immune System & Cells Of Immune System (Lecture 2)

Front 1

Which immunity is non-specific?

Back 1

Innate immunity

Front 2

What are the components of the first line of defense (innate)?

Back 2

-skin

-mucuous membrane & secretions

-normal microbiota

Front 3

What are the components of the second line of defense (innate)?

Back 3

- phagocytic WBC

- inflammation & fever

- antimicrobial substances

Front 4

What are the components of the third line of defense (adaptive)?

Back 4

- lymphocytes (B & T cells)

- antibodies

Front 5

What are the TWO components of the adaptive immunity?

Back 5

1) Humoral

2) cell-mediated

Front 6

which (innate or adaptive) immunity fast & fixed response?

Back 6

innate

Front 7

Which (innate or adaptive) immunity response CONSTANTLY throughout the immune response?

Back 7

innate

Front 8

Which (innate or adaptive) immunity has an improving response during the infection?

Back 8

adaptive

Front 9

Number of microorganisms vs. duration of infection graph shows the # of microorganisms constantly increasing. Which immune system is lacking?

Back 9

lacking innate immunity only

Front 10

Number of microorganisms vs. duration of infection graph shows the # of microorganisms increases then stabilizes. Which immune system is lacking?

Back 10

lacking adaptive immunity only

Front 11

Number of microorganisms vs. duration of infection graph shows the # of microorganisms increases then decreases. Which immune system is lacking?

Back 11

none (normal human)

Front 12

where do B cells develop?

Back 12

-primary lymphoid organs

1) Fetal liver

2) Adult bone marrow

Front 13

site of hematopoietic activity in fetus

Back 13

liver & spleen

Front 14

site of hematopoietic activity in adult

Back 14

bone marrow (long bone, cranium, pelvis, sternum, ribs, vertebra)

Front 15

characteristics of hematopoietic stem cells from bone marrow?

Back 15

1) undifferentiated
2) pluripotent
3) self-renewing

Front 16

where do B & T cells and NK cells come from?

Back 16

lymphoid progenitor cell

Front 17

What does the myeloid progenitor cell become?

Back 17

macrophage, monocyte, neutrophil, eosinophil, basophil, platelet, RBC

Front 18

where does RBC come from?

Back 18

myeloid progenitor cell

Front 19

which leukocyte is the most abundant in blood?

Back 19

neutrophil

Front 20

what cellular components of the macrophage contain microbe-killing enzymes? what does it contain?

Back 20

lysosome

peroxidase & hydrolases

Front 21

what are the polymorphonuclear cells?

Back 21

neutrophils, eosinophils, basophils

Front 22

cytoplasmic granules stain with acidic dye

Back 22

eosinophil

Front 23

cytoplasmic granules stain with basic dye

Back 23

basophil

Front 24

what does the platelet do?

Back 24

1) blood clot & inflammation

2) increase capillary permeability

3) activate complement

Front 25

which cell kills virus infected cells?

Back 25

NK cells

Front 26

where are the Antigen Presenting Cells found?

Back 26

skin, lymph nodes, spleen, underneath mucosal epithelium, thymus

Front 27

types of APC?

Back 27

1) Langerhans cell
2) Follicular dendritic cells (FDC)
3) interdigitating dendritic cells (IDC)
4) B cells & macrophages

Front 28

Are B cells & macrophages APC?

Back 28

yes

Front 29

what does a B cell differentiate into?

Back 29

1) memory cell

2) plasma cell

Front 30

What does a T cell differentiate into?

Back 30

1) CD4 (T-helper1 & T-helper 2)

2) CD8 (cytotoxic)

Front 31

What is responsible for the humoral immunity? Why?

Back 31

B bells
--> surface receptors (Ig) are soluble.

Front 32

what does T-helper cell do? What's its CD #?

Back 32

produces cytokines & direct immune responses

CD4