Immune System

Front 1

What are 2 functions of the immune system?

Back 1

to recognizes and attack specific foreign molecules –antigens
Diffuse lymphoid tissue and lymphoid organs

Front 2

What are the key cells of the immune system?
What are they supported by?

Together they make up the?
Describe circulating lymphocytes

Back 2

lymphocytes
Connective tissue cells
lymphoid tissue

travel from blood to lymphoidtissues and back to blood

Front 3

Describe 3 types of lymphocytes

Back 3

B lymphocytes – upon activation secrete antibodies

• T lymphocytes – upon activation attack and directlydestroy virus-infected and foreign cells

• Natural Killer cells – cytotoxic lymphocytes, use nonspecificrecognition; directly destroy “non-self” cells, tumorand virally infected cells

Front 4

List the 5 stages of T and B cells

Back 4

1. origin- arise in red marrow
2. maturation- T travel in blood and mature in thymus; B remain in marrow and mature there
3.Seeding secondary lymphoid organs and circulation- Immunocompetent but naive lymphocytes leavethe thymus and bone marrow• They “seed” lymphoid tissues and organs andcirculate through blood and lymph

4. Antigen encounter and activation• When a lymphocyte’s antigen receptors bindits antigen, that lymphocyte can be activated

5. Proliferation and differentiation• Activated lymphocytes proliferate and differentiateinto effector cells (antibody producing or cytotoxiccells) and memory cells

Front 5

Describe lymphoid tissue.
Where is it located?

Back 5

Specialized type of connective tissue, containing large amountsof lymphocytes

Mucous membranes of respiratory, digestive, urinary, andreproductive tracts

• Lymphoid organs (Lymph Nodes, Spleen, Thymus)

Front 6

Where is the thymus?
What occurs here?
When is it most active?
When does it function?
Does it fight infections directly?
What is the function of the thymus-blood barrier?

Back 6

-Located in mediastinum, between sternumand great vessels of the heart
-T lymphocyte maturation
-during childhood
- during lymphocyte maturation
-No
- protects immature Tlymphocytes from exposure to antigens

Front 7

What is the largest lymphoid organ?
(Hint: Has LARGE blood supply)
What is its MAIN function?
What other 2 functions does it perform?

Back 7

spleen
filter blood
1. Removal and destruction ofold/defective blood cells

2. Removal of blood-borne antigens(immune surveillance)

Front 8

What are tonsils?
Where are they located?
What is their function?
Name 4 types

Back 8

Small aggregations oflymphoid tissue
Arranged in a ring aroundthe entrance to the pharynx(throat)
to gather andremove pathogens frominspired air and ingestedfood

tubal, pharangyeal (adenoids), palatine, lingual

Front 9

Mucosa-Associated Lymphoid Tissue - MALT
What is the function of mucosa?
Where can it be found?
Where is MALT ESPECIALLY abundant?

Back 9

lines body cavities open to the exterior
digestive, respiratory, reproductive and urinarytracts

walls of intestines and in appendix - (at the beginning of large intestines)lymphoid tissue occupies over ½ of its thickness