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9 Cards in this Set
- Front
- Back
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why can't we develop vaccines to parasites?
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difficult to develop longterm immunity to parasites because of their diverse life cycle
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nonspecific response to parasites
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EOSINOPHILS and mast cells (degranulation attacks cuticle)
complement: if have PM (protozoans) can form MAC; MAC not effective on helminth but can still opsonize phagocytes- protozoans and helminth larvae |
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specific response to parasites
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TH1: DTH, CTL, ADCC (intracell)
TH2: opsonization, C' activation, ADCC (extracell) |
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Leishmania species: general charac
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flagellated protozoan
reservoirs: dogs, cats, rodents, humans transmission: sand-fly (arthropod) |
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Leishmania species: clinical disease
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cutaneous: L.Tropica- ulcerating skin sores
heal with scars b/c bystander damage mucocutaneous: L.braziliensis- extreme damage due to immune response (destruction of cartilage and skin) visceral: L.donovanni |
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prevention, resolution leishmania species
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innate- inflamm
adaptive- prevention:memory DTH to 2ndary infection (not primary) opsonizing Ig-if dont downreg TH1, block adherence before establish 2ndary infection resolution-DTH and strong TH1 |
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taenia saginata: general charac
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helminth: beef tapeworm
transmission-ingest larvae in raw beef host-humans are definitive host (adult and sexual life) |
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clinical disease: taenia saginata
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infects intestines
most infections asymptomatic disease: anorexia (due to obstruction) and diarrhea |
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prevention and resolution:Taenia saginata
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innate- inflamm (eosinophils)
adaptive- prevention: memory DTH? MPh can phagocytize fragments from degraulation resolution: NOT POSSIBLE; TRYO TO CONTROl BURDEN TH1 and strong cell mediated-self limiting TH2-disseminated |
