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36 Cards in this Set
- Front
- Back
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Blood Transfusion Reaction |
Type II Hypersensitivity Mechanism= Opsonization (IgG) |
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Erythrblastosis Fatalis |
Type II Hypersensitivity Reaction Mechanism= Opsonization |
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Autoimmune Hemolytic Anemia |
Type II Hypersensitivity Reaction Mechanism= Opsonization |
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Agranulocytosis |
Type II Hypersensitivity Reaction Mechanism= Opsonization |
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Thrombocytopenia |
Type II Hypersensitivity Reaction Mechanism= Opsonization |
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Pemphigous Vulgaris |
Type II Hypersensitivity Reaction Mechanism= Complement- Fc receptor -desmosome disruption -blistering
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ANCA Vasculitis |
Type II Hypersensitivity Reaction Mechanism= Complement- Fc receptor -degranulation of neutrophils in muscular wall of epithelium |
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Goodpasture Syndrome |
Type II Hypersensitivity Reaction Mechanism= Complement- Fc receptor |
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Hemorrhagic Fever |
Type II Hypersensitivity Reaction Mechanism= Complement- Fc receptor |
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Myesthenia Gravis |
Type II Hypersensitivity Reaction Mechanism= ADCC |
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Graves Disease |
Type II Hypersensitivity Reaction Mechanism= ADCC |
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Systemic Lupus Eryhtematosus |
Type III Hypersensitivity Reaction (systemic) Autoimmune -ANA (anti-dsDNA, anti-Smith antigen) -malar butterfly rash -nephritis -CNS -splenomegaly -Libman-Sacks endocarditis -Pleural effusion -arthritis
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Post-streptococcal Glomerulonephritis |
Type III Hypersensitivity Reaction (systemic) -"planted" streptococcal antigens in the glomerular basement membrane
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Polyarteritis Nodosa Vasculitis |
Type III Hypersensitivity Reaction (systemic) |
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Reactive Arthritis |
Type III Hypersensitivity Reaction (systemic) |
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Arthus Reaction |
Type III Hypersensitivity Reaction (localized) -occurs at vaccination site |
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Multiple Sclerosis |
Type IV Hypersensitivity Reaction |
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Diabetes Mellitus Tye I (insulitis) |
Type IV Hypersensitivity Reaction |
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IPEX |
childhood autoimmune disease -FOXP3 mutation -t-regulatory cell dysfunction |
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ALPS |
childhood autoimmune disease -FasL defect -peripheral tolerance development via activated cell-induced apoptosis is not possible |
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Sjogren Syndrome |
autoimmune -lymphocytic infiltration of endocrine glands: -salivary--> xerostomia -lacrimal--->xeropthalmia -ANAs: anti-ro (SSA) and anti-la (SSB) indicative of early onset and longer duration -increased risk of lymphoid malignancy -association with ebv, HIV-1, HTLV-1
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Scleroderma |
-autoimmune -anti-topoisomerase (SCL-70)--> systemic -malignant hypertension=> kidneys -anti-cerntromere--> CREST C=calcinosis R=Raynauds Phenomenon E=Esophageal Dysmotility S=Sclerodactyly T= Telangiectasia |
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Mixed Connective Tissue Disease |
-indicators of SCL, Scleroerma, and polymyositis -high titers of antibodies to RNP -no renal disease -responsive to corticosteroids
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Hypogammaglobulinemia |
-primary immunodeficiency -B cell deficiency -general Ab deficiency -recurrent bacterial infections -higher risk for gastric carcinoma and lymphoma
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Brutons X-Linked Agammaglobulinemia |
-B cell deficiency -x-linked -BtK mutation -inability of B cells to mature from pre-b cells -lack of germinal centers recurrent pyogenic infections -increased risk of colonic carcinoma |
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Isolated IgA deficiency |
-b cell deficiency -most common primary ID -frequently asymptomatic -prone to GI and sinonasal infections
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DeGeorge's Syndrome (thymic apasia) |
-T cell deficiency -3rd and 4th pharyngeal arch do not develop -lack of thymus and parathyroid -low CD3+ cell counts--> no cell-mediated response -hypocalcemia--> tetany -poor defense against fungal/ viral infections (no CD8) -abnormal facies, congenital heart defects |
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SCID |
-combined -ADA deficiency (purine synthesis) or common gamma chain mutation (IL-2 receptor) -infants with recurrent severe infections - treatment= bone marrow transplant |
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Wiskott Aldrich |
-combined -x-linked -cellular defect in actin cytoskeleton/ glycoprotein on B and T cells -thrombocytopenia -reduced lifespan of T cells -pyogenic infections -bleeding -eczema (peri-oral and peri-ocular)
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Hyper IgM Syndrome |
-combined -x-linked -CD40L defect--> no class switching -recurrent bacterial infections -infancy- recurrent respiratory tract bacterial infections, opportunistic infections, recurrent or protracted diarrhea -increased risk for hodgkins lymphoma (EBV) |
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Chronic Granulomatous Disease |
--x-linked -phagocytic ID -NADPH-oxidase deficiency -recruitment of macrophages and t cells--> granulomas -hepatosplenomegaly and lymphadenopathy -diagnosis= nitroblue tetrazolium
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C3 deficieny |
-increased bacterial infections |
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C1q, C2, C4 |
-immune-complex- mediated diseases (classical pathway) |
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C1 esterase inhibitor |
-hereditary angioedema |
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DAF deficiency |
-paroxysmal nocturnal hemoglobinuria |
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C5-C9 deficiency |
-nesseiria and meningococcal infections |
