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112 Cards in this Set

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c-myc
burkitt's
(oncogene)
bcl-2, fxn
follicular and undifft,
fxn=inhib apoptosis
(oncogene)
erb-B2
breast, ovarian, gastric
(oncogene)
ras
colon
(oncogene)
L-myc
lung
(oncogene)
N-myc
neuroblastoma
(oncogene)
Rb
13q, retinoblastoma and osteosarcoma
if a person comes in with one, check for the other!
(oncogene)
BRCA1,2
17q,13q breast, ovarian
(tumor suppressor)
p53
17p, most human cancers, Li Fraumeni syn
(tumor suppressor)
APC
5q colorectal
(tumor suppressor)
NF1,2
17q,22q NF1,2
(tumor suppressor)
DPC
18q, pancreatic
(tumor suppressor)
DCC
18q colon (+gastric?)
(tumor suppressor)
name genes assoc colon ca
ras (oncogene), APC, DCC (both tumor suppressors)
bombesin
neuroblastoma, lung, gastric tumor marker
antimicrosomal Ab
Hashimoto thyroiditis
antimitochondrial
PBC
anticentromere
Scleroderma, CREST
AntiIgG
RF
IL1
sxn by macro,
+T, B, PMN, fibro, epithelial
endogenous pyrogen
IL2
sxn by Th
+Th,T (also B?)
IL3
sxn activ T
growth diffn BM (like GM-CSF)
IL4
SXN Th
+IgE, IgG
IL5
sxn Th
+ IgA
IL8
sxn ?
major chemotactic for PMN
gamma IFN
sxn by Th
stimulates Macrophages
TNF alph
sxn macro
Th: incr IL2 R
B: prolifer
PMN: attract, activate
TNF beta
sxn activ T
similar to TNF alpha
Th: incr IL2 R
B: prolifer
PMN: attract, activate
Th surface markers
CD3,4,28
TCR
T surface markers
CD3,8
TCR
B cell's surface markers
CD19,20
B7, IgM
macro surface markers
CD14, MHCII
NK cell surface markers
R for MHCI, CD16
who has MHCI
all cells except mature RBC
cytokines secreted by Th
IL2,4,5, gammaIFN
cytokines secreted macro
IL1, TNFalpha
what stimulates macro
gamma IFN (sxn by Th)
Th cell activation: costimulatory signal
B7,CD28
(B7 is on APC, CD28 on Th cell)
when Th activated what secrete
IL2, gamma IFN
what cytokine makes Th1? Th2?
Th1=IL 12
Th2=IL4
1
1
Th2 sxns? fxn?
IL4,5 B cells difft into plasma cell
(Ab immunity)
TH1 act on?
activated macro (gamma IFN)
activated T (IL2)
(cell immunity)
allotype v isotype v idiotype
allotype=Ig epitope differs among species
isotype=IgG,IgA, etc, the heavv chain common to the class
idiotype=specific Ag (binding site)
compare MHCI,II in terms of R
MHCI=1 polypeptide with beta-2 microglobulin
MHCII=2 polypeptides, alpha, beta chain
where MHCI,II loaded
MHCI=RER (viral Ag)--all nu cells
MHCII=acidified endosome
name one allergy B cell mediated and one T
B cell=hay fever, etc
T cell=poison oak
when do you really need T cells
TB, virus infected cells, fungi
complement: C3b
opsonization
complement: 3a, 5a
anaphylaxis
complement: defic C1 esterase
hereditary angioedema (overactive complement)
complement: defic C6-8
Neisseria bacteremia
defic DAF, what does it stand for
PNH
DAF=delay activating factor
alternative pathway starts w
C3
Type I hypersensit
Anaphylactic and Atopic (rapid)
Ag binds IgE on mast->degran
ex. anaphylaxis, asthma, hives, wheal and flare
complement: C1-4
viral neutralization
complement: C3 defic
severe recurrent pyogenic snus and respir ifxns
general role of interferons, then 3 specific roles
put un-infected cells on alert
-alpha, beta inhibit degrade viral mRNA
-gamma incr MHC1,II expression and Ag presentation
-activates NK to kill the viral infected cells
name 3 bac w Ag variation
Salmon-2 flagellar
Borrelia-relapsing fever
N gonorrhea-pilus protein
name parasite w Ag variation
trypanosomes (programmed rearrangement)
Type II Hypersensit, ex
Cytotoxic, IgM or IgG bind enemy, then either complement lysis, or phago
ex. AIHA, Rh dz, Goodpasteur, Rheumatic Fever, Graves, bullous pemphigoid
Type III Hypersensit
=IC, serum sick, arthus
immune complex-Ag/Ab complexes activate complement, bringing PMN
(think of 3 things stuck together)
ex=PAN, IC GN, SLE, RA
Serum Sickness
type III (w IC, arthus)
Ab formed ag foreign proteins (takes 5 d), then complement fixed->tissue damage
sx: fever, urticaria, arthralgias, proteinuria, LAD
Arthus rxn
local subacute hypersensiti (III), form AgAb complexes in skin, activ complement
sx: edema, necrosis
ex Arthus
hypersensitivity pneumonitis from actinomycetes
Hypersens IV, ex
delayed (cell mediated) sensitized T encounter Ag and rel lymphokines which activ complement
ex=TB,touching (contact dermatitis) ,transplant rxns
How to remember the hypersensitivities
ACID
RA which type
III
hives which type
I
asthma which type
I
Goodpasteur which type
II
rheumatic fever which type
II
bullous pemphigoid which type
II
PAN which type
III
SLE which type
III
wheal and flair which type
I
urticaria which type
part of III serum sickness
contact dermatitis which type
IV
PPD which type
IV
symptoms serum sickness, usu cause
F, urticaria, arthralgias, proteinuria, LAD 5-10 d after Rx
what usu activates alternate complement
endotoxin (remember classic is IgG, IgM
name gene types for MHCs
I=A,B,C
II=DP,DQ,DR
what's IgD
we don't know, on surface many B cells and in serum
when give passive immunity (preformed Ab's)
Tetanus, Botulinum, HBV, Rabies (To Be Healed Rapidly)
dangerous infxns preg
ToRCHeS
toxoplasma, rubella, CMV, HSV/HIV, syphilis
tuberous sclerosis facial (angiofibroma, sz, MR) assoc w
astrocytoma and cardiac rhabdomyoma
what's tuberous sclerosis
facial angiofibroma, sz, MR
Paget's dz assoc w
2 osteosarcoma and fibrosarcoma
acanthosis nigricans assoc w
visceral malig (stomach, lung, breast, uterus)
name for benign teratoma
mature teratoma
name for epithelail cancers? mesenchymal?
epithel=carcinoma
mesench=sarcoma
which type of cell proliferations are reversible
-metaplasia (irritation)
-dysplasia (pre cancer)
difft bw dysplasia, anaplasia, neoplasia
dysplasia=loss cell orient, shape, etc (preneo, reversible)
anaplasia=cells lacking difftn
neoplasia=clonal prolifer uncontrolled, excessive
diff hyperplasia, metaplasia
hyperplasia=incrse number cells
metaplasia=1 adult cell type replaced by another, often due to irritation or environ exposure
which is usu more px: stage or grade?
stage
remember TNM system (Tumor sie, Nodes, Mets)
HLA B27 assoc w
PAIR
Psoriasis
Ankylosing spondylitis
IBD
Reiters
HLA B8 assoc w
Graves, Celiac sprue
HLA DR2
MS, hay fever, SLE, Goodpasteur
HLA DR3
DMI
HLA DR4
DM2, RA
HLA DR5
Pernicious Anemia, Hashimoto's thyroiditis
HLA DR7
steroid responsive nephrotic
HLA type for RA
DR4
HLA type for Graves
B8
HLA type for Goodpasteur
DR2 (along w MS, hay fever, SLE)
HLA type for SLE
DR2 (along w MS, hay fever, Goodpasteur)
HLA type for celiac sprue
B8
HLA type for MS
DR2 (along with hay fever, Goodpasteur, SLE)
HLA type for steroid-responsive nephrotic syn
DR7
HLA for psoriasis
B27
PAIR
Psoriasis
Ankylosing spondylitis
IBD
Reiters
HLA for IBD
B27
PAIR
Psoriasis
Ankylosing spondylitis
IBD
Reiters
HLA for Reiters
B27
PAIR
Psoriasis
Ankylosing spondylitis
IBD
Reiters