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17 Cards in this Set

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imidazole- moa
inhibit sterol synthesis in fungal cell membranes
increase cell wall permeability

fungistatic
substituted imidazole derivatives
ketoconazole
miconazole
fluconazole
itraconazole
activity
fingi incl yeats, dermatophytesm actinomycetes phycomycetes
ketoconazole use
systemic and vacinal candidiasis, mucocandidiasis, candicuria, oral thrush, histoplasmosis, cocccidiodomycosis, chromomycosis, dermatophytosis(tinea), and paracocciodioidomycosis
miconazole use
vulvovaginal candidiasis
ringworm
skin infxn
parenteral ketoconazole
2nd line agent - severe systemic fungi infxn
fluconazole use
sustemic and cns infxn
cryptococcus and candida
itraconazole use
systemic and invasive pulmonary aspergillosis without the hematological toxicity of amp B
voriconazole use
fungal infxn
invasive aspergillosis
interaxn
ketoconazole and miconazole
enhance anticoagulant effect of warfarin
ketoconazole
antagonize the abx eff of amp b
fluconazole
elecate serm levels of phenytoinm cyclosporinem warfarin and sulfonylureas
hepatic enzyme infucer
rifampin

inc elimination of fluconazole and itraconazole
adequate absorption of ketoconazole and itraconazole
presence of stomach acid
ketoconazole + cisapride
inc conc of cisapride = torsades de pointes -> death
voriconazole
cytochrome p4502c19

major enzyme involve in metabolism
voriconazole inhibits
cytochrome p4502c19, cyp2c9, cyp3a4