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17 Cards in this Set
- Front
- Back
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imidazole- moa
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inhibit sterol synthesis in fungal cell membranes
increase cell wall permeability fungistatic |
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substituted imidazole derivatives
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ketoconazole
miconazole fluconazole itraconazole |
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activity
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fingi incl yeats, dermatophytesm actinomycetes phycomycetes
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ketoconazole use
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systemic and vacinal candidiasis, mucocandidiasis, candicuria, oral thrush, histoplasmosis, cocccidiodomycosis, chromomycosis, dermatophytosis(tinea), and paracocciodioidomycosis
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miconazole use
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vulvovaginal candidiasis
ringworm skin infxn |
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parenteral ketoconazole
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2nd line agent - severe systemic fungi infxn
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fluconazole use
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sustemic and cns infxn
cryptococcus and candida |
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itraconazole use
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systemic and invasive pulmonary aspergillosis without the hematological toxicity of amp B
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voriconazole use
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fungal infxn
invasive aspergillosis |
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interaxn
ketoconazole and miconazole |
enhance anticoagulant effect of warfarin
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ketoconazole
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antagonize the abx eff of amp b
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fluconazole
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elecate serm levels of phenytoinm cyclosporinem warfarin and sulfonylureas
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hepatic enzyme infucer
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rifampin
inc elimination of fluconazole and itraconazole |
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adequate absorption of ketoconazole and itraconazole
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presence of stomach acid
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ketoconazole + cisapride
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inc conc of cisapride = torsades de pointes -> death
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voriconazole
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cytochrome p4502c19
major enzyme involve in metabolism |
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voriconazole inhibits
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cytochrome p4502c19, cyp2c9, cyp3a4
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