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58 Cards in this Set

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Virus families with double stranded DNA
Herpes
Hepadeno
Adeno
(Parvo-actually ss)
Papova
Pox
(not Picorna or Paramyxo)
"Happy"
Members of Herpes virus family
Double Stranded, Enveloped, Icosahedral
Herpes simplex
Varicella
EBV
CMV
HHV-6 & 8
HSV
double stranded, enveloped,
dx w/Tzank or immunoflouresc
acyclovir (b/c thymadine kinase- also in Varicella)
EBV
double stranded, enveloped
infect B lymphocytes
Burkitt's & Nasal Carcinoma
Hairy Oral Leukoplakia
(in immunocomp'd)
splenomegaly & reactive T cells
CMV
double stranded, enveloped
in AIDS & transferred via
breast milk
Ganciclovir
HHV 6 is associated with...
Roseola
HHV 8 is associated with...
Kaposi Sarcoma
Characteristics of Adenovirus
double stranded, naked, icosahedral
penton fibers are attachment
sites
travel & replicate in nodes
Characteristics of Papova
double strand, circular DNA
naked, icosahedral
Papilloma virus (HPV) is
family member
HPV
member of Papovavirus family
serotype 16 & 18 associated with cervical Ca
Characteristics of Pox Virus
Complex structure
Largest virus
linear, ds, DNA, enveloped
RNA AND DNA polymerase
replicate in cytoplasm
members of Pox family
Variola (small pox)
Molluscum Contagiosum
Characteristics of Hepadenavirus
ds, enveloped DNA
includes HBV
Characteristics of Parvovirus
sm, ss DNA
serotype B19 is the only
human pathogen
Fifth Disease
Fifth Disease
caused by a Parvovirus
slap cheek rash
aplastic crisis w/chronic
hemolytic dz- (thalassemia
anemia)
Hydrops Fetalis
RNA Virus Characteristics
Replicate in Cytoplasm except
influenza & retrovirus
Single Stranded except Reo
Enveloped except Reo, Calci &
Picorna
Antisense (neg strand) are
all helical, enveloped, ss
DNA Virus Characteristics
Replicate in Nucleus except
Pox
Double stranded except Parvo
(hepadeno has ss regions)
Icosahedral except Pox
RNA Virus Families
Ico, Enveloped, SS
Toga & Flavi
Ico, NE, ds- Reo
Ico, NE, ss- Picorna & Calci
Helical, E, SS- ROBCRAP
Rhabdo, Ortho, Bunya, Corona, Arena, Paramyxo
Retro
Characteristics of Picornavirus
ss, +RNA, naked
Entero: polio, coxsackie, echo & entero
Rhino- common cold (w/adeno)
PEECRno
Poliovirus
member of Picorna
binds Rs in gut & neurons
polycistronic (proteases)
flaccid paralysis
Echovirus
member of Picorna
throat infections in summer
months
Coxsackie Virus
member of Picorna
epidemics in summer & fall
may cause meningitis
A- "Hand-Foot-Mouth"
B- myocarditis
Enterovirus
member of Picornavirus
72 is causative agent for
Hep A
Rhinovirus
member of Picorna
causes cold (like adeno)
Characteristics of Orthomyxo Family
-RNA, ss, segmented, enveloped
Influenza A & B
Influenza A & B
members of Orthomyxo family
segmented RNA
M (matrix)protein- maturation
NM (nucleocapsid) protein
Hemagluttin & Neuramidase are
targets for immune response
B associated with Reyes synd
Treatment for influenza
A- amantadine & rimantadine
A & B- oseltamivir & zamivir
rifampicin is for MTB
rinitidine is H2 blocker
Characteristics of Paramyxovirus
-RNA, enveloped
initial infection via resp
most common cause resp inf in children
HN protein (neuraminidase & hemagglutinin)- attachment
M protein- inner layer
F protein- fusion & hemolytic
Members of Paramyxovirus Family
Parainfluenza- croup
Measles (rubeola)
Mumps
RSV
Parainfluenza Virus
member of paramyxovirus
causes croup
Measles Virus
member of paramyxovirus
fever & maculopapular exanthem
Koplik spots- bluish-white specks on red base in buccal mucosa
coryza, conjunctivitis & cough
Mumps Virus
member of Paramyxovirus
vaccine is live attenuated
RSV
member of paramyxovirus
primary cause lower resp inf in infants
aerosolized droplets & fomites
Characteristics of Togavirus
+RNA, ss, enveloped
glycoprotein hemagglutinins in envelop
Members of Togavirus family
Alphavirus- EEE & WEE- arthropod-borne, spred via insect vector
Rubivirus (Rubella)- can transmit across placenta
Characteristics of Flavivirus
+RNA, ss, enveloped
similar to Togavirus
arthropod-borne
Members of Flavivirus family
Yellow Fever- mosquito
Dengue Fever- mosquito

St. Louis encephalitis
Yellow Fever
member of Flavivirus family
mosquito borne
hepatitis & hemorrhagic
(like dengue)
Dengue Fever
member of Flavivirus Family
mosquito borne
hepatitis & hemorrhagic
(like yellow)
St. Louis Encephalitis
member of flavivirus family
arthropod borne
CNS symptoms
Characteristics of Bunyavirus
-RNA, ss, enveloped
arthrpod vectors
members of Bunyavirus
California Encephalitis
Hanta
California Encephalitis
member of bunyavirus
-RNA, ss, enveloped
abrupt fever, bifrontal HA
arthropod vector
Hanta Virus
member of Bunyavirus
-RNA, ss, enveloped
hemorragic fever & ARDS
Characteristics of Rhabdoviruses
bullet shaped enveloped -RNA
ss
nucleocapsid w/glycoprotein spikes
replicates in cytoplasm
Rabies
Member of Rhabdovirus
-RNA, bullet shape, envel, ss
glycoproteins are immunologic target
prodrome, sensory, excitement, paralytic
Characteristics of Coronavirus
+RNA, ss, enveloped
club shaped projections
common cold
Characteristics of Calcivirus
+RNA, ss, naked
Norwalk
Hep E
Characteristics of Calcivirus
member of calcivirus
+RNA, ss, enveloped
gastroenteritis (common cause) epidemics
Hep E is very similar
Characteristics of Arenaviruses
segmented, ss, -RNA, enveloped
chronic carrier state
Lymphocytic choriomeningitis
Lassa
Lymphocytic Chroiomeningitis Virus
Member of Arenovirus
segmented, ss, -RNA, env
transmitted by rodents
Lassa fever
member of arenovirus
segmented, +RNA, ss, env
rodent
high mortality
Characteristics of Filoviruses
-RNA, ss, enveloped
filamentous
Marburg & Ebola
Marburg
member of Filovirus
-RNA, ss, enveloped
Ebola
membere of Filovirus
-RNA, ss, enveloped
Characteristics of Reovirus
ds, seg'd RNA, naked
URI & GI
Rotavirus- diarrhea in infant
Orbivirus- Co Tick Fever
Rotavirus
member of Reovirus
ds, seg'd RNA, naked
major cause of diarrhea in infants
Characteristics of Retrovirus
diploid, ss, +RNA, enveloped
2 copies ss RNA
reverse transcriptase
Pol, Env, Gag proteins
HTLV & HIV