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32 Cards in this Set
- Front
- Back
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Different heavy chains
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Isotypes
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Have the same constant regions, with minor, but immunologic differences
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Allotypes
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Antibodies that recognize different specific epitopes
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Idiotype
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What Ig has the longest serum half-life?
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IgG
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What Ig(s) are best at complement fixation?
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M > G
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What Ig(s) are best at mast cell/basophil degranulation?
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IgE
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What Ig(s) are best at bacterial lysis?
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M > G=A
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What Ig(s) are best at antiviral activity?
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A > G=M
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What Ig(s) are best at toxing neutralization?
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G=A
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What Ig is found in the gamma region?
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G
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What Ig is found in the Beta region?
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M
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On what cell is IgM expressed?
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naive B cell
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What Ig is most important for memory response?
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IgM
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Elevated leves of IgM indicate what?
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recent infection or other exposure to antigen
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What Ig is best at causing agglutination and precipitation of antigens?
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IgM
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What Ig is expressed on the surface of B cells where it serves the role of antigen recognition?
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IgD
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What is the predominatnt antibody synthesized during a secondary immune response (anamnestic response)?
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IgG
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What subclass of IgG is the most rigid and best at complement binding?
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IgG3
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What subclass of IgG has the shortest half life?
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IgG3
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What Ig can mediate hemolytic disease of the newborn?
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IgG
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What Ig is used to protect immunocompromised?
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IgG
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What Ig can be used as blocking antibody to block TNF production (RA)?
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IgG
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What Ig is used as a blocking antibody to block allergens?
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IgG
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What Ig is present in interstitial fluid, i.e. deep lungs?
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IgG
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What Ig is predominant in bodily secretions?
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IgA
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When is IgA dimeric?
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in bodily secretions
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Which Igs have a J chain?
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A and M
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Larger peptide of IgA remaining after the Poly-Ig receptor is cleaved
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Secretory component
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Protects IgA from enzymatic degradation
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Secretory component
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Present in very high levels in colostrum and breast milk
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IgA
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Combats pulmonary fungal infections
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IgE
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Plays an important role in asthma
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IgE
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