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33 Cards in this Set
- Front
- Back
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These mature, primary APCs are always ready to rock
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Dendritic cells
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This APC constitutively expresses MHC II but must be activated before expressing co-stim. molecules
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B-cells
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What co-stimulatory molecule is used by B-cells to present antigens via MHC II?
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B7
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WTF is a plasmacytoid dendritic cell?
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Its a type of Dendritic Cell that secretes IL-10 and IFN-a
(as opposed to all the other flavors of DCs that secrete IL-12) |
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What two ptns play a critical role in shuttling endogenous antigens to the MHC I complex?
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1. Ubiquitin
(auger mechanism; forces normal ptns through enz.) 2. TAP (transporter assoc peptide) |
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T/F: The Endocytic Pathway requires intracellular ptn synthesis of the endogenous antigen.
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FALSE! (That's the cytosolic pathway, the one with TAP/ubiqutin) The Endocytic pathway requires EATING of Ag.
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Name three sources of mis-folded ptns:
1. 2. 3. |
1. Viral endogenous ptn
2. Bacterial endogenous ptn 3. DRiPs (defective ribosomal products) |
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Why would an immunoproteosome show a bias towards cleaving ptns AFTER hydrophobic AAs and avoids cleaving ptns after acidic AAs?
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Because (non-acidic) HYDROPHOBIC AAs make for better presenting peptides damnit!
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What unique peptide chain is assoc. MHC Class I?
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Calnexin
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What "stunt double" or chaperone ptn is critical to MHC Class I?
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ß-microglobulin
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These mature, primary APCs are always ready to rock
|
Dendritic cells
|
|
|
This APC constitutively expresses MHC II but must be activated before expressing co-stim. molecules
|
B-cells
|
|
|
What co-stimulatory molecule is used by B-cells to present antigens via MHC II?
|
B7
|
|
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WTF is a plasmacytoid dendritic cell?
|
Its a type of Dendritic Cell that secretes IL-10 and IFN-a
(as opposed to all the other flavors of DCs that secrete IL-12) |
|
|
What two ptns play a critical role in shuttling endogenous antigens to the MHC I complex?
|
1. Ubiquitin
(auger mechanism; forces normal ptns through enz.) 2. TAP (transporter assoc peptide) |
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T/F: The Endocytic Pathway requires intracellular ptn synthesis of the endogenous antigen.
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FALSE! (That's the cytosolic pathway, the one with TAP/ubiqutin) The Endocytic pathway requires EATING of Ag.
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Name three sources of mis-folded ptns:
1. 2. 3. |
1. Viral endogenous ptn
2. Bacterial endogenous ptn 3. DRiPs (defective ribosomal products) |
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Why would an immunoproteosome show a bias towards cleaving ptns AFTER hydrophobic AAs and avoids cleaving ptns after acidic AAs?
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Because (non-acidic) HYDROPHOBIC AAs make for better presenting peptides damnit!
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What "stunt double" or chaperone ptn is critical to MHC Class I?
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calnexin
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What unique ptn is ultimately required for functional MHC Class I presentation?
(Hint: it replaces the "stunt double") |
ß2-microglobulin
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Immunoresponsive cells that are infected by a virus will always make _______.
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IFN-g
IFN-b IFN-a |
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Immunoresponsive cells that are infected by a virus will always make _______.
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IFN-g
IFN-b IFN-a |
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What is the result of IFN production d.t. viral infection?
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1. Immunoproteosome induced by IFN
2. Increase in peptide/TAP associations 3. Increase in viral peptide presentation! (Bonus Pts: IFN also tunes up ____ cells) |
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What is the result of IFN production d.t. viral infection?
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1. Immunoproteosome induced by IFN
2. Increase in peptide/TAP associations 3. Increase in viral peptide presentation! (Bonus Pts: IFN also tunes up ____ cells) |
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NK cells are the default virus hunters because infected cells do what to try to hide from CD8+ cells?
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Virus infected cells decrease the levels of MHC I expression. (trying to hide from CD8+ cells)
The decreased MHC I makes it more likely trigger happy NK cells will nuke infected cells |
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NK cells are the default virus hunters because infected cells do what to try to hide from CD8+ cells?
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Virus infected cells decrease the levels of MHC I expression. (trying to hide from CD8+ cells)
The decreased MHC I makes it more likely trigger happy NK cells will nuke infected cells |
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What are some of the results of TAP deficiency?
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1. Overactive NK cells
2. Cannot defend against bacteria LEADS TO: Necrotizing Granulomatous Lesions on skin of face/limbs |
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What are some of the results of TAP deficiency?
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1. Overactive NK cells
2. Cannot defend against bacteria LEADS TO: Necrotizing Granulomatous Lesions on skin of face/limbs |
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Three word description of MHC Class II presention?
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Acidic Phagosome Fusion
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Three word description of MHC Class II presention?
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Acidic Phagosome Fusion
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What are the 3 functions of "invariant chain" in MHC II production?
1. 2. 3. |
1. Assists in folding å/ß chains
2. Binds to peptide presenting site on MHC II 3. Assists in transport of MHC II trimers via cytoplasmic tail |
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This "non-classical MHC II molecule" mediates the exchange of CLIP (placeholder) for actual antigen on MHC ClassII: _________
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HLA-DM
(HLA-DO in B-cells) |
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What weird T-cell can present antigen?
What do they present? (hint: think about it's ancestral use) |
gamma/delta T-cells
They present Mycolic acid & glycolipids. DAMN USEFUL FOR FIGHTING MYCOBACTERIUM |
