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12 Cards in this Set
- Front
- Back
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Nitroglycerin?
MOA, Use |
NO=> activates K+ channels=>membrane hyperpolarisation=>reduces [Ca], also increases cGMP which causes inhibition of Ca channels and increases MLC phosphotase these all lead to vasorelaxation=>reduces preload and afetrload (reducing O2 demand) and increases O2 supply
Use - Varient and stable angina |
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Isosorbide Dinitrate?
MOA, Use |
NO=> activates K+ channels=>membrane hyperpolarisation=>reduces [Ca], also increases cGMP which causes inhibition of Ca channels and increases MLC phosphotase these all lead to vasorelaxation=>reduces preload and afetrload (reducing O2 demand) and increases O2 supply
Use - Varient and stable angina |
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Sodium Nitroprusside?
MOA, Use |
NO=> activates K+ channels=>membrane hyperpolarisation=>reduces [Ca], also increases cGMP which causes inhibition of Ca channels and increases MLC phosphotase these all lead to vasorelaxation=>reduces preload and afetrload (reducing O2 demand) and increases O2 supply
Use - Varient and stable angina |
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Atenolol?
MOA, Use |
beta1 blocker
use - stable angina |
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Acebutolol?
MOA, Use |
beta1 blocker
use - stable angina |
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Pindolol?
MOA, Use |
beta1 blocker
use - stable angina |
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Propranolol?
MOA, Use |
beta1 and beta2 blocker
use - stable angina |
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Ivabradine?
MOA, Use, Side effects, Contra |
MOA - inhibits If current in SA node reducing HR
Use - stable angina for patients with normal sinus rhythms when beta blockers are contraindicated side effects - blurred vision, bradycardia, AV block, arrythmias Contra - Ca channel blockers |
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MOA of beta blockers treating angina?
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Block beta1 receptors reducing HR and force reducing O2 demand and a reduced HR means and increased distolic time so increased O2 supply
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Cause of stable angina?
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coronary artheroma, mismatch between O2 demand and O2 supply
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Cause of Varient Angina?
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coronary spasm
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Cause of unstable angina?
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transient platelet aggregation
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