Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
42 Cards in this Set
- Front
- Back
|
pyrogen
|
IL-1
|
|
|
stimulates T cells
|
IL-2
|
|
|
stimulates bone marrow
|
IL-3
|
|
|
stimulates IgE and IgG production
|
IL-4
|
|
|
stimulates IgA production
|
IL-5
|
|
|
neutrophils are recruited by
|
IL-8
(from macs) |
|
|
induces differentiation of t-cells into Th1 cells
|
IL-12
(from macs and B-cells) |
|
|
activates NK cells
|
IL-12
(from macs and B-cells) |
|
|
endogenous pyrogen that casues and stimulates fever
|
IL-6
|
|
|
mediates septic shock
|
TNF-alpha
|
|
|
activates the endothelium
|
TNF-alpha
(macs) |
|
|
causes leukocyte recruitment and vascular leak
|
TNF-alpha
(macs) |
|
|
supposts the growth and differentiation of bone marrow cells (functions like GM-CSF)
|
IL-3
(from t-cells) |
|
|
stimulates growth of helper and cytotoxic t-cells
|
IL-2
(Th1 cells) |
|
|
activates macrophages and Th1 cells
|
interferon gamma
(from Th1 cells) |
|
|
supresses Th2 cells
|
interferon gamma
(from Th1 cells) |
|
|
this interleukin has antiviral and antitumor properties
|
interferon gamma
(from Th1 cells) |
|
|
induces differentiation into Th2 cells
|
IL-4
(from Th2 cells) |
|
|
promotes growth of B cells
|
IL-4
(from Th2 cells) |
|
|
enhances class switching to IgE and IgG
|
IL-4
(from Th2 cells) |
|
|
promotes differentiation of B-cells
|
IL-5
(Th2 cells) |
|
|
enhances class swithcing to IgA
|
IL-5
(Th2 cells) |
|
|
stimulates gowth and differentiation of eosinophils
|
IL-5
(Th2 cells) |
|
|
modulates inflammatory response (inhibits the actions of T cells and Th1
|
IL-10
(Th2 cells) |
|
|
activates Th2 cells
|
IL-10
(Th2 cells) |
|
|
crosses placenta
|
IgG
|
|
|
mucousal surface protector
|
IgA
|
|
|
found in breast milk
|
IgA
|
|
|
found in secretions (tears, saliva, mucus)
|
IgA
|
|
|
monomer on B cell or pentamer in blood (trapping free antigens like a net/web)
|
IgM
|
|
|
binds mast cells and basophils and when exposed to allergen
|
IgE
|
|
|
mediates histimine/ type 1 hypersensitivity
|
IgE
|
|
|
unclear what this Ig does
|
IgD
|
|
|
helper Th1 cells do what to influence the immune response
|
refugulate cell mediated response
secrete Th1 cytokines (IL-2 and IFN gamma activate macrophages and CD8+t-cells inhibited by IL-10 |
|
|
helper Th1 cells do what to influence the immune response
|
regulate humoral response
secrestes Th2 cytokines: IL-4/5/10 hels B cells make ABs (IgE>IgG) inhibited by IFN gamma |
|
|
compliment protein responsible for anaphylaxis in that it stimulates mast cells and basophils to degranulate and increase His
|
C3a
|
|
|
compliment protein responsible for PMN chemotacis
|
C5a
(and IL-8 and Leukotriene B4) |
|
|
compliment protein responsible for forming the MAC
|
C5b and C 6,7,8,9
|
|
|
angioedema (from increased bradykinin) results from a deficiency in which complement associated protein
|
C1 esterase inhibitor deficiency
(do not give ACE inhibitors) |
|
|
severe recurrent pyogenic infections and URI results from a deficiency in which complement associated protein
|
C3 deficiency
especially strep pneumo and H.flu infections |
|
|
increased suceptibility to both neissieria bugs results from a deficiency in which complement associated protein
|
any of the MAC proteins (C5b and C 6,7,8,9)
|
|
|
Paroxysmal nocturnal hemolysis (presents with brown urine in the morning) and is a result of transient hypoxemia in the night
|
a lack of GPI, wich holds DAF and MIRL... this innactivates complement and prevents harm of RBS... without GPI you see increased transient hemolysis
...must diagnose with a HAMs test |
