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9 Cards in this Set
- Front
- Back
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Describe some properties of Carbapenems.
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Broad spectrum of beta-lactams
Good for both G+/G- Anaerobes |
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When do you reserve Carbapenems for?
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Infections that are resistant to PCNs/cephalosporins
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What are 4 Carbapenems and their route of administration?
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1. Imipenem - IV/IM
2. Meropenem (Merrem IV) - IV 3. Ertapenem (Invanz) - Once a day dosing 4. Doripenem (Doribax) - Injection **IMED |
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Why do you give Imipenem with Cilastatin?
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Cilastatin inhibits dehydropeptidase (not a beta-lactamase) in the kidney's proximal tubules --> Increase level of impinemem so that it can work against UTIs
Also prevents generation of nephrotoxic metabolite of imipenem |
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Does Imipenem resist beta-lactamase?
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Yes
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What are some side effects of Imipenem
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Nausea
Vomiting Increased risk of C. difficile infection (compared to other Carbapenems) Seizures (1.5%) |
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What are Doripenem used for?
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Complicated intra-abdominal infections
UTIs |
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What bacteria is extremely resistant to Carbapenem? Where are they usually found?
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Carbapenem-resistant Klebsiella pneumonia (CRKP)
Emerges in long-term care facilities, nursing homes, elderly |
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What is the Rx interaction for Carbapenems?
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Decreased levels of valproic acid --> Increased risk for seizures
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