Id: Virusses

Front 1

Influenza: Klinisch: normal

Back 1

Typical acute Influenza syndrome:
* incubation: 2 days
* sudden onset
* fever, myalgia, headache and occ. shaking chills
* dry, non productive cough
* start recovery 1 week after onset.

Front 2

Influenza: Klinisch: Worse

Back 2

* Caveat: secondary bacterial (super)infection. (H.influenza, S Pneumoniae, Staph Aureus)
* Rapid development: pneumonia
* Children: 2-12 days post-onset: Reye's syndrome: fatty infiltration of the liver and cerebral edema.

Front 3

Influenza: Virulentiefactoren:

Back 3

* (b) antigene shift
* (c) antigene variatie
* (a) adhesie-glycoproteinen (H en N)
* (i) Enzymen die weefsel afbreken

Front 4

Influenza: Diagnostiek:

Back 4

(j) Neusuitstrijk of (h) keeluitstrijk en (h) kweek viraal
of
(d) PCR

Front 5

Influenza: Treatment

Back 5

Symptomatic care and Supportive therapy
Antiviral tp: rimantadine etc. not effective

Front 6

Influenza: Epid

Back 6

(h) contact met druppels luchtwegsecreet
(m) inademen van kleine druppels luchtwegsecreet

Front 7

Influenza: prevention

Back 7

(i) handhygiene
(n) neusmondmasker FFP2
(t) vaccinatie

Front 8

RSV: Klinisch

Back 8

* vnl kleine kinderen
* croup, bronchitis, bronchiolitis or pneumonia
* acute phase: cough, wheezing en respiratory distress 1-3 weeks

Front 9

RSV: Epid

Back 9

INFANTS
mortality: 0,5-1%
if immcomp: 15%

Front 10

RSV: virulentiefactoren

Back 10

* (a) adhesie glycoproteinen
* (k) syncytiumvorming

Front 11

RSV: Diagnostiek

Back 11

* (c) antigeentest viraal
* (d) PCR

Front 12

RSV: Treatment & Prevention

Back 12

* supportive treatment

Front 13

Polio: Klinisch

Back 13

* Incubation 7-14 days (4-35)
Three types:
* Abortive poliomyelitis: nonspecific febrile illness 2-3 days
* Abortive poliomyelitis + Aseptic meningitis (nonparalytic poliomyelitis): meningeal irritation: stiff neck, pain, stiffness in the back + abortive poliomyelitis
*paralytic poliomyelitis: <2% of infection: meningeal irritation, asymmetric flaccid paralysis with no sign. sensory loss.

revocery of function up to six months. Any longer = permanent paralysis

Front 14

Poliio: Virulentie

Back 14

(g) endocytose (viropexis)
(c) antigene variatie

Front 15

Polio: Diagnose

Back 15

(h) keeluitstrijk
(f) feces
(i) liquor cerebrospinalis
(l) pleuravocht
op
(d) PCR

Front 16

Polio: Treatment

Back 16

No fucking treatment

Front 17

Polio: Epid

Back 17

(l) humaan feco-oraal contact
(j) contact met zoetwater (riool)
(v) vliegenbeet (verspreiding)
* resistant to acid, detergents and many disinfectants

Front 18

Polio: Preventie

Back 18

(a) adequate verhitting van voedsel
(t) vaccines
(p) riolering
persoonlijke hygiene
(i) handhygiene
(w) waterzuivering

Front 19

HBV: Klinisch

Back 19

* incubation 60-90 (30-180)
* onset: fatigue, loss of appetite, nausea and pain, fullness in liver region
* pain and swelling joints
* liver involvement: cholestasis, darekening of urine and jaundice.
chronic: cirrhosis, liver failure and hepatocellular carcinoma

Front 20

HBV: Virulentiefactoren

Back 20

(a) adhesie (HBsAg)
(b) vermogen om gastheercellen te doden

Front 21

HBV: Diagnostiek

Back 21

(c) bloed
in
(c) antigeen test viraal
(q) serologie (Anti-HB)

Front 22

HBV: Treatment

Back 22

supportive and treatment complications

(o) Lamivudine

Front 23

HBV: Epid

Back 23

(b) bloedtransfusie
(r) prikverwonding
(s) sexueel contact
(u) verticale transmissie

Front 24

HBV: Preventie

Back 24

(b) antimicrob profylaxe
(s) sterillisatie
(r) screening bloedprodukten

Front 25

HSV1: Manifestation

Back 25

* usually above the waist
* vesicular lesions become pustular and then ulcerate:
* multiple ulcers
*gingivostomatitis: fever, ulcers @ buccal mucosa, tongue, gums, pharynx.

Front 26

HSV2: Manifestation

Back 26

*Primary Genital Herpes Infection:
Ulcers genital region
*Recurrent Genital Herpes Infection:
prodromal paresthesias and shorter duration

Front 27

HSV: Virulence

Back 27

* antigenic variation
* adhesion proteins
* lytic infection
* latency

Front 28

HSV: Diagnosis

Back 28

*Infected lesions or Secretions
*cervix/urethra
on
*Viral culture
*Antigen detection
*PCR

Front 29

HSV: Treatment

Back 29

Acyclovir

Front 30

HSV: Epid

Back 30

Sexual activity

Front 31

HSV: Prevention

Back 31

Safe sex

Front 32

VZV: Manifestations

Back 32

* chickenpox (varicella)
* shingles (zoster)

caveat immcomp: encephalitis, pneumonia, hepatitis and nephritis.

Front 33

VZV: Virulence

Back 33

* latency

Front 34

VZV: Diagnosis

Back 34

Lesions
to
*antigen detection
* PCR on CSF

Front 35

VZV: Treatment

Back 35

acyclovir

Front 36

VZV: Epid

Back 36

* respiratory droplets
* direct contact lesions

Front 37

VZV: Prevention

Back 37

*passive immunization
*vaccination
*isolation

Front 38

CMV: Manifestations

Back 38

birth CMV: sensory nerve hearing loss, psychomotor mental retardation. Congenital: hepatosplenomegaly, jaundice, anemia, thrombocytopenia, microcephaly etc.

Normal: Asymptomatic: mononucleosis-like symptom

Immcomp: lung, visceral and eye infections.

Front 39

CMV: Virulence

Back 39

* latency
* direct tissue damage
* immune mediated disease: lung pathology

Front 40

CMV: Diagnosis

Back 40

* Owl's eye inclusion
* PCR
* antigen detection
* serology

Front 41

CMV: Therapy

Back 41

Ganciclovir

Front 42

CMV: epid

Back 42

* Vertical transmission
* Sexual contact
* saliva, semen, cervical secretions, urine.

*young children/adults

Front 43

CMV: prevention

Back 43

* bloodscreen

Front 44

EBV: manifestations

Back 44

* Infectious Mononucleosis: fever, malaise, pharyngitis, tender lymphadenitis and splenomegaly
* Lymphoproliferative Syndrome: @immcomp: fever, lymphadenopathy and hepatosplenomegaly
* Burkitt Lymphoma:
* Nasopharyngeal Carcinoma

Front 45

EBV: Virulence3

Back 45

infects: epithelial and b cells

Front 46

EBV: Diagnosis

Back 46

* serologie

Front 47

EBV: Therapy

Back 47

* acyclovir

Front 48

EBV: epid

Back 48

Fucking veel mensen heeft dit virus! Meestal geen symptomen

Front 49

EBV: preventie

Back 49

*bloedtransfusie: bloed screening

Front 50

HIV: Manifestations

Back 50

* caveat secondary infections

Front 51

HIV: Virulence3

Back 51

* Enzymen die RNA/mRna productie verlagen
* latency

Front 52

HIV: Diagnosis

Back 52

* serologie
* PCR

Front 53

HIV: epid

Back 53

* sexual
* vertical
* bloodneedles

Front 54

CA: Manifestations

Back 54

* Thrush oral lesions
* white cheesy plaque
* vaginitis
* esophagitis

*UTI
*Endopthalmitis

Front 55

CA: virulence3

Back 55

* Hyphae
* Enzymen die weefsel afbreken.

Front 56

CA: Diagnosis

Back 56

lesions on KOH or Gram
if pulm, then BAL

Front 57

CA: Treatment

Back 57

Amphotericin B
Fluconazole

Front 58

CA: Epid

Back 58

* normal flora

Front 59

AF: manifestations

Back 59

* usually in immcomp symptoms.
* allergic disease: pulmonary infiltrates and eosinophilia.
Cave: immcomp pneumonia

Front 60

AF: virulence

Back 60

* hyphae
* adherence
* extracellular enzymes
* toxins?

Front 61

AF: diagnosis

Back 61

Direct aspirate needed: BAL, biopt.
on
Kweek schimmels

Front 62

AF: tp

Back 62

Amphotericin B
Azoles

Front 63

AF: epid

Back 63

* nature
* inhalation spores

Front 64

PV/PF: manifestation

Back 64

* Malaria: fever, headache, sweating, malaise, Anemia: in episodes
*vasodilatation: hypotension

Front 65

PV/PF:: virulence

Back 65

vermogen gastheercell te doden
Intracellular

Front 66

PV/PF:: diagnosis

Back 66

bloed: microscopie, eieren: larven: parasieten

Front 67

PV/PF:: therapy

Back 67

chloroquine
arthemeter
primaquine

Front 68

PV/PF: epid

Back 68

* muggenbeet

Front 69

PV/PF: prevention

Back 69

* kleding
* muggenbeet bescherming
* vectorbestrijding
*antimicrob proxylaxe
*vaccinatie

Front 70

ToxoG: manifestation

Back 70

* congenital toxoplasmosis: gewoon drama
*normal host: asymptomatic localized lymphadenopathy
* fever, sore throat, rash, hepatosplenomegaly.
caveat: pneumonitis, myocarditis, meningoencephalitis
* immcomp: serious fatal disease: necrotizing pneumonitis, myocarditis and encephalitis.

Front 71

ToxoG: virulence

Back 71

* intracellular

Front 72

ToxoG.: diagnosis1

Back 72

* serology

Front 73

ToxoG.: tp

Back 73

???

Front 74

ToxoG.: epid

Back 74

* vertical
* uncooked meat

Front 75

ToxoG.: prevention

Back 75

cook meat
cat feces

Front 76

E Histo: Manifestation

Back 76

Diarree, flatulence and cramping abdominal pain. mucus blood.
Hepatic abscess

Front 77

E Histo: Virulence

Back 77

* endocytosis
* enzymes weefselschade

Front 78

E Histo: Diagnosis

Back 78

Stool and microscopy
Antigeen test protozoa

Front 79

E Histo: Tp

Back 79

mebendazole

Front 80

E Histo: epid

Back 80

warme landen
* feco-oraal
*

Front 81

E Histo: Prevention

Back 81

riolering

Front 82

Giardia: manifestation

Back 82

Intestinal infection: greasy diarrhea 4 weeks

Front 83

Giardia: virulence

Back 83

Iga Defi

Front 84

Giardia: diagnosis

Back 84

stool
antigen test

Front 85

Giardia: tp

Back 85

azoles

Front 86

Giardia: epid

Back 86

water
dieren
fecooraal

Front 87

Giardia: prev

Back 87

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