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25 Cards in this Set
- Front
- Back
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Neutropenia is defined as neutrophil cound below what?
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500 mm3
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Reduced neutrophil count is commonly caused by what?
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chemotherapy
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Cell-mediated immune deficiencies are associated with what?
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-corticosteroids
-organ transplan |
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Mixed defects are seen chiefly in bone marrow transplant patients who what?
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-are neutropenic in early stages
-have depressed cell mediated immunity |
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The risk of neutropenia and mucositis is closely related to what?
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-neutropenia
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Infecting organisms in neutropenia and mucositis are commonly found where?
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-mouth
-GI tract -skin |
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What are the common bacteria that affect in Neutrophenia and Mucositis?
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-S. epidermidis
-S. aureus -S. Viridans -Enterococci -Pseudomonas |
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What common fungi are associated with neutropenia and mucositis?
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-candida
-aspergillus |
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Defective cell-mediated immunity patients have a higher risk of what bacterial infections?
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-mycobacterium
-Listeria -Nocardia -Salmonella |
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What fungal infection is most common in defective cell-mediated immunity patients?
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Cryptococcus
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What are some other causes of fungal infections in the defective cell-mediated immunity patients?
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-Aspergillus
-Fasarium -Mucor -Rhizopus |
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What virus is most commonly reactivated in immunocompromized hosts?
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CMV
EBV is less common |
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What other pathogens can be seen in defective cell-mediated immunity patients?
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-Pneumocystis
-Toxoplasma -Strongyloides |
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Tell me about the Phase I of immunosuppression following transplant.
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-0-30 days and have neutropenia
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Tell me about Phase II of immunosuppression following transplant.
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-30-100 days: Primarily depressed cell-mediated immunity and graft vs. host disease
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Tell me about Phase II of immunosuppression following transplant.
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-beyond 100 days: depressed cell-mediated and humoral immunity, chronic graft vs host disease
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What antibiotics can you use for monotherapy in the neutrophenic patient?
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-cefepime
-imipenem -bactrim |
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What dual therapy can you use in the neutrophenic patient?
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-beta-lactum plus an aminoglycoside or FQ
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What antibiotic should you use add for either a catheter-related infection or MRSA in the neutrophenic patient?
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Vanco
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After how many hours do you reassess in the neutrophenic patient?
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96 hours
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If fevers lasts longer than 96 hours in a neutropenic patient on antibiotics, what should you do?
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add anti-fungal therapy
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In cell-mediated immunity, are empiric antibiotics recommended?
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NO
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If you have CNS symptoms in depressed cell-mediated patients, what should you consider?
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-Cryptococcus
-Listeria |
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If you have an infected central line in a immunodepressed patient, what should you do?
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start empiric antibiotics
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Is a low-grade fever in a patient on corticosteriods something to be concerned with?
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YES
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