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45 Cards in this Set
- Front
- Back
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category A diseases of bioterrorism?
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antrax (bacillus anthracis)
smallpox (variola virus) plague (yersinia pestis) tularemia (francisella tularensis) botulism (botulinum toxin) viral hemorrhagic fever |
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3 disease forms of anthrax?
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cutaneous
GI inhalational |
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2 toxins of anthrax?
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edema toxin (cause pleural effusion)
lethal toxin |
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prodromal phase of anthrax is influenza like.. however what is different?
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almost no rhinorrhea
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Dx of anthrax?
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blood culture
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Tx of anthrax?
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ciprofloxaxin or doxycycline plus 1-2 others
cephalosporin not effective maybe vaccine supportive care |
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does person-person transmission occur in anthrax?
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no
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person-person transmission in smallpox?
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yes. airborne possible
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2 stages of small pox
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prodromal stage (severe flu like, not contagious)
eruptive stage (rash. contagious) |
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characteristic of smallpox rash?
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oral ulcer -> maculopapular -> vesiculopustular
centrifugal pattern all same stage |
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characteristics of chickenpox rash?
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asynchronous development
centripetal spares palm/soles |
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Tx of smallpox?
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supportive, airborne, droplet isolation
post exposure prophylaxis - vaccine primary prophylaxis - vaccine |
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rat, prairie dog reservoir, cats
flea vector. which bioterrorism? |
plague - yersinia pestis
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person-person possible in plague?
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pneumonic form only
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3 manifestation types in plague?
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bubonic
pneumonic septicemic |
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tx of plague
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aminoglycoside - streptomycin, gentamicin
doxycycline (higher relapse rate) ciprofloxacin works pretty well cephalosporins ineffective |
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"rabbit fever"
host small mammals |
tularemia (francisella tularensis)
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vector of tularemia?
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ticks, deer flies
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characteristics of tularemia?
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**bradycardia with high fever
low back myalgia pulse-temp dissociation ulcer at inoculation proximal lymphadenopathy |
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Dx of tularemia?
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no good Dx
culture has poor sensitivity/dangerous serology - 2 week delay |
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tx of tularemia?
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aminoglycosides - streptomycin, gentamicin
doxycycline ciprofloxacin cephalosporin ineffective |
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person to person in tularemia?
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no
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generalized zoonosis Tx?
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doxycycline
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what do you do with animal bite wounds?
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assess rabies risk
irrigate but not suture! assess infection risk. |
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worse in terms of giving disease. cats of dogs?
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cats
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normal mouth flora of animal?
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eikenella corrodens
staph aureus pasteurella multocida |
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Tx of animal bite?
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augmentin (amoxicillin + clavulanate)
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animal reservoir is bats, skunks, raccoons, foxes
100% fatality retrograde axonal spread |
rabies
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what histopathological feature does rabies have?
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negri bodies
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Dx of rabies
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clinical is main..
PCR saliva, neck biopsy for IFA, serum/CSF for Ab |
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post exposure Tx for rabies
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wound care
vaccine immunoglobulin experimental: ribavirin, IFN alpha, amantadine |
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cat scratch disease
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bartonellosis (bartonella henselae)
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features of bartonellosis?
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relatively mild
vesicle/papule/pustule painful lymphadenitis fever encephalopathy |
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Dx of bartonellosis?
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PCR, serology
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Tx of bartonellosis?
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azithromycin (effect not well known)
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direct/produc contact
agent is coxiella burnetti flu like illness atypical pneumonia endocarditis, osteomyelitis |
Q fever
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Tx of Q fever?
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acute - doxy
chronic - doxy + rifampin |
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Dx of Q fever?
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serology
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contract from delivery of cow..
ingestion of unpasteurized milk wide variety of presentation -MSK, GI, GU, cardio, neuro, skin |
brucellosis
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Dx of brucellosis?
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culture, serology
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agent of brucellosis?
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brucella melitensis, B. abortus
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Tx of brucellosis?
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doxy + aminoglycoside or rifampin
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very common in birds
very infectious transmission via bird contact/presence pneumonia - lower lobe consolidation |
psittacosis (chlamydia psittaci)
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Dx of psittacosis
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serology, culture
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Tx of psittacosis
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doxy
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