Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/44

Click to flip

44 Cards in this Set

  • Front
  • Back
ex of decreased production of WBC
1.aplastic anemia (prob w/production or diff of stem cell)
2.Vit B12/folate def (req for DNA syn)
3.myelodysplastic syndrome (myeloid precursor (after stem cell) doesn't work)
4.BM invasion by cancer
ex of decreased survival of WBC
Felty's syndrome (neutropenia w/patients with RA)
ex of redistribution of WBC
1.splenomegaly
2.acute infxn in whicih most WBC migrate to that area
pathophys of leukopenia
1.decreased prod of WBC
2.dec survival of WBC
3.redistribution
in a pt w/anbl WBC count, what should you do after analyzing the CBC
YOU MUST REVIEW THE PERIPHERAL SMEAR YOURSELF
important component of tx CLL
(CLL is incurable), but important is the early Dx and Tx of INFXNS since pt prone to develpp serious infxn complications due to hypogammaglobulinemia
how cure CLL?
incurable
how cure CML?
BM transplant
all stages of granulocyte development in peripheral blood suggests what dz?
CML
LUQ pain or early satiety suggests what dz?
CML (Sx due to splenomegaly)
t(9;22) in what dz
CML
clinical course of CML
1. "chronic phase"--3 to 4 yr
2. "accelerated phase"-systemic sx, increasing WBC despite Tx, incr basophilia nad eosinophilia, incr proportion of blasts and immature cells in BM and circulation
3. "blast crisis"-looks like acute leukemia but response to Tx is worse than acute leukemia
Tx CML
1.BM=cure
2.Interferon+cytarabine (ara-c): older pts or pt w/o donors
3.hydroxyurea-only controls WBC count and does not delay onset of blastt crisis
4.imatinib mesylate (Gleevec)- inhibits bcr-abl tyrosine kinase, the constitutive abnl gene product of philadelphia chrom
splenomegaly,
thrombocytosis
decreased LAP
CML
sx of CML
splenomegaly
thrombocytosis
decreased LAP
Tx for olderr pt w/CML or pt w/o suitable BM donors
interferon + cytarabine (ara-c)
Tx: CML but only controls WBC count and does not delay onset of blast crisis
hydroxyurea
MOA of imatinib mesylate
AKA Gleevec,
inhibits bcr-abl tyrosine kinase (the abnl gene product of philadelphia chronosome)
leukomoid rxn
extremely high WBC count that mimics CML
-LOTS mature neutrophils (<50,000/mm3) in band and earlier forms
-increased platelets but <60,000
LAP nl or dec
Sx of acute leukemia
bleeding from mucosal surfaces;
range from minimal to pallow, petechiae, retinal hemorrhage
Sx of AML
gingival hypertrophy
gingival hypertrophy
AML
Sx of ALL
hepatomegaly and lymphadenopathy
which leukemia has hepatomegaly and lymphadenopathy
AML
pancytopenia
acute leukemias (AML or ALL)
leukostasis
clumping of WBC's together, seen in acute leukemias
-can manifest as mental changes, CN palsies, dyspnea/resp failure (d/t thrombi in circulation)
mental changes, CN palsies, dyspnea/resp failure
acute leuk (AML or ALL)
what type of chemo is
aggresive chemo to clear BM of blasts and restore nl hematopoiesis
induction chemo
what type of chemo is further chemo to prevent recurrenece even after complete remission (<5% blasts in BM)
consolidation chemo
what type of chemo is
low doses of chemo by mouth for prolonged time (1-2 yrs), for ALL
maintenance chemo
what type of chemo is
radiotherapy of CNS since it is a sanctuary of this type of chemo?
prophylactic chemo, for ALL
after pts relapse after chemo, what is the only curative Tx?
BM transplat
can Hodgkin's Lymphomas be cured?
yes, most ppl cured
cervical, supraclavicular, and mediastinal lymphadenopathy that typically spreads to contiguous nodes
Hodgkin's lymphoma
"waxing and waning" lymphadenopahty
hodgkin's lymphoma
Reed Sternberg cell
Hodgkins
what is most imp determinant of Tx and outcome of hodgkins
disease stage
which leukemia presents with LUQ pain or early satiety
CML
leukocytosis w/all stages of granulocayte development
CML
decreased LAP
CML
Gleevec
Tx for CML; t(9;22) (Phil chrom)
inhibits bcr-abl tyrosine kinase (the abnl gene produced by philadelphia chrom)
hypogammaglobulinemia
CLL
leukemia assoc w/high risk of infxn
CLL
leukemia w/hypogammaglobulinemia
CLL (makes sense b/c CLL has lots of NAIVE B cell--can't make specific IgG)