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125 Cards in this Set
- Front
- Back
Routes of Admin
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Enteral (via GI / alimentary Tract--Oral; Sublingual, Rectal) or Parenteral (NOT via GI tract--Inhalation; IV; IM; SC; Transdermal, Topical)
Routes of Admin |
|
Anxiolytics / Premed / Morning Cocktail
|
can give w / narcotic like Fentanyl, but lower dose or will see resp depression
Anxiolytics / Premed / Morning Cocktail Group 1 |
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Anxiolytics
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a drug that relieves anxiety.
An anxiolytic (antipanic or antianxiety agent) is a drug prescribed for the treatment of symptoms of anxiety. Some anxiolytics have been shown to be useful in the treatment of anxiety disorders, as have antidepressants such as the class of selective serotonin reuptake inhibitors (SSRIs). |
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Midazolam
Drug (trade name) |
(versed)
Anxiolytics / Premed / Morning Cocktail Group 1 |
|
Midazolam
Class |
Benzodiazepine
Anxiolytics / Premed / Morning Cocktail Group 1 |
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Benzodiazepine
|
a drug belonging to a group of minor tranquilizers.
Use: short-term treatment for sleeping difficulties. Benzodiazepines have varying sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, muscle relaxant and amnesic properties. These properties make benzodiazepines useful in treating anxiety, insomnia, agitation, seizures, muscle spasms, and alcohol withdrawal. Benzodiazepines vary in their elimination half-life, and are categorized as either short-, intermediate- or long-acting. Short- and intermediate-acting benzodiazepines are preferred for the treatment of insomnia; longer-acting benzodiazepines are recommended for the treatment of anxiety. |
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Midazolam
Uses |
Anxiolysis,
Sedation, Amnesia Anxiolytics / Premed / Morning Cocktail Group 1 |
|
Midazolam
[ Supplied ] |
1mg / mL
Anxiolytics / Premed / Morning Cocktail Group 1 |
|
Midazolam
Dosing--card |
1mg
(0.5-2.0) or 0.15-0.3 mg / kg Anxiolytics / Premed / Morning Cocktail Group 1 |
|
Midazolam
Dosing--Stever |
1-2.5mg
Anxiolytics / Premed / Morning Cocktail Group 1 |
|
Midazolam
Caution |
Hepatic Disease, Elderly, Synergy w / Narcotics
Anxiolytics / Premed / Morning Cocktail Group 1 |
|
Midazolam
Notes |
Onset 2-5m
Anxiolytics / Premed / Morning Cocktail Group 1 |
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Induction Drugs
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very lipid soluble, fast on, fast off, short duration (3-5m), Note Propofol / etomidate burn on injection, ketamine has Analgesic effects, and thiopental has a high pH…watch out for crystallization of drug if added w / acidic drug…instead, push thiopental, flush through into body w / IV fluid, then do acidic drug
Induction Drugs Group 2 |
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Propofol
Drug (trade name) |
(Diprivan)
Induction Drugs Group 2 |
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Propofol
Class |
Diisopropylphenol
Induction Drugs Group 2 |
|
Propofol
Uses |
Induction,
Sedation, MAC Induction Drugs Group 2 |
|
Propofol
[ Supplied ] |
10mg / mL
Induction Drugs Group 2 |
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Propofol
Dosing--card |
2mg / kg
(1-2.5) Induction Drugs Group 2 |
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Propofol
Dosing--Stever |
1.5-2.5mg / kg Ind; 25-100mcg / kg / min Inf.
Induction Drugs Group 2 |
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Propofol
Caution |
Bacterial growth, soy / egg allergy
Induction Drugs Group 2 |
|
Propofol
Notes |
Pain on injection, emulsion, elim via redist., ↓ PONV & BP
Induction Drugs Group 2 |
|
Sodium Thiopental
Drug (trade name) |
Sodium Thiopental
(aka: Sodium Pentothal) Induction Drugs Group 2 |
|
Sodium Thiopental
Class |
Barbiturate
Induction Drugs Group 2 |
|
Barbiturate
|
A drug with sedative and hypnotic properties belonging to a group of derivatives of barbituric acid
|
|
Sodium Thiopental
Uses |
Induction,
cerebral protection Induction Drugs Group 2 |
|
Sodium Thiopental
[ Supplied ] |
2.5%
Induction Drugs Group 2 |
|
Sodium Thiopental
Dosing--card |
4mg / kg (3-6)
Induction Drugs Group 2 |
|
Sodium Thiopental
Dosing--Stever |
3-5 mg / kg
Induction Drugs Group 2 |
|
Sodium Thiopental
Caution |
Drug Interaction (add acidic drug w / it-->Precip.); Apnea
Induction Drugs Group 2 |
|
Sodium Thiopental
Notes |
Will burn b / c high pH of 10 v. pH of blood 7.4;
Garlic Taste Induction Drugs Group 2 |
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Local Anesthetics
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Transient loss of sensory, motor, and autonomic function in a discrete portion of the body; reversible conduction of blockade of impulses along central and peripheral nerve pathways; Divided into Amides and Esters; Amides ( I b4 caine) metabolized by liver & Esters (no i b4 caine) metabolized in plasma via plasma cholinesterases, also will cause allergic Rxn in ppl allergic to PABA in sunscreen. Note that Vasoconstrictors (i.e. Epinephrine) increase duration of action of local anesthetic by limiting systemic absorption and maintaining the drug [c] at the nerve. It also decreases possibility of systemic toxicity and has little effect on onset (use 5mcg / ml or 1:200,000 Epi w / local anesthetic); Symptoms of Toxicity: Circumoral numbness (lips), Tinnitus (ringing in ears), taste pennies, lightheadedness, visual disturbances, muscular twitching, unconsciousness, convulsions, respiratory depression, cardiovascular collapse (described w / increasing levels of toxicity);PVC=premature ventricular contraction; Infiltration=using lidocaine to numb area b4 giving IV / creating wheal under skin; use nebulizer to numb airway for awake intubation; use at induction to attenuate burning on injection of induction drugs; IV regional anesthesia (IVRA) = Bier Block; Peripheral Nerve Block (PNB) = ankle or femural block;
. Local Anesthetics Group 11 |
|
Local Anesthetics
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An anesthetic that causes loss of sensation only to the area to which it is applied.
A local anesthetic is a drug that causes reversible local anesthesia and a loss of nociception. When it is used on specific nerve pathways (nerve block), effects such as analgesia (loss of pain sensation) and paralysis (loss of muscle power) can be achieved. |
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Lidocaine
Drug (trade name) |
Lidocaine
Local Anesthetics Group 11 |
|
Lidocaine
Class |
Amide
Local Anesthetics Group 11 |
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Amide
|
In chemistry, amide usually refers to organic compounds that contain the functional group consisting of an acyl group (C=O) linked to a nitrogen atom (N).
The term refers both to a class of compounds and a functional group within those compounds. The term amide also refers to deprotonated form of ammonia (NH3) or an amine, often represented as anions R2N-. |
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Lidocaine
Uses |
local anesthesia, cough, inhalation
Local Anesthetics Group 11 |
|
Lidocaine
[ Supplied ] |
0.5-5%
Local Anesthetics Group 11 |
|
Lidocaine
Dosing--card |
1mg / kg IV
Local Anesthetics Group 11 |
|
Lidocaine
Dosing--Stever |
Topical (4%); Infiltration (0.5-1%); IVRA (0.25-0.5%); PNB (1-1.5%); Epidural (1.5-2%); Spinal (1.5-5%)
Local Anesthetics Group 11 |
|
Lidocaine
Caution |
Hepatic Disease (metab. In liver)
Local Anesthetics Group 11 |
|
Lidocaine
Notes |
Hepatic Clearance
Toxic Dose: 5mg / kg alone 7 mg / kg with Epi Local Anesthetics Group 11 |
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NMB Reversal Drugs
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The Wake Up; Induction drugs long gone, turned gas off so that is gone too, need to get rid of NMBs; Anticholinesterase Drugs prevent the hydrolysis of Ach, and an increase [Ach] @ NMJ competes with ND NMBDs; clinical uses--reversal of Non-depol NMBDs; Mech. of action--enzyme inhibition, pre-synaptic effects, NMJ effects; get this increase [Ach] everywhere though, so get the BLUDS effect--attenuate by using in combination w / Anticholinergic drugs; BLUDS= bradycardia / bronchospasm, lacrimation, urination, defication, salivation; Anticholinergic Drugs used clinically most often as pre-op med, for treatment of bradycardia, for NDNMB reversal and less frequently for bronchodialation, smooth muscle relaxant, antagonist of gastric acid secretion, & to prevent N / V; work by blocking muscarinic Ach receptors activated by parasymp. NS, careful though....will cause dialation of pupils (worsens Glaucoma) and will cross placenta in pregnant woman (Cautions=Glaucoma / Parturients). (Parturient=pregnant woman)
NMB Reversal Drugs Group 9 |
|
Atropine
Drug (trade name) |
Atropine
NMB Reversal Drugs Group 9 |
|
Atropine
Class |
Anticholinergic
NMB Reversal Drugs Group 9 |
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Anticholinergic
|
An _____ agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an .
is dicyclomine. . s are administered to reduce the effects mediated by acetylcholine on acetylcholine receptors in neurons through competitive inhibition. Therefore, their effects are reversible. |
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Atropine
Uses |
Bradycardia, accompany NMB Reversal to fight BLUDS
NMB Reversal Drugs Group 9 |
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Atropine
[ Supplied ] |
0.4, 0.5, 1mg / ml
NMB Reversal Drugs Group 9 |
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Atropine
Dosing--card |
1.0mg vagolytic dose; 0.01mg / kg NMB reversal
NMB Reversal Drugs Group 9 |
|
Atropine
Dosing--Stever |
IM 0.01-0.02 mg / kg (up to 0.4-0.6 mg); Bradycardia 0.4-0.6mg (up to 3mg)
NMB Reversal Drugs Group 9 |
|
Atropine
Caution |
Glaucoma, Parturients
NMB Reversal Drugs Group 9 |
|
Atropine
Notes |
||
NMB Reversal Drugs Group 9 |
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Neuromuscular Blocking Drugs
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Paralysis / Muscle Relaxation; Facilitate tracheal intubation, improve surgical working conditions, good for mechanical ventilation of lungs, treat laryngospasm; Classified / chosen according or whether Depolarizing (mimics ACh, binds receptor @ muscle and activates receptor) or Non-depolarizing (binds @ receptor and blocks ACh), duration of action (whether long, intermediate or short acting; duration also affected by liver / kidney disease so keep that in mind), speed of onset, side effects, & pathophysiology; Act by interupting transmission of nerve impulses at NMJ of muscles; review in ppt adverse effects of SUX); Note: Int= Intubation Dose, Inf= Infusion
Neuromuscular Blocking Drugs Group 3 |
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Neuromuscular Blocking Drugs
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Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles.
This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release, or by acting postsynaptically at the acetylcholine receptor. While there are drugs that act presynaptically (such as botulin toxin and tetrodotoxin), the clinically-relevant drugs work postsynaptically. Clinically, neuromuscular block is used as an adjunct to anesthesia to induce paralysis, so that surgery, especially intra-abdominal and intra-thoracic surgeries, can be carried out with fewer complications. Because neuromuscular block may paralyze muscles required for breathing, mechanical ventilation should be available to maintain adequate respiration. Patients are still aware of pain even after full conduction block has occurred; hence, general anesthetics and / or analgesics must be given to prevent anesthesia awareness. |
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Cisatracurium
Drug (trade name) |
(Nimbex)
Neuromuscular Blocking Drugs Group 3 |
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Cisatracurium
Class |
Benzyl isoquinolinium, ND
Neuromuscular Blocking Drugs Group 3 |
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Benzyl isoquinolinium
|
Isoquinolines find many applications, including (but not limited to): anesthetics; dimethisoquin is one example.
vasodilators, a well-known example, papaverine. |
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Cisatracurium
Uses |
Paralysis
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
[ Supplied ] |
20mg vial (2mg / ml)
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
Dosing--card |
0.1mg / kg (0.1-0.15)
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
Dosing--Stever |
Int same, Inf 1-2mcg / kg / min
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
Caution |
||
Neuromuscular Blocking Drugs Group 3 |
|
Cisatracurium
Notes |
Onset: 3-5 min
Duration: 20-35 min Hoffman Elim.,not metab in liver / kidneys, use for pt w / renal disease Neuromuscular Blocking Drugs Group 3 |
|
Pancuronium
Drug (trade name) |
(Pavulon)
Neuromuscular Blocking Drugs Group 3 |
|
Pancuronium
Class |
Aminosteroid, ND
Neuromuscular Blocking Drugs Group 3 |
|
Pancuronium
Uses |
Paralysis
Neuromuscular Blocking Drugs Group 3 |
|
Pancuronium
[ Supplied ] |
1mg / mL
Neuromuscular Blocking Drugs Group 3 |
|
Pancuronium
Dosing--card |
0.1mg / kg (0.08-0.12)
Neuromuscular Blocking Drugs Group 3 |
|
Pancuronium
Dosing--Stever |
Int same, Mt 0.01mg / kg
Neuromuscular Blocking Drugs Group 3 |
|
Pancuronium
Caution |
↑ HR (tachycardia), MAP, CO; Clearance ↓ up to 50% w / renal failure
Neuromuscular Blocking Drugs Group 3 |
|
Pancuronium
Notes |
Onset: 3-5 min
Duration: 60-90 min Long duration, Hepatic / Renal Elim. Neuromuscular Blocking Drugs Group 3 |
|
Rocuronium
Drug (trade name) |
(Zemuron)
Neuromuscular Blocking Drugs Group 3 |
|
Rocuronium
Class |
Aminosteroid, ND
Neuromuscular Blocking Drugs Group 3 |
|
Aminosteroid
|
Aminosteroids are a group of drugs with a similar structure based on a steroid nucleus.
Examples are the muscle relaxants rocuronium, vecuronium and pancuronium. |
|
Rocuronium
Uses |
Paralysis, RSI
Neuromuscular Blocking Drugs Group 3 |
|
Rocuronium
[ Supplied ] |
10mg / ml
Neuromuscular Blocking Drugs Group 3 |
|
Rocuronium
Dosing--card |
0.6mg / kg (0.6-1.2)
Neuromuscular Blocking Drugs Group 3 |
|
Rocuronium
Dosing--Stever |
Int same (RSI dose), Maint 0.1mg / kg, Infusion 5-12 mcg / kg / min
Neuromuscular Blocking Drugs Group 3 |
|
Rocuronium
Caution |
Renal failure (b / c excreted via kidneys)
Neuromuscular Blocking Drugs Group 3 |
|
Rocuronium
Notes |
Onset: 1-2 min
Duration: 20-35min Neuromuscular Blocking Drugs Group 3 |
|
Succinylcholine
Drug (trade name) |
Succinylcholine (Anectine)
Neuromuscular Blocking Drugs Group 3 |
|
Succinylcholine
Class |
Depolarizing NMBD
Neuromuscular Blocking Drugs Group 3 |
|
Succinylcholine
Uses |
Intubation, Paralysis, Laryngospasm
Neuromuscular Blocking Drugs Group 3 |
|
Succinylcholine
[ Supplied ] |
20mg / ml
Neuromuscular Blocking Drugs Group 3 |
|
Succinylcholine
Dosing--card |
1mg / kg
(1-1.5) Neuromuscular Blocking Drugs Group 3 |
|
Succinylcholine
Dosing--Stever |
Int same; Laryngospasm 0.1mg / kg IV
Neuromuscular Blocking Drugs Group 3 |
|
Succinylcholine
Caution |
Bradycardia, Hyperalkemia, open globe injury (increases cerebral, intraabdominal and intraoccular pressure)
Neuromuscular Blocking Drugs Group 3 |
|
Succinylcholine
Notes |
Onset: 60sec
Duration: 3-5 min Causes Fasciculations Neuromuscular Blocking Drugs Group 3 |
|
Vecuronium
Drug (trade name) |
(Norcuron)
Neuromuscular Blocking Drugs Group 3 |
|
Vecuronium
Class |
Aminosteroid, ND
Neuromuscular Blocking Drugs Group 3 |
|
Vecuronium
Uses |
Paralysis
Neuromuscular Blocking Drugs Group 3 |
|
Vecuronium
[ Supplied ] |
10mg powder vial, reconst. to 1mg / ml w / 10cc sdH2O
Neuromuscular Blocking Drugs Group 3 |
|
Vecuronium
Dosing--card |
0.1mg / kg (0.08-0.12)
Neuromuscular Blocking Drugs Group 3 |
|
Vecuronium
Dosing--Stever |
Int same, Inf 1-2mcg / kg / min, Maint 0.01mg / kg
Neuromuscular Blocking Drugs Group 3 |
|
Vecuronium
Caution |
Renal / Hepatic Dysfunction(elim. Via these routes), Peds / Elderly (larger / smaller dose resp.)
Neuromuscular Blocking Drugs Group 3 |
|
Vecuronium
Notes |
onset 3-5 m
Duration: 20-35 min Neuromuscular Blocking Drugs Group 3 |
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Sympathomimetics
|
Uppers; ↑BP; pt's "tubes" not full b / c haven't eaten, dehydrated, etc., if you vasoconstrict you can increase volume compared to size of tube, inserting ETT raises BP b / c it is a strong stimulus, then BP may drop until next stimulus--surgical incision, so may need to use these until then to keep BP at desired / reasonable rate; Divided into Catecholamines & Synthetic Noncatecholamines; work through activation of α (vasculature--vasocontriction), β1 (heart--↑HR) and / or β2 (lungs--brachial relaxation) receptors--remember this w / mnemonic 1 Heart, 2 lungs for beta receptors
Sympathomimetics Group 7 |
|
Sympathomimetics
|
Describes a drug that stimulates the sympathetic nervous system or produces physiological effects similar to it
|
|
Ephedrine
Drug (trade name) |
Ephedrine
Sympathomimetics Vasoactive Drugs Group 7 |
|
Ephedrine
Class |
Synthetic non-catecholamine; direct / indirect action
Sympathomimetics Vasoactive Drugs Group 7 |
|
Ephedrine
Uses |
↑HR / BP
Sympathomimetics Vasoactive Drugs Group 7 |
|
Ephedrine
[ Supplied ] |
5mg / ml(from 25 or 50 mg / 1mL vial)
Sympathomimetics Vasoactive Drugs Group 7 |
|
Ephedrine
Dosing--card |
5mg (5-25) initial dose
Sympathomimetics Vasoactive Drugs Group 7 |
|
Ephedrine
Dosing--Stever |
5-20 mg
Sympathomimetics Vasoactive Drugs Group 7 |
|
Ephedrine
Caution |
Tachyphylaxis (tolerance), depletion of norepinephrine
Sympathomimetics Vasoactive Drugs Group 7 |
|
Ephedrine
Notes |
works @ symp. N terminal & releases norepinephrine to ↑BP
Sympathomimetics Vasoactive Drugs Group 7 |
|
Phenylephrine
Drug (trade name) |
Phenylephrine
Sympathomimetics Vasoactive Drugs Group 7 |
|
Phenylephrine
Class |
Synthetic non-catecholamine; direct action
Sympathomimetics Vasoactive Drugs Group 7 |
|
Phenylephrine
Uses |
↑BP, Nasal decongestant (use w / insertion of NA)
Sympathomimetics Vasoactive Drugs Group 7 |
|
Phenylephrine
[ Supplied ] |
100mcg / mL
Sympathomimetics Vasoactive Drugs Group 7 |
|
Phenylephrine
Dosing--card |
100mcg (50-200)
Sympathomimetics Vasoactive Drugs Group 7 |
|
Phenylephrine
Dosing--Stever |
Bolus 50-100mcg, Inf 0.25-1 mcg / kg / min
Sympathomimetics Vasoactive Drugs Group 7 |
|
Phenylephrine
Caution |
Increased afterload(heart pumping against high P), Reflex Bradycardia (↑BP but ↓HR)
Sympathomimetics Vasoactive Drugs Group 7 |
|
Phenylephrine
Notes |
binds to α receptors to vasoconstrict "pipe"
Sympathomimetics Vasoactive Drugs Group 7 |
|
Opioids / Narcotics
|
Pain Relief; choose based on potency, onset / duration time and method of metabolization (keep byproducts and their toxicity in mind).
Opioids / Narcotics Group 4 |
|
Opioids
|
Any opium-containing substance that is produced naturally in the brain.
Similar in effect or properties to opium but not derived from opium. An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract. The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids. The analgesic (pain relieving) effects of opioids are due to decreased perception of pain, decreased reaction to pain as well as increased pain tolerance. The side effects of opioids include sedation, respiratory depression, and constipation. Opioids can cause cough suppression, which can be both an indication for opioid administration or an unintended side effect. |
|
Narcotics
|
Agents that benumb or deaden, causing loss of feeling or paralysis.
Something that soothes, induces sleep, relieves pain or stress, or causes a sensation of mental numbness. |
|
Fentanyl
Drug (trade name) |
Fentanyl
Opioids / Narcotics Group 4 |
|
Fentanyl
Class |
synthetic opioid
Opioids / Narcotics Group 4 |
|
Synthetic Opioid
|
An Opiod made artificially by chemical synthesis, especially so as to resemble a natural product
|
|
Fentanyl
Uses |
Analgesia
Opioids / Narcotics Group 4 |
|
Fentanyl
[ Supplied ] |
50mcg / ml
Opioids / Narcotics Group 4 |
|
Fentanyl
Dosing--card |
1-2mcg / kg premed; 2-5mcg / kg during Ind.
Opioids / Narcotics Group 4 |
|
Fentanyl
Dosing--Stever |
low dose 1-2mcg / kg, mod dose 2-20 mcg / kg, Inf 1-2mcg / kg / hr
Opioids / Narcotics Group 4 |
|
Fentanyl
Caution |
75-125x more potent than morphine
Opioids / Narcotics Group 4 |
|
Fentanyl
Notes |
VERY lipid soluble & protein bound, can do IV,transdermal or PO, Peak effect 3-5m, duration 30-60m, 75% undergoes 1st pass pulmonary uptake / metab., Hemodynamic stability(doesn't cause histamine release), Drug interactions (can dec. inhalation / induction agent dose req'd), can cause postop depression
Opioids / Narcotics Group 4 |