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125 Cards in this Set

  • Front
  • Back
Routes of Admin
Enteral (via GI / alimentary Tract--Oral; Sublingual, Rectal) or Parenteral (NOT via GI tract--Inhalation; IV; IM; SC; Transdermal, Topical)

Routes of Admin
Anxiolytics / Premed / Morning Cocktail
can give w / narcotic like Fentanyl, but lower dose or will see resp depression

Anxiolytics / Premed / Morning Cocktail
Group 1
Anxiolytics
a drug that relieves anxiety.

An anxiolytic (antipanic or antianxiety agent) is a drug prescribed for the treatment of symptoms of anxiety.

Some anxiolytics have been shown to be useful in the treatment of anxiety disorders, as have antidepressants such as the class of selective serotonin reuptake inhibitors (SSRIs).
Midazolam
Drug
(trade name)
(versed)

Anxiolytics / Premed / Morning Cocktail
Group 1
Midazolam
Class
Benzodiazepine

Anxiolytics / Premed / Morning Cocktail
Group 1
Benzodiazepine
a drug belonging to a group of minor tranquilizers.

Use: short-term treatment for sleeping difficulties.

Benzodiazepines have varying sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, muscle relaxant and amnesic properties.

These properties make benzodiazepines useful in treating anxiety, insomnia, agitation, seizures, muscle spasms, and alcohol withdrawal.

Benzodiazepines vary in their elimination half-life, and are categorized as either short-, intermediate- or long-acting.

Short- and intermediate-acting benzodiazepines are preferred for the treatment of insomnia; longer-acting benzodiazepines are recommended for the treatment of anxiety.
Midazolam
Uses
Anxiolysis,
Sedation, Amnesia

Anxiolytics / Premed / Morning Cocktail
Group 1
Midazolam
[ Supplied ]
1mg / mL

Anxiolytics / Premed / Morning Cocktail
Group 1
Midazolam
Dosing--card
1mg
(0.5-2.0) or 0.15-0.3 mg / kg

Anxiolytics / Premed / Morning Cocktail
Group 1
Midazolam
Dosing--Stever
1-2.5mg

Anxiolytics / Premed / Morning Cocktail
Group 1
Midazolam
Caution
Hepatic Disease, Elderly, Synergy w / Narcotics

Anxiolytics / Premed / Morning Cocktail
Group 1
Midazolam
Notes
Onset 2-5m

Anxiolytics / Premed / Morning Cocktail
Group 1
Induction Drugs
very lipid soluble, fast on, fast off, short duration (3-5m), Note Propofol / etomidate burn on injection, ketamine has Analgesic effects, and thiopental has a high pH…watch out for crystallization of drug if added w / acidic drug…instead, push thiopental, flush through into body w / IV fluid, then do acidic drug

Induction Drugs
Group 2
Propofol
Drug
(trade name)
(Diprivan)

Induction Drugs
Group 2
Propofol
Class
Diisopropylphenol

Induction Drugs
Group 2
Propofol
Uses
Induction,
Sedation, MAC

Induction Drugs
Group 2
Propofol
[ Supplied ]
10mg / mL

Induction Drugs
Group 2
Propofol
Dosing--card
2mg / kg
(1-2.5)

Induction Drugs
Group 2
Propofol
Dosing--Stever
1.5-2.5mg / kg Ind; 25-100mcg / kg / min Inf.

Induction Drugs
Group 2
Propofol
Caution
Bacterial growth, soy / egg allergy

Induction Drugs
Group 2
Propofol
Notes
Pain on injection, emulsion, elim via redist., ↓ PONV & BP

Induction Drugs
Group 2
Sodium Thiopental
Drug
(trade name)
Sodium Thiopental
(aka: Sodium Pentothal)

Induction Drugs
Group 2
Sodium Thiopental
Class
Barbiturate

Induction Drugs
Group 2
Barbiturate
A drug with sedative and hypnotic properties belonging to a group of derivatives of barbituric acid
Sodium Thiopental
Uses
Induction,
cerebral protection

Induction Drugs
Group 2
Sodium Thiopental
[ Supplied ]
2.5%

Induction Drugs
Group 2
Sodium Thiopental
Dosing--card
4mg / kg (3-6)

Induction Drugs
Group 2
Sodium Thiopental
Dosing--Stever
3-5 mg / kg

Induction Drugs
Group 2
Sodium Thiopental
Caution
Drug Interaction (add acidic drug w / it-->Precip.); Apnea

Induction Drugs
Group 2
Sodium Thiopental
Notes
Will burn b / c high pH of 10 v. pH of blood 7.4;
Garlic Taste

Induction Drugs
Group 2
Local Anesthetics
Transient loss of sensory, motor, and autonomic function in a discrete portion of the body; reversible conduction of blockade of impulses along central and peripheral nerve pathways; Divided into Amides and Esters; Amides ( I b4 caine) metabolized by liver & Esters (no i b4 caine) metabolized in plasma via plasma cholinesterases, also will cause allergic Rxn in ppl allergic to PABA in sunscreen. Note that Vasoconstrictors (i.e. Epinephrine) increase duration of action of local anesthetic by limiting systemic absorption and maintaining the drug [c] at the nerve. It also decreases possibility of systemic toxicity and has little effect on onset (use 5mcg / ml or 1:200,000 Epi w / local anesthetic); Symptoms of Toxicity: Circumoral numbness (lips), Tinnitus (ringing in ears), taste pennies, lightheadedness, visual disturbances, muscular twitching, unconsciousness, convulsions, respiratory depression, cardiovascular collapse (described w / increasing levels of toxicity);PVC=premature ventricular contraction; Infiltration=using lidocaine to numb area b4 giving IV / creating wheal under skin; use nebulizer to numb airway for awake intubation; use at induction to attenuate burning on injection of induction drugs; IV regional anesthesia (IVRA) = Bier Block; Peripheral Nerve Block (PNB) = ankle or femural block;
.


Local Anesthetics
Group 11
Local Anesthetics
An anesthetic that causes loss of sensation only to the area to which it is applied.
A local anesthetic is a drug that causes reversible local anesthesia and a loss of nociception.
When it is used on specific nerve pathways (nerve block), effects such as analgesia (loss of pain sensation) and paralysis (loss of muscle power) can be achieved.
Lidocaine
Drug
(trade name)
Lidocaine

Local Anesthetics
Group 11
Lidocaine
Class
Amide

Local Anesthetics
Group 11
Amide
In chemistry, amide usually refers to organic compounds that contain the functional group consisting of an acyl group (C=O) linked to a nitrogen atom (N).
The term refers both to a class of compounds and a functional group within those compounds.
The term amide also refers to deprotonated form of ammonia (NH3) or an amine, often represented as anions R2N-.
Lidocaine
Uses
local anesthesia, cough, inhalation

Local Anesthetics
Group 11
Lidocaine
[ Supplied ]
0.5-5%

Local Anesthetics
Group 11
Lidocaine
Dosing--card
1mg / kg IV

Local Anesthetics
Group 11
Lidocaine
Dosing--Stever
Topical (4%); Infiltration (0.5-1%); IVRA (0.25-0.5%); PNB (1-1.5%); Epidural (1.5-2%); Spinal (1.5-5%)

Local Anesthetics
Group 11
Lidocaine
Caution
Hepatic Disease (metab. In liver)

Local Anesthetics
Group 11
Lidocaine
Notes
Hepatic Clearance
Toxic Dose: 5mg / kg alone
7 mg / kg with Epi

Local Anesthetics
Group 11
NMB Reversal Drugs
The Wake Up; Induction drugs long gone, turned gas off so that is gone too, need to get rid of NMBs; Anticholinesterase Drugs prevent the hydrolysis of Ach, and an increase [Ach] @ NMJ competes with ND NMBDs; clinical uses--reversal of Non-depol NMBDs; Mech. of action--enzyme inhibition, pre-synaptic effects, NMJ effects; get this increase [Ach] everywhere though, so get the BLUDS effect--attenuate by using in combination w / Anticholinergic drugs; BLUDS= bradycardia / bronchospasm, lacrimation, urination, defication, salivation; Anticholinergic Drugs used clinically most often as pre-op med, for treatment of bradycardia, for NDNMB reversal and less frequently for bronchodialation, smooth muscle relaxant, antagonist of gastric acid secretion, & to prevent N / V; work by blocking muscarinic Ach receptors activated by parasymp. NS, careful though....will cause dialation of pupils (worsens Glaucoma) and will cross placenta in pregnant woman (Cautions=Glaucoma / Parturients). (Parturient=pregnant woman)

NMB Reversal Drugs
Group 9
Atropine
Drug
(trade name)
Atropine

NMB Reversal Drugs
Group 9
Atropine
Class
Anticholinergic

NMB Reversal Drugs
Group 9
Anticholinergic
An _____ agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an .
is dicyclomine. .
s are administered to reduce the effects mediated by acetylcholine on acetylcholine receptors in neurons through competitive inhibition. Therefore, their effects are reversible.
Atropine
Uses
Bradycardia, accompany NMB Reversal to fight BLUDS

NMB Reversal Drugs
Group 9
Atropine
[ Supplied ]
0.4, 0.5, 1mg / ml

NMB Reversal Drugs
Group 9
Atropine
Dosing--card
1.0mg vagolytic dose; 0.01mg / kg NMB reversal

NMB Reversal Drugs
Group 9
Atropine
Dosing--Stever
IM 0.01-0.02 mg / kg (up to 0.4-0.6 mg); Bradycardia 0.4-0.6mg (up to 3mg)

NMB Reversal Drugs
Group 9
Atropine
Caution
Glaucoma, Parturients

NMB Reversal Drugs
Group 9
Atropine
Notes
||
NMB Reversal Drugs
Group 9
Neuromuscular Blocking Drugs
Paralysis / Muscle Relaxation; Facilitate tracheal intubation, improve surgical working conditions, good for mechanical ventilation of lungs, treat laryngospasm; Classified / chosen according or whether Depolarizing (mimics ACh, binds receptor @ muscle and activates receptor) or Non-depolarizing (binds @ receptor and blocks ACh), duration of action (whether long, intermediate or short acting; duration also affected by liver / kidney disease so keep that in mind), speed of onset, side effects, & pathophysiology; Act by interupting transmission of nerve impulses at NMJ of muscles; review in ppt adverse effects of SUX); Note: Int= Intubation Dose, Inf= Infusion

Neuromuscular Blocking Drugs
Group 3
Neuromuscular Blocking Drugs
Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles.

This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release, or by acting postsynaptically at the acetylcholine receptor.

While there are drugs that act presynaptically (such as botulin toxin and tetrodotoxin), the clinically-relevant drugs work postsynaptically.

Clinically, neuromuscular block is used as an adjunct to anesthesia to induce paralysis, so that surgery, especially intra-abdominal and intra-thoracic surgeries, can be carried out with fewer complications.

Because neuromuscular block may paralyze muscles required for breathing, mechanical ventilation should be available to maintain adequate respiration.

Patients are still aware of pain even after full conduction block has occurred; hence, general anesthetics and / or analgesics must be given to prevent anesthesia awareness.
Cisatracurium
Drug
(trade name)
(Nimbex)

Neuromuscular Blocking Drugs
Group 3
Cisatracurium
Class
Benzyl isoquinolinium, ND

Neuromuscular Blocking Drugs
Group 3
Benzyl isoquinolinium
Isoquinolines find many applications, including (but not limited to): anesthetics; dimethisoquin is one example.
vasodilators, a well-known example, papaverine.
Cisatracurium
Uses
Paralysis

Neuromuscular Blocking Drugs
Group 3
Cisatracurium
[ Supplied ]
20mg vial (2mg / ml)

Neuromuscular Blocking Drugs
Group 3
Cisatracurium
Dosing--card
0.1mg / kg (0.1-0.15)

Neuromuscular Blocking Drugs
Group 3
Cisatracurium
Dosing--Stever
Int same, Inf 1-2mcg / kg / min

Neuromuscular Blocking Drugs
Group 3
Cisatracurium
Caution
||
Neuromuscular Blocking Drugs
Group 3
Cisatracurium
Notes
Onset: 3-5 min
Duration: 20-35 min
Hoffman Elim.,not metab in liver / kidneys, use for pt w / renal disease

Neuromuscular Blocking Drugs
Group 3
Pancuronium
Drug
(trade name)
(Pavulon)

Neuromuscular Blocking Drugs
Group 3
Pancuronium
Class
Aminosteroid, ND

Neuromuscular Blocking Drugs
Group 3
Pancuronium
Uses
Paralysis

Neuromuscular Blocking Drugs
Group 3
Pancuronium
[ Supplied ]
1mg / mL

Neuromuscular Blocking Drugs
Group 3
Pancuronium
Dosing--card
0.1mg / kg (0.08-0.12)

Neuromuscular Blocking Drugs
Group 3
Pancuronium
Dosing--Stever
Int same, Mt 0.01mg / kg

Neuromuscular Blocking Drugs
Group 3
Pancuronium
Caution
↑ HR (tachycardia), MAP, CO; Clearance ↓ up to 50% w / renal failure

Neuromuscular Blocking Drugs
Group 3
Pancuronium
Notes
Onset: 3-5 min
Duration: 60-90 min
Long duration, Hepatic / Renal Elim.

Neuromuscular Blocking Drugs
Group 3
Rocuronium
Drug
(trade name)
(Zemuron)

Neuromuscular Blocking Drugs
Group 3
Rocuronium
Class
Aminosteroid, ND

Neuromuscular Blocking Drugs
Group 3
Aminosteroid
Aminosteroids are a group of drugs with a similar structure based on a steroid nucleus.
Examples are the muscle relaxants rocuronium, vecuronium and pancuronium.
Rocuronium
Uses
Paralysis, RSI

Neuromuscular Blocking Drugs
Group 3
Rocuronium
[ Supplied ]
10mg / ml

Neuromuscular Blocking Drugs
Group 3
Rocuronium
Dosing--card
0.6mg / kg (0.6-1.2)

Neuromuscular Blocking Drugs
Group 3
Rocuronium
Dosing--Stever
Int same (RSI dose), Maint 0.1mg / kg, Infusion 5-12 mcg / kg / min

Neuromuscular Blocking Drugs
Group 3
Rocuronium
Caution
Renal failure (b / c excreted via kidneys)

Neuromuscular Blocking Drugs
Group 3
Rocuronium
Notes
Onset: 1-2 min
Duration: 20-35min

Neuromuscular Blocking Drugs
Group 3
Succinylcholine
Drug
(trade name)
Succinylcholine (Anectine)

Neuromuscular Blocking Drugs
Group 3
Succinylcholine
Class
Depolarizing NMBD

Neuromuscular Blocking Drugs
Group 3
Succinylcholine
Uses
Intubation, Paralysis, Laryngospasm

Neuromuscular Blocking Drugs
Group 3
Succinylcholine
[ Supplied ]
20mg / ml

Neuromuscular Blocking Drugs
Group 3
Succinylcholine
Dosing--card
1mg / kg
(1-1.5)

Neuromuscular Blocking Drugs
Group 3
Succinylcholine
Dosing--Stever
Int same; Laryngospasm 0.1mg / kg IV

Neuromuscular Blocking Drugs
Group 3
Succinylcholine
Caution
Bradycardia, Hyperalkemia, open globe injury (increases cerebral, intraabdominal and intraoccular pressure)

Neuromuscular Blocking Drugs
Group 3
Succinylcholine
Notes
Onset: 60sec
Duration: 3-5 min
Causes Fasciculations

Neuromuscular Blocking Drugs
Group 3
Vecuronium
Drug
(trade name)
(Norcuron)

Neuromuscular Blocking Drugs
Group 3
Vecuronium
Class
Aminosteroid, ND

Neuromuscular Blocking Drugs
Group 3
Vecuronium
Uses
Paralysis

Neuromuscular Blocking Drugs
Group 3
Vecuronium
[ Supplied ]
10mg powder vial, reconst. to 1mg / ml w / 10cc sdH2O

Neuromuscular Blocking Drugs
Group 3
Vecuronium
Dosing--card
0.1mg / kg (0.08-0.12)

Neuromuscular Blocking Drugs
Group 3
Vecuronium
Dosing--Stever
Int same, Inf 1-2mcg / kg / min, Maint 0.01mg / kg

Neuromuscular Blocking Drugs
Group 3
Vecuronium
Caution
Renal / Hepatic Dysfunction(elim. Via these routes), Peds / Elderly (larger / smaller dose resp.)

Neuromuscular Blocking Drugs
Group 3
Vecuronium
Notes
onset 3-5 m
Duration: 20-35 min

Neuromuscular Blocking Drugs
Group 3
Sympathomimetics
Uppers; ↑BP; pt's "tubes" not full b / c haven't eaten, dehydrated, etc., if you vasoconstrict you can increase volume compared to size of tube, inserting ETT raises BP b / c it is a strong stimulus, then BP may drop until next stimulus--surgical incision, so may need to use these until then to keep BP at desired / reasonable rate; Divided into Catecholamines & Synthetic Noncatecholamines; work through activation of α (vasculature--vasocontriction), β1 (heart--↑HR) and / or β2 (lungs--brachial relaxation) receptors--remember this w / mnemonic 1 Heart, 2 lungs for beta receptors

Sympathomimetics
Group 7
Sympathomimetics
Describes a drug that stimulates the sympathetic nervous system or produces physiological effects similar to it
Ephedrine
Drug
(trade name)
Ephedrine

Sympathomimetics
Vasoactive Drugs
Group 7
Ephedrine
Class
Synthetic non-catecholamine; direct / indirect action

Sympathomimetics
Vasoactive Drugs
Group 7
Ephedrine
Uses
↑HR / BP

Sympathomimetics
Vasoactive Drugs
Group 7
Ephedrine
[ Supplied ]
5mg / ml(from 25 or 50 mg / 1mL vial)

Sympathomimetics
Vasoactive Drugs
Group 7
Ephedrine
Dosing--card
5mg (5-25) initial dose

Sympathomimetics
Vasoactive Drugs
Group 7
Ephedrine
Dosing--Stever
5-20 mg

Sympathomimetics
Vasoactive Drugs
Group 7
Ephedrine
Caution
Tachyphylaxis (tolerance), depletion of norepinephrine

Sympathomimetics
Vasoactive Drugs
Group 7
Ephedrine
Notes
works @ symp. N terminal & releases norepinephrine to ↑BP

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Drug
(trade name)
Phenylephrine

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Class
Synthetic non-catecholamine; direct action

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Uses
↑BP, Nasal decongestant (use w / insertion of NA)

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
[ Supplied ]
100mcg / mL

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Dosing--card
100mcg (50-200)

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Dosing--Stever
Bolus 50-100mcg, Inf 0.25-1 mcg / kg / min

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Caution
Increased afterload(heart pumping against high P), Reflex Bradycardia (↑BP but ↓HR)

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Notes
binds to α receptors to vasoconstrict "pipe"

Sympathomimetics
Vasoactive Drugs
Group 7
Opioids / Narcotics
Pain Relief; choose based on potency, onset / duration time and method of metabolization (keep byproducts and their toxicity in mind).

Opioids / Narcotics
Group 4
Opioids
Any opium-containing substance that is produced naturally in the brain.
Similar in effect or properties to opium but not derived from opium.
An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract.
The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids.
The analgesic (pain relieving) effects of opioids are due to decreased perception of pain, decreased reaction to pain as well as increased pain tolerance.
The side effects of opioids include sedation, respiratory depression, and constipation.
Opioids can cause cough suppression, which can be both an indication for opioid administration or an unintended side effect.
Narcotics
Agents that benumb or deaden, causing loss of feeling or paralysis.
Something that soothes, induces sleep, relieves pain or stress, or causes a sensation of mental numbness.
Fentanyl
Drug
(trade name)
Fentanyl

Opioids / Narcotics
Group 4
Fentanyl
Class
synthetic opioid

Opioids / Narcotics
Group 4
Synthetic Opioid
An Opiod made artificially by chemical synthesis, especially so as to resemble a natural product
Fentanyl
Uses
Analgesia

Opioids / Narcotics
Group 4
Fentanyl
[ Supplied ]
50mcg / ml

Opioids / Narcotics
Group 4
Fentanyl
Dosing--card
1-2mcg / kg premed; 2-5mcg / kg during Ind.

Opioids / Narcotics
Group 4
Fentanyl
Dosing--Stever
low dose 1-2mcg / kg, mod dose 2-20 mcg / kg, Inf 1-2mcg / kg / hr

Opioids / Narcotics
Group 4
Fentanyl
Caution
75-125x more potent than morphine

Opioids / Narcotics
Group 4
Fentanyl
Notes
VERY lipid soluble & protein bound, can do IV,transdermal or PO, Peak effect 3-5m, duration 30-60m, 75% undergoes 1st pass pulmonary uptake / metab., Hemodynamic stability(doesn't cause histamine release), Drug interactions (can dec. inhalation / induction agent dose req'd), can cause postop depression

Opioids / Narcotics
Group 4