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35 Cards in this Set
- Front
- Back
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4 kinds of ca drugs
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cytotoxic
hormone tx cytokines mAbs |
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5 ca which have curative chemo
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testicular/germ cell
Ewing/PNET leukemia lymphoma small cell lung |
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___ chemo is given before surgery
___ chemo is given after |
neoadjuvant
adjuvant |
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2 ca with adjuvant chemo
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breast
colon |
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2 ca with neoadjuvant chemo
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breast (advanced)
osteogenic sarcoma |
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5 kinds of cytotoxic drugs
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alkylating agents
Pt analogs antimetabolites topoisomerase inhibitors antimicrotubule agents |
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alkylating agents have ___ charge when active. their target is ___.
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positive
DNA |
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alkylating agents ___ the DNA, which prevents ___.
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crosslink
replication |
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3 alkylating agents
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CTX
ifosfamide chlorambucil |
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MTX is a ___ analog
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folic acid
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gemcitabine is a ___ analog
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deoxyctosine
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6-mercaptopurine is a ___ analog
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hypoxanthine
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2 ways 5-FU works
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inhibition of thymidylate
misincorporated into RNA |
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___ (2) drugs are non-cell-cycle specific
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alkylating agents
Pt drugs |
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___ drugs are specific to S-phase
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antimetabolites
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2 kinds of tubulin binding drugs
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vinca alkaloids
taxanes |
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3 vinca alkaloids
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vincristine
vinblastine vinorelbine |
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vinca alkaloids inhibit microtubule ___, causing ___
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polymerization
metaphase arrest |
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taxanes inhibit microtubule ___, causing ___.
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depolymerization
arrest at G2/M |
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2 topoisomerase 1 inhibitors
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irinotecan
topotecan |
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2 kinds of topoisomerase 2 inhibitors
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anthracyclines
epipodophylotoxins |
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2 anthracyclines
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doxorubicin
daunomycin |
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cisplatin is ___(2)-toxic
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oto
neuro |
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carboplatin is ___toxic. however, it is not ___toxic
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myelo
neuro |
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oxaliplatin is ___toxic but works on ___
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neuro
CRC |
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almost all cytotoxics have dosing in terms of ___. one exception is ___
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body surface area
carboplatin |
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CHOP is used for ___. it stands for ___.
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ly
CTX hydroxydaunomycin (adriamycin) oncovin (vincristine) prednisone |
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partial response to chemo is
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30% decrease in sum of longest diameters
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progressive disease is
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20% increase in sum of longest diameters
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cytotoxic drugs have high/low therapeutic index
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low
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___ is recombinant ___, which reduces neutropenia
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filgrastim
G-CSF |
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3 neurotransmitters implicated in nausea from chemo
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5-HT
DA neurokinin-1 |
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antagonists against ___ (3) are used to reduce nausea
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5HT3R
DAR NK-1 |
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___ is a 5HT3R antagonist
___ is a DAR antagonist ___ is a NK-1 antagonist |
ondansetron
metoclopramide aprepitant |
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___ is an epipodophyllotoxin. it inhibits ___ and is used in ___.
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etoposide
topoisomerase testicular ca |
