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35 Cards in this Set

  • Front
  • Back
4 kinds of ca drugs
cytotoxic
hormone tx
cytokines
mAbs
5 ca which have curative chemo
testicular/germ cell
Ewing/PNET
leukemia
lymphoma
small cell lung
___ chemo is given before surgery
___ chemo is given after
neoadjuvant
adjuvant
2 ca with adjuvant chemo
breast
colon
2 ca with neoadjuvant chemo
breast (advanced)
osteogenic sarcoma
5 kinds of cytotoxic drugs
alkylating agents
Pt analogs
antimetabolites
topoisomerase inhibitors
antimicrotubule agents
alkylating agents have ___ charge when active. their target is ___.
positive
DNA
alkylating agents ___ the DNA, which prevents ___.
crosslink
replication
3 alkylating agents
CTX
ifosfamide
chlorambucil
MTX is a ___ analog
folic acid
gemcitabine is a ___ analog
deoxyctosine
6-mercaptopurine is a ___ analog
hypoxanthine
2 ways 5-FU works
inhibition of thymidylate
misincorporated into RNA
___ (2) drugs are non-cell-cycle specific
alkylating agents
Pt drugs
___ drugs are specific to S-phase
antimetabolites
2 kinds of tubulin binding drugs
vinca alkaloids
taxanes
3 vinca alkaloids
vincristine
vinblastine
vinorelbine
vinca alkaloids inhibit microtubule ___, causing ___
polymerization
metaphase arrest
taxanes inhibit microtubule ___, causing ___.
depolymerization
arrest at G2/M
2 topoisomerase 1 inhibitors
irinotecan
topotecan
2 kinds of topoisomerase 2 inhibitors
anthracyclines
epipodophylotoxins
2 anthracyclines
doxorubicin
daunomycin
cisplatin is ___(2)-toxic
oto
neuro
carboplatin is ___toxic. however, it is not ___toxic
myelo
neuro
oxaliplatin is ___toxic but works on ___
neuro
CRC
almost all cytotoxics have dosing in terms of ___. one exception is ___
body surface area
carboplatin
CHOP is used for ___. it stands for ___.
ly
CTX
hydroxydaunomycin (adriamycin)
oncovin (vincristine)
prednisone
partial response to chemo is
30% decrease in sum of longest diameters
progressive disease is
20% increase in sum of longest diameters
cytotoxic drugs have high/low therapeutic index
low
___ is recombinant ___, which reduces neutropenia
filgrastim
G-CSF
3 neurotransmitters implicated in nausea from chemo
5-HT
DA
neurokinin-1
antagonists against ___ (3) are used to reduce nausea
5HT3R
DAR
NK-1
___ is a 5HT3R antagonist
___ is a DAR antagonist
___ is a NK-1 antagonist
ondansetron
metoclopramide
aprepitant
___ is an epipodophyllotoxin. it inhibits ___ and is used in ___.
etoposide
topoisomerase
testicular ca