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31 Cards in this Set

  • Front
  • Back
because symptoms of early chronic liver disease are ___, detection is via ___.
nonexistent
liver enzymes
AST is expressed by ___ (7)
liver
lung
leukocytes
brain
cardiac muscle
striated muscle
kidney
T/F: AST is present in cytosol
T/F: AST is present in mitochondria
true
true
AST is aka
SGOT
ALT is expressed by ___
liver
T/F: ALT is present in cytosol
T/F: ALT is present in mitochondria
true
false
patients with renal failure have low ___ activity
ALT
2 parenchymal liver enzymes
AST
ALT
2 bile duct-related liver enzymes
GGT
ALP
liver enzyme elevation is mild if ___, moderate if ___, severe if ___.
<5 x normal
5--15 x normal
> 15 x normal
in general ___ is higher than ___ in liver disease. 3 exceptions are
ALT
AST
alcohol
fatty liver
cirrhosis
4 illicit drugs which cause abnormal AST/ALT
PCP
ecstasy
anabolic steroids
cocaine
6 viruses which can cause severe ALT, AST elevation
hep A-E
HSV
ALP is expressed in ___ (6)
liver
bone
intestine
placenta
leukocytes
kidney
half life of ALP
3 days
ALP in blood is from ___ (2)
liver
bone
ALP is increased in ___ (2 populations)
pregnant women
children
in bone ALP is expressed by ___
osteoblasts
GGT is expressed in ___ (5)
liver
kidney
pancreas
heart
brain
half life of GGT
7 days
GGT is increased in ___ (5 non-hepatic diseases)
DM
hyperthyroidism
RA
chronic lung disease
MI
3 kinds of infiltrating diseases which cause elevated ALP
granulomatous disease
amyloidosis
malignancy
deficient enzyme in Gilbert's is ___, which causes deficient ___. this causes elevated ___. jaundice can be corrected with ___.
UDPGT
bilirubin conjugation
indirect bilirubin
phenobarbital
deficient enzyme in Crigler-Najjar is ___. difference from Gilbert's is ___.
UDPGT
zero enzyme expression in Crigler
___ is deficient in Dubin-Johnson and Rotor's syndromes
secretion of conjugated bilirubin into canaliculi
Crigler-Najjar type ___ is the most severe. it causes ___
1
death in infancy
PT prolongation is ___ in Child's 1, ___in Child's 2, ___ in Child's 3.
1--4
4--10
>10
serum albumin is ___ in Child's 1, ___ in Child's 2, ___ in Child's 3
>3.5 g/dL
2.8--3.5
<2.8
Child's ___ get liver transplants
3
3 parameters in MELD equation
creatinine
bilirubin
PT
5 parameters in Child's criteria
encephalopathy
ascites
serum bilirubin
serum albumin
PT