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31 Cards in this Set
- Front
- Back
because symptoms of early chronic liver disease are ___, detection is via ___.
|
nonexistent
liver enzymes |
|
AST is expressed by ___ (7)
|
liver
lung leukocytes brain cardiac muscle striated muscle kidney |
|
T/F: AST is present in cytosol
T/F: AST is present in mitochondria |
true
true |
|
AST is aka
|
SGOT
|
|
ALT is expressed by ___
|
liver
|
|
T/F: ALT is present in cytosol
T/F: ALT is present in mitochondria |
true
false |
|
patients with renal failure have low ___ activity
|
ALT
|
|
2 parenchymal liver enzymes
|
AST
ALT |
|
2 bile duct-related liver enzymes
|
GGT
ALP |
|
liver enzyme elevation is mild if ___, moderate if ___, severe if ___.
|
<5 x normal
5--15 x normal > 15 x normal |
|
in general ___ is higher than ___ in liver disease. 3 exceptions are
|
ALT
AST alcohol fatty liver cirrhosis |
|
4 illicit drugs which cause abnormal AST/ALT
|
PCP
ecstasy anabolic steroids cocaine |
|
6 viruses which can cause severe ALT, AST elevation
|
hep A-E
HSV |
|
ALP is expressed in ___ (6)
|
liver
bone intestine placenta leukocytes kidney |
|
half life of ALP
|
3 days
|
|
ALP in blood is from ___ (2)
|
liver
bone |
|
ALP is increased in ___ (2 populations)
|
pregnant women
children |
|
in bone ALP is expressed by ___
|
osteoblasts
|
|
GGT is expressed in ___ (5)
|
liver
kidney pancreas heart brain |
|
half life of GGT
|
7 days
|
|
GGT is increased in ___ (5 non-hepatic diseases)
|
DM
hyperthyroidism RA chronic lung disease MI |
|
3 kinds of infiltrating diseases which cause elevated ALP
|
granulomatous disease
amyloidosis malignancy |
|
deficient enzyme in Gilbert's is ___, which causes deficient ___. this causes elevated ___. jaundice can be corrected with ___.
|
UDPGT
bilirubin conjugation indirect bilirubin phenobarbital |
|
deficient enzyme in Crigler-Najjar is ___. difference from Gilbert's is ___.
|
UDPGT
zero enzyme expression in Crigler |
|
___ is deficient in Dubin-Johnson and Rotor's syndromes
|
secretion of conjugated bilirubin into canaliculi
|
|
Crigler-Najjar type ___ is the most severe. it causes ___
|
1
death in infancy |
|
PT prolongation is ___ in Child's 1, ___in Child's 2, ___ in Child's 3.
|
1--4
4--10 >10 |
|
serum albumin is ___ in Child's 1, ___ in Child's 2, ___ in Child's 3
|
>3.5 g/dL
2.8--3.5 <2.8 |
|
Child's ___ get liver transplants
|
3
|
|
3 parameters in MELD equation
|
creatinine
bilirubin PT |
|
5 parameters in Child's criteria
|
encephalopathy
ascites serum bilirubin serum albumin PT |