Icm Endo 06: Globerman Cushing's Syndrome

Front 1

3 causes of cushing's from most to least common

Back 1

iatrogenic
ectopic ACTH
adrenal cortisol-secreting adenoma

Front 2

4 signs of cushings present up to and exceeding 90% of cases

Back 2

centripetal obesity
facial plethora
glucose intolerance
weakness

Front 3

cushing's can cause ____ accumulation which can cause ____ resembling ____ disease

Back 3

retrobulbar fat accumulation
exopthalmos
Graves'

Front 4

impotence in Cushing's may be due to ___, which cause ____.

Back 4

elevated androgens
elevated estrogens

Front 5

in cushing's elevated cortisol causes increased susceptibility to ___

Back 5

tinea versicolor

Front 6

first test in cushing's diagnosis is ___, obtained via ___

Back 6

cortisol, 17OH corticosteroid level
24h urine collection

Front 7

2nd test in cushing's diagnosis is ___

Back 7

dexamethasone suppression test

Front 8

dex suppression test day 1

Back 8

cortisol level (before dex)
administer dex

Front 9

dex suppression test day 2

Back 9

urine collection

Front 10

dex suppression test day 3

Back 10

blood cortisol level

Front 11

in Cushing's disease, suppression is present/absent.
in ectopic ACTH, suppression is present/absent.
in adrenal adenoma, suppression is present/absent

Back 11

present
absent
absent

Front 12

Nelson's syndrome is ___

Back 12

rapid enlargement of pituitary adenoma after bilateral adrenectomy

Front 13

Cushing's disease is first treated with ___. This has a ___% cure rate. The remaining patients receive ___. This cures an additional ___% of the remainder.

Back 13

transsphenoidal surgery
80
pituitary irradiation
40

Front 14

Those not cured by surgery and irradiation receive ____ or ____. This cures ___% of the remainder. Those not cured receive ____ and then ___.

Back 14

mitotane
ketoconazole
80
adrenal enzyme inhibitors
bilateral adrenectomy

Front 15

gynecomastia typically only occurs in ___

Back 15

adrenal cancer

Front 16

in ectopic ACTH, ___ is first treatment and cures ___% of patients. in these cases the tumor is ___.

Back 16

surgical resection
<10
benign

Front 17

in ectopic ACTH, if tumor is malignant, treatment proceeds to ___ and then ___.

Back 17

adrenal enzyme inhibitors
medical or surgical adrenalectomy

Front 18

in adrenal tumors, ___ is first treatment. those not cured receive ___. those not cured by that receive ___.

Back 18

surgical resection
immediate lifelong mitotane
adrenal enzyme inhibitors

Front 19

dexamethasone has ___ anti-inflammatory action, ___ HTh-Pituitary axis suppression, and ___ salt retention action.

Back 19

high
high
no