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32 Cards in this Set
- Front
- Back
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What is IBS?
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motility disorder
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What sx are seen in IBS?
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constipation, cramping, diarrhea
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What are some treatments of IBS?
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tegaserod
alosetron fiber sx-directed anti-depressants anti-cholinergics |
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What are the 2 disease in IBD?
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ulcerative colitis
Chrons |
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What is ulcerative colitis?
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mucosal ulcers & infiltration
neutrophils, MP, lymphocytes |
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What is chrons?
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inflammation extends transmucosally
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Where do you see chron's disease?
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terminal illeum
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What are some symptoms of IBD?
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secretory diarrhea, constpiation, bleeding & episodes of incontinence
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What are some complications of IBD?
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intestinal perforation, toxic megacolon, cancer
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What are the drus used to treat IBD?
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prednisone
olsalazine mesalamine sulfasalazine infliximab |
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What is prednisone used to treat?
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acute attacks
moderate to severe |
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How does prednisone work?
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inhibits inflammation by suppressing the immune sys
inhibits PG & leukotriene synthesis decreased capillary perm |
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What are the disadvantages of using prednisone to treat IBD?
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adrenal pituitary suppression
immunosuppression bleeding ulcers hypertentions osteoperosis |
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IBD can be treated with antimetabolites, what are some we talked about earlier?
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mercaptopurine
azathioprine |
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What do anti-metabolites do?
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inhibit purine synthesis therefore DNA synth
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What are the SE of anti-metabolites?
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BM suppression, vomiting, jaundice, pancreatitis
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What are the 5-aminosalicylates?
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olsalazine
mesalamine sulfasalazine |
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What do the 5-aminosalicylates treat?
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ulcerative colitis
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What is the mechanism of action?
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inhibition of IL-1 & TNF-a production & lipoxy genase
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Which are prodrugs?
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sulfasalazine
olsalazine |
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Which is metabolized in the liver?
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sulfasalazine
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Which is metabolized by colonic bacteria?
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olsalazine
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What are sulfasalazine & olsalazine metabolized to?
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mesalamine
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For which drug are there more SE?
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sulfasalazine
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What are the SE?
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fever, malaise, vomiting, headache, decreased sperm #
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Which drug is contraindcated in pts with liver or renal disease?
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sulfasalazine
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What is the contraindication for all of these drugs?
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allergy to salicylates
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What are these drugs used to treat?
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ulcerative colitis
prophylactically not acute |
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What is infliximab?
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monoclonal Ab to TNFa
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What is infliximab used to treat?
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crohns
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What is the result of treatment with infliximab?
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cell lysis
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What are the SE of infliximab?
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increased upper respiratory infections, delayed hypersensitivity, lupus like symptoms, fever
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