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25 Cards in this Set
- Front
- Back
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bilateral lesion in VMH?
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incr PS decr Symp, OBESE
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bilateral lesion in VLH?
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anorexia, incr symp, decr PS
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unilateral VMH lesion
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animals eat excessively until they reach some new higher body weight set pt and then maintain it
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unilateral lesion of VLH
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animals stop eating until they reach a new set point
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where is the site of integration for humoral signals of satiety?
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arcuate nucleus
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what are the neural inputs to the PVN
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solitary nucleus, area postrema, raphe nuclei
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what happens if you have a lesion in area postrema?
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large meals
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what are the tracts assoc with satiety pathways?
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medial forebrain bundle (to PVN and LHA)
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where does the arcutae nucelus project to?
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LHA, VM, PVN and DM
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where does the PVN project to?
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arcuate nucleus, VMH, LHA
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why is the DM imp for?
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integration of limbic input to feeding and satiety and provide the link between the VMH and LHA
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where is the body weight set point
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arcuate nucleus
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what is the pvn imp for in regards to eating?
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pvn is final integration of autonomic tone resulting in either feeding or satiety
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what are the anabolic/orexigenic peptides?
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NPY, AGRP, MCH, Orexin, Galanin
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how does AGRP work?
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antagonist for anoreixgenic peptides (blocks MC3 and 4 receptors)
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what are the catabolic peptides?
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alpha MSH, gamma MSH, CART, GLP1 and 2, PrlRP,
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what receptor does alpha MSH bind to?
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MC4; alpha MSH is the big anorexigenic signal
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what receptor does gamma MSH bind to?
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MC3
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what can high levels of leptin lead to?
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insulin resistance
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what is pickwickian syndrome?
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hypertension and hypoventilation
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froelich's syndrome
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hypogonadotropic hypogonadism, diabetes, insipidis -- all possibly due to hypothalamic lesion
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what are the humoral signals of satiety?
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insulin, leptin, glucose, CCK, PP and PPY
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what are the humoral signals of hunger?
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ghrelin
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what are glucose responsive neurons?
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incr firing rate with glucose levels
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what are glucose sensitive neurons
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stimulated as glucose levels fall
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