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7 Cards in this Set
- Front
- Back
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What does the hypothalamus release? How about the pituitary gland? How about the adrenal glands? What is dexamethasone?
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CRF
ACTH glucocorticoids (cortisol) mineralocorticoids and catecholamines Dexmethasone is a synthetic cortisol/mineralicorticoid |
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Glucorticoid receptors? upon binding, what happens?
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upon binding, they lose HSP and get GR-GR dimerization
Type 1- high affinity for mineralicorticoids; maintain basal tone |
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What are the functions of cortisol in the stress response?
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Increased gluconeogenesis, also get conversion of food glycogen/fat and conversion fo protein into fat..BUILD UP Energy reserve
Inhibits immune response and it inhibits osteoblasts, leading to decreased bone mass |
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Normally, the stess response is adaptive. What happens if we have chronically high cortisol levels?
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Get sleep disturbances, attentional disruption, memory loss, CV disease, susceptibility to infection, osteoporosis
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When does cortisol peak as part of its diurnal rythm? Where does cortisol act to do (-) feedback?
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In the morning, to get us going for the day.
Acts on pituitary gland, hypothalamus, and hippocampus. |
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CRF; are there many receptors in the brain? What about CRF's role in the stress response?
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widely distributed
It is crucial to the stress reponse as it causes increased sympathetic activity |
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What disease is implicated with a dysregulation of the HPA system? What is lost and what symptoms remian? Can a loving mothering style lead to epigenetic modification of the R receptor?
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Depression; loss circadian rythms and get hyperactive HPA, leading to insomnia, loss of libido,appetite and hyperarousal
YES. Makes individuals less responsive to stress and less anxious |
