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20 Cards in this Set

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Autoimmune hemolytic anemia
Type 2 against Rh antigens, I antigen on RBCs leads to Opsonization and phagocytosis of erythrocytes causing Hemolysis and Anemia
Hemolytic disease of the newborn
Type 2 against Antigens on erythrocytes leads to RBC degradation causing Reticulocytosis and Anemia
Autoimmune thrombocytopenic purpura
Type 2 against Glycoprotein IIb/IIIa on platelets leads to Opsonization and phagocytosis of platelets causing Bleeding diathesis
Pemphigus vulgaris
Type 2 against Epidermal cadherins leads to Activation of proteases and Disruption of cell adhesion molecules causing Bullae
ANCA-associated vasculitides
Type 2 against Neutrophil granule proteins leads to Neutrophil degranulation and inflammation causing Vasculitis
Goodpasture's syndrome
Type 2 against Noncollagenous protein leads to Complement and Fc-receptor-mediated inflammation causing Nephritis and Lung hemorrhage
Acute rheumatic fever
Type 2 against M proteins on Group A streptococci and then myocardial antigen leads to Macrophage activation and Inflammation causing Myocarditis and Arthritis
Myasthenia gravis
Type 2 against Acetylcholine receptor leads to Competitive acetylcholine inhibition and Receptor down-regulation causing Muscle weakness and Paralysis
Graves disease
Type 2 against TSH receptor leads to Receptor agonism causing Hyperthyroidism
Pernicious anemia (if autoimmune)
Type 2 against Intrinsic factor on gastric parietal cells leading to Decreased vitamin B12 absorption causing Abnormal erythropoiesis and Anemia
Type 1
IgE mediated - often called Allergy or immediate seen in reactions such as: Atopy, Anaphylaxis, and Asthma
Type 2
IgM or IgG and Complement mediated - often called Cytotoxic or antibody-dependent seen in reactions such as: Autoimmune hemolytic anemia, Hemolytic disease of the newborn, Autoimmune thrombocytopenic purpura, Pemphigus vulgaris, ANCA-associated vasculitides, Goodpasture's syndrome, Acute rheumatic fever, Myasthenia gravis, Graves disease, and Pernicious anemia (if autoimmune)
Type 3
IgG and Complement mediated - oftern called Immune complex disease seen in reactions such as: Systemic lupus erythematosus, Post-streptococcal glomerulonephritis, Polyarteritis nodosa, Reactive arthritis, Serum sickness, and Arthus reaction
Type 4
T-cell medciated often called Delayed-type hypersensitivity, Cell-mediated immune memory response or antibody-independent seen in reactions such as: Contact dermatitis, Tuberculin skin test, Chronic transplant rejection, and Multiple sclerosis
Systemic lupus erythematosus
Type 3 against Nuclear antigens leads to Nephritis, Skin lesions, and Arthritis
Post-streptococcal glomerulonephritis
Type 3 against Streptococcal cell wall antigens leads to Nephritis
Polyarteritis nodosa
Type 3 against Hepatitis B virus antigen leads to Systemic vasculitis
Reactive arthritis
Type 3 against Several bacterial antigens leads to Acute arthritis
Serum sickness
Type 3 against Various target antigens leads to Arthritis, Vasculitis, Nephritis
Arthus reaction
Type 3 against Various target antigens leads to Cutaneous vasculitis