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14 Cards in this Set
- Front
- Back
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Name the four types of hypersensitivity reactions.
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IgE dependent mast cell activation
Antibody-dependent reaction Deposition of antibody complexes Antibody-independent T-cell mediated reactions |
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Give examples of Type I hypersensitivity
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Atopic disorders
Drug hypersensitivity |
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Give examples of Type II hypersensitivity
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Lysis - Transfusion reactions, cold hemolytic anaemia, Goodpastures, Pernicious anaemia
Phagocytosis - Autoimmune hemolytic anaemia, ABO, Rh disease, ITP Antibody dependent cell-mediated cytotoxicity - helminths, NK cells Surface receptors - Graves, Myasthenia gravis |
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Give examples of Type III hypersensitivity
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SLE
Serum sickness Post-streptococcal glomerulonephritis |
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Give examples of Type IV hypersensitivity
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PPD, MS, Tuberculous granuloma
Contact dermatitis |
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What are the two types of antibody-dependent reactions in type II hypersensitivity?
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Complement dependent
Complement independent |
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Give examples of complement independent reactions
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Cell-mediated cytotoxicity
Antibodies against receptors |
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Give examples of complement dependent reactions
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IgG mediated lysis - chemotactic activation of neuts via complement - C5a
IgM mediated lysis - antibody activates complement directly Phagocytosis - C3b |
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What tests are used to evaluate Type II hypersensitivity?
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Direct Coombs test
Indirect Coombs test |
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What test is used to evaluate Type III hypersensitivity?
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Immunoflourescent staining
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What test is used to evaluate Type IV hypersensitivity?
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Patch testing
Quantitative T cell counts Mitogenic assays |
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What types of Type IV hypersensitivity exist?
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Delayed reaction hypersensitivity - CD4 mediated cytokine injury
Cell-mediated cytotoxicity - MHC I molecules with CD 8 |
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What type of reaction is Granulomatous TB? How does it occur?
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DRH
Cytokine mediated injury |
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What type of reaction is contact dermatitis?
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DRH and cell-mediated hypersensitivity
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