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14 Cards in this Set
- Front
- Back
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What type of Ig, cells, mediators and cytokines are involved in Type I hypersensitivity?
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Run by IgE: IMMEDIATE
Mast and Eosinophils Mediators: vasoactive-histamine, prostaglandins and leukotrienes TNF & IL-5 |
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What types of antibodies, receptors recruiting what cells are involved in TYPE II Hypersensitivity?
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ANTIBODY MEDIATED: IgM & IgG
Complement and Fc receptor recruite and acivate Neutrophils and Macrophages |
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What type of disease is Type III hypersensitivity associated with and what mediators bring in what cells?
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Immunocomplex mediated disorder NOT cellular (microbe); Ex: lupus
Mediated by coplement and Fc receptor bring in Leukocytes which cause the tissue damage |
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What type of Hypersensitivity is Type IV and what cells is it mediated by?
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CELL MEDIATD IMMUNE DISORDER; DTH
Cell mediated by both type of T cells ar the cause of the cellular and tissue injury |
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What are causes of Type I hypersensitivity?
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Inhaled materials: Pollen, dander, spores, dust
Injected material: insect venom (bee), vaccines, drugs Ingested material: Drugs, food-peanuts, shellfish Contacted materials: plant leaves (poison ivy), metals, latex; can be either Type I or IV depending on time(15 mins, 48 hours) |
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What type of reactions in Type I can cause anaphylaxis?
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Injected material, ingested material, RARELY inhaled material
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What are 2 diseases associated with Type II hypersensitivity?
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Goodpasstures Syndrome and Acute Rhematic Fever
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What is the Mechanism of Disesae for Good Pastures and what is target anigen and what is the clinic manifestations?
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Complement and Fc receptor mediated inflammation
Noncollagenous protein in basement membrane of kidney and lung alveoli Neutrophils, lung hemorrhages |
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What is the Mechanism of disesae in Acute Rheumatic Fever and what is the Target Antigen and what is the clinic manifestation?
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Inflammation, macrophage activation
Streptococcal cell wall antigen; antibody crossreacts with myocardia antigen Myocarditis arthristis |
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What type of Hyptersensitivity is involved with Poststreptococcal Glomerulonephritis and Lupos (SLE)?
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Hypersensitivity III
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What antigen is involved and what are the manifestations of Poststreptococcal Glomerulonephritis?
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Streptococcal Cell wall antigens; may be "planted" in glomerular basement membrane
This activated the complement cascade via C5a; various cytokines intiatied inflammation Nephritis |
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What are the clinical manifestations of lupus?
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Nephritis, arthritis and vasculitis
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What type of hypersensitivity is Lupus, what happens to the Ab involved and how do they appear histologically?
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Immune Complex Mediated Type III
Ab gets STUCK in basement membrane, DEPOSITED UNEVENLY IN CLUMPS; gieves a "lumpy bumpy" apperance NOT smooth |
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What type of hypersensitivity is Goodpastures Disease, what happens to the Ab involved and how do they appear histologically?
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Antibody Mediated; Type II
Binds SPECIFICALL to KIDNEY Ig distributed UNIFORMLY B/C ANTIGEN deposited SPECIFICALLY; Gives SMOOTH appearance |
