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14 Cards in this Set

  • Front
  • Back
What type of Ig, cells, mediators and cytokines are involved in Type I hypersensitivity?
Mast and Eosinophils
Mediators: vasoactive-histamine, prostaglandins and leukotrienes
TNF & IL-5
What types of antibodies, receptors recruiting what cells are involved in TYPE II Hypersensitivity?
Complement and Fc receptor recruite and acivate Neutrophils and Macrophages
What type of disease is Type III hypersensitivity associated with and what mediators bring in what cells?
Immunocomplex mediated disorder NOT cellular (microbe); Ex: lupus
Mediated by coplement and Fc receptor bring in Leukocytes which cause the tissue damage
What type of Hypersensitivity is Type IV and what cells is it mediated by?
Cell mediated by both type of T cells ar the cause of the cellular and tissue injury
What are causes of Type I hypersensitivity?
Inhaled materials: Pollen, dander, spores, dust
Injected material: insect venom (bee), vaccines, drugs
Ingested material: Drugs, food-peanuts, shellfish
Contacted materials: plant leaves (poison ivy), metals, latex; can be either Type I or IV depending on time(15 mins, 48 hours)
What type of reactions in Type I can cause anaphylaxis?
Injected material, ingested material, RARELY inhaled material
What are 2 diseases associated with Type II hypersensitivity?
Goodpasstures Syndrome and Acute Rhematic Fever
What is the Mechanism of Disesae for Good Pastures and what is target anigen and what is the clinic manifestations?
Complement and Fc receptor mediated inflammation
Noncollagenous protein in basement membrane of kidney and lung alveoli
Neutrophils, lung hemorrhages
What is the Mechanism of disesae in Acute Rheumatic Fever and what is the Target Antigen and what is the clinic manifestation?
Inflammation, macrophage activation
Streptococcal cell wall antigen; antibody crossreacts with myocardia antigen
Myocarditis arthristis
What type of Hyptersensitivity is involved with Poststreptococcal Glomerulonephritis and Lupos (SLE)?
Hypersensitivity III
What antigen is involved and what are the manifestations of Poststreptococcal Glomerulonephritis?
Streptococcal Cell wall antigens; may be "planted" in glomerular basement membrane
This activated the complement cascade via C5a; various cytokines intiatied inflammation
What are the clinical manifestations of lupus?
Nephritis, arthritis and vasculitis
What type of hypersensitivity is Lupus, what happens to the Ab involved and how do they appear histologically?
Immune Complex Mediated Type III
Ab gets STUCK in basement membrane, DEPOSITED UNEVENLY IN CLUMPS; gieves a "lumpy bumpy" apperance NOT smooth
What type of hypersensitivity is Goodpastures Disease, what happens to the Ab involved and how do they appear histologically?
Antibody Mediated; Type II
Ig distributed UNIFORMLY B/C ANTIGEN deposited SPECIFICALLY; Gives SMOOTH appearance