• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/21

Click to flip

21 Cards in this Set

  • Front
  • Back
MOA - lovastatin
inhibits HMG CoA reductase in liver
up regulates LDL receptor on liver
MOA - cholestyramine
blocks recycling of bile salts
increases livers need for cholesterol
up regulates LDL receptor
MOA - ezetimibe
inhibits cholesterol absorption from intestine
liver needs cholesterol from another source than diet
up regulates LDL receptor
MOA - niacin
Decreases VLDL synthesis (main)
Increases VLDL catabolism
MOA - fenofibrate
Increases VLDL catabolism (main)
Effect of simvastatin on LDL and TG (small, moderate, large increase or decrease)
large decrease LDL
moderate decrease TG
Effect of cholestyramine on LDL and TG (small, moderate, large increase or decrease)
moderate decrease LDL
transient increase TG
Effect of ezetimibe on LDL and TG (small, moderate, large increase or decrease)
moderate decrease LDL
small decrease TG
Effect of niacin on LDL and TG (small, moderate, large increase or decrease)
moderate decrease LDL
large decrease TG
Effect of gemfibrozil on LDL and TG (small, moderate, large increase or decrease)
small decrease or increase LDL
large decrease TG
which drug has the highest effect on raising HDL?
niacin
Side effect - myopathy and rhabdomyolysis
statins
Side effect - flushing
niacin
Side effect - hepatotoxicty and hyperuricemia?
niacin
Side effect - hepatotoxity
statins and niacin
Side effect - Constipation, nausea, heartburn, bloating, abdominal pain, impaired absorption of anionic drugs
and fat soluble vitamins
bile acid binding resins
Which of the following combinations will increase your risk of myopathy
Statin + cholestyramine
Statin + ezetimibe
Statin + gemfibrozil
Statin + gemfibrozil
What effect will statins and cholestyramine have on HMG CoA reductase?
statin - block activity
cholestyramine - up regulate activity
Which class of drugs will cause the greatest lowering of LDL?
statins
Which class of drugs will cause the greatest lowering of TG?
niacin and gemfibrozil
Which will lower TG better?
gemfibrozil or cholestyramine
gemfibrozil