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5 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Cholesterol synthesis inhibitors
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Statins - Simvastatin, Pravastatin, Fluvastatin, Atorvastatin, Rosuvastatin
HMG CoA reductase (-) Decr LDL, TG Incr HDL |
GIT
HA Insomnia Rash Liver problems Myalgia Myopathy Myositis Rhabdomyolysis Renal failure |
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Inhibitors of bile acid absorption / Resins
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Cholestyramine
Binds covalently to bile and (-) absorption Decr LDL No HDL benefits |
GIT - Bloating, constipation
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Fibrates
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Benzofibrates
Gemfibrozil Peroxisome proliferator activated receptor alpha / PPAR alpha, Incr beta-oxidation of fat and LPL activity Decr LDL, TG Incr HDL |
GIT discomfort
Myalgia / myositis like syndrome Arrhythmia Gallstone formation risk |
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(-) of HSL
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Niacin
Acipimox (-) HSL Decr VLDL, LDL, TG Incr HDL |
Hyperglycaemia
Hepatotoxicity Cutaneous flushing Vasodilation GIT upset Hyperuricaemia Gout |
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(-) Cholesterol absorption / Cholesterol blockers
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Ezetimbe
Phytosterols Decr GIT absorption of cholesterol |
HA
Abdominal pain Diarrhoea |
